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European Archives of Psychiatry and Clinical Neuroscience

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01-10-2019 | Original Paper

Combined cognitive, psychomotor and electrophysiological biomarkers in major depressive disorder

Authors: Ping Chai Koo, Christoph Berger, Golo Kronenberg, Julia Bartz, Peter Wybitul, Olaf Reis, Jacqueline Hoeppner

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 7/2019

Abstract

The diagnosis of major depressive disorder (MDD) should be based on multimodal evidence, because MDD not only affects mood, but also psychomotor and cognitive functions. Clinical markers such as executive dysfunctions and a reduction in daily motor activity have been observed in MDD. Neurophysiological biomarkers have also been described. In this study, we investigate the utility of combining biomarkers related to executive dysfunctions, motor activity, neurophysiological patterns (i.e. alpha power asymmetry and EEG-vigilance as indicators of brain arousal), and the interaction of these parameters in the diagnosis of MDD. Twenty (female: 11) patients with MDD (age: 51.05 ± 10.50) and 20 (female: 13) healthy controls (HC; age: 47.15 ± 12.57) underwent a 10-min resting EEG. Executive dysfunctions were assessed using the Trail Making Test B (TMT B). Motor activity was analysed by actigraphy measurements. MDD patients displayed significant impairments in executive functions and reduced daily motor activity. In the EEG, MDD patients showed more right than left frontal activity and lower brain arousal relative to HC. TMT B and asymmetrical frontal alpha power alone discriminated between MDD patients and HC with an accuracy of 78%. The interaction of motor activity and the EEG-vigilance stage alongside TMT B increased the accuracy of the discrimination test to 81%. This improved accuracy suggests that the combination of these biomarkers in a discriminant analysis resulted in a more reliable identification of MDD patients.

Only one variable was selected for logistic regression if inter-correlation occurred amongst variables; e.g. correlation between Stroop interference and TMT B, r = .629, p = 0.004, TMT B was selected as it has higher significant value from the Mann–Whitney U test.

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Title: Combined cognitive, psychomotor and electrophysiological biomarkers in major depressive disorder
Authors: Ping Chai Koo
Christoph Berger
Golo Kronenberg
Julia Bartz
Peter Wybitul
Olaf Reis
Jacqueline Hoeppner
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 7/2019
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-018-0952-9

At a glance: The STEP trials

Springer Medicine

Combined cognitive, psychomotor and electrophysiological biomarkers in major depressive disorder

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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