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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 6/2020

01-06-2020 | Colorectal Cancer | Review

Social determinants of colorectal cancer risk, stage, and survival: a systematic review

Author: Steven S. Coughlin

Published in: International Journal of Colorectal Disease | Issue 6/2020

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Abstract

Background

Several social determinants of health have been examined in relation to colorectal cancer incidence, stage at diagnosis, and survival including income, education, neighborhood disadvantage, immigration status, social support, and social network. Colorectal cancer incidence rates are positively associated with income and other measures of socioeconomic status. In contrast, low socioeconomic status tends to be associated with poorer survival.

Methods

The present review is based upon bibliographic searches in PubMed and CINAHL and relevant search terms. Articles published in English from 1970 through April 1, 2019 were identified using the following MeSH search terms and Boolean algebra commands: colorectal cancer AND (incidence OR stage OR mortality) AND (social determinants OR neighborhood disadvantage OR racial discrimination OR immigration OR social support).

Results

This review indicates that poverty, lack of education, immigration status, lack of social support, and social isolation play important roles in colorectal cancer stage at diagnosis and survival.

Conclusions

To address social determinants of colorectal cancer, effective interventions are needed that account for the social contexts in which patients live.
Literature
1.
Van Loon AJM, van den Brandt PA, Grolbohm RA (1995) Socioeconomic status and colon cancer incidence: a prospective study. Br J Cancer 71:882–887PubMedPubMedCentral
2.
Haas JS, Earle CC, Orav JE, Brawarsky P, Neville BA, Williams DR (2008) Racial segregation and disparities in cancer stage for seniors. J Gen Intern Med 23:699–705PubMedPubMedCentral
3.
Schwartz KL, Crossley-May H, Vigneau FD, Brown K, Banerjee M (2003) Race, socioeconomic status and stage at diagnosis for five common malignancies. Cancer Causes Control 14:761–766PubMed
4.
Hines R, Markossian T, Johnson A et al (2014) Geographic residency status and census tract socioeconomic status as determinants of colorectal cancer outcomes. Am J Public Health:104e63–104e71
5.
McDonald JT, Farnworth M, Liu Z (2017) Cancer and the healthy immigrant effect: a statistical analysis of cancer diagnosis using a linked census-cancer registry administrative database. BMC Public Health 17:296PubMedPubMedCentral
6.
Du XL, Fang S, Vernon SW et al (2007) Racial disparities and socioeconomic status in association with survival in a large population-based cohort of elderly patients with colon cancer. Cancer 110:660–669PubMed
7.
Egeberg R, Halkjoer J, Rottmann N et al (2008) Social inequality and incidence of and survival from cancers of the colon and rectum in a population-based study in Denmark, 1994-2003. Eur J Cancer 44:1978–1988PubMed
8.
Byers TE, Wolf HJ, Bauer KR, Bolick-Aldrich S, Chen VW, Finch JL, Fulton JP, Schymura MJ, Shen T, van Heest S, Yin X, Patterns of Care Study Group (2008) The impact of socioeconomic status on survival after cancer in the United States. Findings from the National Program of Cancer Registries Patterns of Care Study. Cancer 113:582–591PubMed
9.
Shaw C, Blakely T, Sarfati D et al (2005) Trends in colorectal cancer mortality by ethnicity and socio-economic position in New Zealand, 1981-99: one country, many stories. Aust N Z J Public Health 30:64–70
10.
Kelsall HL, Baglietto L, Muller D et al (2009) The effect of socioeconomic status on survival from colorectal cancer in the Melbourne Collaborative Cohort Study. Soc Sci Med 68:290–297PubMed
11.
Niu X, Pawlish RLM (2010) Cancer survival disparities by race/ethnicity and socioeconomic status in New Jersey. J Health Care Poor Underserved 21:144–160PubMed
12.
Kim D, Masyn KE, Kawachi I, Laden F, Colditz GA (2010) Neighborhood socioeconomic status and behavioral pathways to risks of colon and rectal cancer in women. Cancer 116:4187–4196PubMedPubMedCentral
13.
Doubeni CA, Major JM, Laiyemo A, Schootman M, Zauber AG, Hollenbeck AR, Sinha R, Allison J (2012) Contribution of behavioral risk factors and obesity to socioeconomic differences in colorectal cancer incidence. J Natl Cancer Inst 104:1353–1362PubMedPubMedCentral
14.
Doubeni CA, Laiyemo AO, Major JM, Schootman M, Lian M, Park Y, Graubard BI, Hollenbeck AR, Sinha R (2012) Socioeconomic status and the risk of colorectal cancer. Cancer 118:3636–3644PubMedPubMedCentral
15.
Steinbrecher A, Fish K, Clarke CA et al (2012) Examining the association between socioeconomic status and invasive colorectal cancer incidence and mortality in California. Cancer Epidemiol Biomark Prev 21:1814–1822
16.
Saldana-Ruiz N, Clouston SAP, Rubin MS, Colen CG, Link BG (2013) Fundamental causes of colorectal cancer mortality in the United States: understanding the importance of socioeconomic status in creating inequality in mortality. Am J Public Health 103:99–104PubMedPubMedCentral
17.
Enewold L, Horner M-J, Shriver CD, Zhu K (2014) Socioeconomic disparities in colorectal cancer mortality in the United States, 1990-2007. J Community Health 39:760–766PubMed
18.
Tannenbaum SL, Hernandez M, Zheng DD et al (2014) Individual- and neighborhood-level predictors of mortality in Florida colorectal cancer patients. PLoS One 9:e106322PubMedPubMedCentral
19.
Hastert TA, Beresford SAA, Sheppard L, White E (2015) Disparities in cancer incidence and mortality by area-level socioeconomic status: a multilevel analysis. J Epidemiol Community Health 69:168–176PubMed
20.
Gorey KM, Kanjeekal SM, Wright FC et al (2015) Colon cancer care and survival: income and insurance are more predictive in the USA, community primary care physician supply more so in Canada. Int J Equity Health 14:109PubMedPubMedCentral
21.
Beckmann KR, Bennett A, Young GP et al (2016) Socioeconomic disparities in survival from colorectal cancer in south Australia: a population-wide data linkage study. BMC Health Serv Res 16:24PubMedPubMedCentral
22.
Ellis L, Canchola AJ, Spiegel D, Ladabaum U, Haile R, Gomez SL (2018) Racial and ethnic disparities in cancer survival: the contribution of tumor, socioeconomic, institutional, and neighborhood characteristics. J Clin Oncol 36:25–33PubMed
23.
Nicolau B, Madathil SA, Castonguay G et al (2018) Shared social mechanisms underlying the risk of nine cancers: a life course study. Int J Cancer 144:59–67PubMed
24.
Gomez SL, O’Malley CD, Stroup A et al (2007) Longitudinal, population-based study of racial/ethnic differences in colorectal cancer survival: impact of neighborhood socioeconomic status, treatment and comorbidity. BMC Cancer 7:193PubMedPubMedCentral
25.
Frederiksen BL, Osler M, Harling H (2008) Social inequalities in stage at diagnosis of rectal but not in colonic cancer: a nationwide study. Br J Cancer 98:668–673PubMedPubMedCentral
26.
Greenlee RT, Howe HL (2009) County-level poverty and distant stage caner in the United States. Cancer Causes Control 20:989–1000PubMed
27.
Zhou Y, Bemanian A, Beyer KMM (2017) Housing discrimination, residential racial segregation, and colorectal cancer survival in southeastern Wisconsin. Cancer Epidemiol Biomark Prev 26:561–568
28.
Hagedoom P, Vandenheede H, Vanthomme K et al (2017) Socioeconomic position, population density and site-specific cancer mortality: a multilevel analysis of Belgian adults, 2001-2011. Int J Cancer 142:23–35
29.
Mobley LR, Scott L, Rutherford Y et al (2017) Using residential segregation to predict colorectal cancer stage at diagnosis: two different approaches. Ann Epidemiol:2710–2719
30.
Danos DM, Ferguson TF, Simonsen NR et al (2018) Neighborhood disadvantage and racial disparities in colorectal cancer incidence: a population-based study in Louisiana. Ann Epidemiol 28:316–321PubMedPubMedCentral
31.
Newman AM, Spengler RF (1984) Cancer mortality among immigrant populations in Ontario, 1969 through 1973. Can Med Assoc J 130:399–405PubMedPubMedCentral
32.
Grulich AE, Swerdlow AJ, Head J, Marmot MG (1992) Cancer mortality in African and Carribean migrants to England and Wales. Br J Cancer 66:905–911PubMedPubMedCentral
33.
McCredie M, Williams S, Coates M (1999) Cancer mortality in East and Southeast Asian migrants to New South Wales, Australia, 1975-1995. Br J Cancer 79:1277–1282PubMedPubMedCentral
34.
McCredie M, Williams S, Coates M (1999) Cancer mortality in migrants from the British Isles and continental Europe to New South Wales, Australia, 1975-1995. Int J Cancer 83:179–185PubMed
35.
Blesch KS, Davis F, Kamath SK (1999) A comparison of breast and colon cancer incidence rates among Native Asian Indians, US immigrant Asian Indians, and whites. J Am Diet Assoc 99:1275–1277PubMed
36.
Hemminki K, Li X, Czene K (2002) Cancer risks in first-generation immigrants to Sweden. Int J Cancer 99:218–218PubMed
37.
Choe JH, Koepsell TD, Heagerty PJ, Taylor VM (2005) Colorectal cancer among Asians and Pacific Islanders in the U.S.: survival disadvantage for the foreign-born. Cancer Detect Prev 29:361–368PubMed
38.
Lee J, Demissie K, Lu S-E, Rhoads GG (2007) Cancer incidence among Korean-American immigrants in the United States and Native Koreans in South Korea. Cancer Control 14:78–85PubMed
39.
Nasseri K, Moulton LH (2011) Patterns of death in the first and second generation immigrants from selected Middle Eastern countries in California. J Immigr Minor Health 13:361–370PubMed
40.
Mousavi SM, Fallah M, Sundquist K, Hemminki K (2012) Age- and time-dependent changes in cancer incidence among immigrants to Sweden: colorectal, lung, breast, and prostate cancers. Int J Cancer 131:E122–E128PubMed
41.
Barclay KL, Goh P-J, Jackson TJ (2015) Socio-economic disadvantage and demographics as factors in stage of colorectal cancer presentation and survival. ANZ J Surg 85:135–139PubMed
42.
Ladabaum U, Clarke CA, Press DJ et al (2014) Colorectal cancer incidence in Asian populations in California: effect of nativity and neighborhood-level factors. Am J Gastrooenrol 109:579–588
43.
Tao L, Ladabaum U, Gomez SL, Cheng I (2014) Colorectal cancer mortality among Hispanics in California: differences by neighborhood socioeconomic status and nativity. Cancer 120:3510–3518PubMedPubMedCentral
44.
Feletto E, Sitas F (2015) Quantifying disparities in cancer incidence and mortality of Australian residents of New South Wales (NSW) by place of birth: an ecological study. BMC Public Health 15:823PubMedPubMedCentral
45.
Paszat L, Sutradhar R, Liu Y et al (2017) Risk of colorectal cancer among immigrants to Ontario, Canada. BMC Gastroenterol 17:85PubMedPubMedCentral
46.
Shuldiner J, Liu Y, Lofters A (2018) Incidence of breast and colorectal cancer among immigrants in Ontario, Canada: a retrospective cohort study from 2004-2014. BMC Cancer 18:537PubMedPubMedCentral
47.
Kaucher S, Kajuter H, Becher H et al (2018) Cancer incidence and mortality among ethnic German migrants from the former Soviet Union. Front Oncol 8:378PubMedPubMedCentral
48.
Villingshoj M, Ross L, Thomsen BL et al (2006) Does marital status and altered contact with the social network predict colorectal cancer survival. Eur J Cancer:42022–42027
49.
Bergelt C, Prescott E, Gronbaek M et al (2009) Social ties and risk for cancer—a prospective cohort study. Acta Oncol 48:1010–1018PubMed
50.
Wang L, Wilson SE, Stewart DB, Hollenbeak CS (2011) Marital status and colon cancer outcomes in US Surveillance, Epidemiology and End Results registries: does marriage affect cancer survival by gender and stage? Cancer Epidemiol 35:417–422PubMed
51.
Aizer AA, Chen M-H, McCarthy EP, Mendu ML, Koo S, Wilhite TJ, Graham PL, Choueiri TK, Hoffman KE, Martin NE, Hu JC, Nguyen PL (2013) Marital status and survival in patients with cancer. J Clin Oncol 31:3869–3876PubMedPubMedCentral
52.
Ikeda A, Kawachi I, Iso H, Iwasaki M, Inoue M, Tsugane S (2013) Social support and cancer incidence and mortality: the JPHC study cohort II. Cancer Causes Control 24:847–860PubMed
53.
Sarma EA, Kawachi I, Poole EM et al (2018) Social integration and survival after colorectal cancer diagnosis. Cancer 15:833–840
54.
Yang C-C, Cheng L-C, Lin Y-W et al (2019) The impact of marital status on survival in patients with surgically treated colon cancer. Medicine 98:11
55.
Dean LT, Gehlert S, Neuhouser ML, Oh A, Zanetti K, Goodman M, Thompson B, Visvanathan K, Schmitz KH (2018) Social factors matter in cancer risk and survivorship. Cancer Causes Control 29:611–618PubMedPubMedCentral
Metadata
Title
Social determinants of colorectal cancer risk, stage, and survival: a systematic review
Author
Steven S. Coughlin
Publication date
01-06-2020
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 6/2020
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-020-03585-z

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