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International Journal of Clinical Oncology

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01-05-2019 | Colorectal Cancer | Original Article

Risk factors for cardiovascular mortality in patients with colorectal cancer: a population-based study

Authors: Apostolos Gaitanidis, Michail Spathakis, Christos Tsalikidis, Michail Alevizakos, Alexandra Tsaroucha, Michail Pitiakoudis

Published in: International Journal of Clinical Oncology | Issue 5/2019

Abstract

Background

Patients with colorectal cancer are at increased risk of cardiovascular mortality compared to the general population. The purpose of this study is to identify risk factors of cardiovascular mortality in patients with colorectal cancer.

Methods

A retrospective review of the Surveillance Epidemiology and End Results (SEER) database was performed between 2010 and 2014. Standardized Mortality Ratios (SMRs) for cardiovascular mortality were calculated by comparing the number of expected deaths in the United States according to the National Center for Health Statistics (ICD-10 codes I00-I99) to the number of observed deaths in the database. Logistic regression was used to identify independent risk factors.

Results

Overall, 164,719 patients were identified (mean age at diagnosis 67 ± 13.9 years, 52.7% males, 47.3% females), of which 4854 (2.9%) died from cardiovascular disease. The majority of cardiovascular deaths occurred during the first year after diagnosis (2658, 54.8%). SMRs for cardiovascular mortality were 11.7 (95% CI 11.3–12) among all patients, 12.1 (95% CI 11.7–12.6) for male patients and 11.1 (95% CI 10.6–11.6) for female patients, with SMRs being higher for younger patients. Older age, male sex, African–American race, elevated CEA and not undergoing curative surgery were independent risk factors of cardiovascular mortality in patients with colorectal cancer.

Conclusion

Patients with colorectal cancer are associated with an increased risk of cardiovascular death, especially during the first year after diagnosis. Older age, male sex, African–American race, elevated CEA and not undergoing curative surgery are independent risk factors of cardiovascular death.

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Title: Risk factors for cardiovascular mortality in patients with colorectal cancer: a population-based study
Authors: Apostolos Gaitanidis
Michail Spathakis
Christos Tsalikidis
Michail Alevizakos
Alexandra Tsaroucha
Michail Pitiakoudis
Publication date: 01-05-2019
Publisher: Springer Singapore
Keywords: Colorectal Cancer
Colorectal Cancer
Published in: International Journal of Clinical Oncology / Issue 5/2019
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-018-01382-x

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Abstract

Background

Methods

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Conclusion

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