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Medical Molecular Morphology

Open Access 24-03-2024 | Colorectal Cancer | Original Paper

P4HA2 involved in SLUG-associated EMT predicts poor prognosis of patients with KRAS-positive colorectal cancer

Authors: Heba El-Deek Mohammed El-Deek, Maha Salah El-Naggar, Aiat Morsy Mohamed Morsy, Mayada Fawzy Sedik, Heba Ahmed Osman, Asmaa M. Ahmed

Published in: Medical Molecular Morphology

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Abstract

This study aimed to examine the immunohistochemical expression of epithelial–mesenchymal transition biomarkers: P4HA2 and SLUG in colorectal carcinoma (CRC) specimens, then to assess their relation to clinicopathological features including KRAS mutations and patients’ survival, and finally to study the correlation between them in CRC. The result of this study showed that SLUG and P4HA2 were significantly higher in association with adverse prognostic factors: presence of lympho-vascular invasion, perineural invasion, higher tumor budding, tumor stage, presence of lymph node metastasis, and presence of distant metastasis. CRC specimens with KRAS mutation were associated with significant higher SLUG and P4HA2 expression. High expression of both SLUG and P4HA2 was significantly unfavorable prognostic indicator as regards overall survival (OS) and disease-free survival (DFS). In KRAS mutated cases, high P4HA2 expression was the only significant poor prognostic indicator as regarding DFS. In conclusions, our data highlight that both SLUG and P4HA2 expression may serve as potentially important poor prognostic biomarkers in CRC and targeting these molecules may be providing a novel therapeutic strategy. In KRAS mutation group, high P4HA2 expression is the only independent prognostic factor for tumor recurrence, so it can be suggested to be a novel target for therapy.
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Metadata
Title
P4HA2 involved in SLUG-associated EMT predicts poor prognosis of patients with KRAS-positive colorectal cancer
Authors
Heba El-Deek Mohammed El-Deek
Maha Salah El-Naggar
Aiat Morsy Mohamed Morsy
Mayada Fawzy Sedik
Heba Ahmed Osman
Asmaa M. Ahmed
Publication date
24-03-2024
Publisher
Springer Nature Singapore
Published in
Medical Molecular Morphology
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI
https://doi.org/10.1007/s00795-024-00385-0