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Cancer Cell International
Published in: Cancer Cell International 1/2021

Open Access 01-12-2021 | Colorectal Cancer | Review

Epigenetic roles of PIWI proteins and piRNAs in colorectal cancer

Authors: Fatemeh Sadoughi, Seyyed Mehdi Mirhashemi, Zatollah Asemi

Published in: Cancer Cell International | Issue 1/2021

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Abstract

Small non‐coding RNAs (sncRNAs) are a subgroup of non‐coding RNAs, with less than 200 nucleotides length and no potential for coding proteins. PiRNAs, a member of sncRNAs, were first discovered more than a decade ago and have attracted researcher’s attention because of their gene regulatory function both in the nucleus and in the cytoplasm. Recent investigations have found that the abnormal expression of these sncRNAs is involved in many human diseases, including cancers. Colorectal cancer (CRC), as a common gastrointestinal malignancy, is one of the important causes of cancer‐related deaths through the entire world and appears to be a consequence of mutation in the genome and epigenetic alterations. The aim of this review is to realize whether there is a relationship between CRC and piRNAs or not.
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Metadata
Title
Epigenetic roles of PIWI proteins and piRNAs in colorectal cancer
Authors
Fatemeh Sadoughi
Seyyed Mehdi Mirhashemi
Zatollah Asemi
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2021
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-021-02034-3

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