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Familial Cancer
Published in: Familial Cancer 1/2024

04-02-2024 | Colorectal Cancer | Abstracts

CGA-IGC 2023 Abstracts

Published in: Familial Cancer | Issue 1/2024

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Excerpt

Background: Colorectal cancers in Lynch syndrome (LS) carriers, characterized by microsatellite instability (MSI) and pronounced immune infiltration, can develop via three pathways: progression from mismatch repair-proficient (MMRp) or MMR-deficient (MMRd) adenomas and MMRd crypt foci. We recently reported changes in the immune environment in normal mucosa and carcinomas from LS carriers. Here, we analyzed the LS adenoma immune phenotype and its relation to clinicopathological features with particular focus on its dependence on MMRd/MSI. …
Metadata
Title
CGA-IGC 2023 Abstracts
Publication date
04-02-2024
Publisher
Springer Netherlands
Published in
Familial Cancer / Issue 1/2024
Print ISSN: 1389-9600
Electronic ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-023-00352-1

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