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International Journal of Colorectal Disease

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Open Access 01-12-2024 | Colorectal Cancer | RESEARCH

A novel log odds of positive lymph nodes–based nomogram for predicting overall survival in patients with colorectal signet ring cell carcinoma: a SEER population-based study

Authors: Wenqian Yu, Boqi Xu, Peng Li

Published in: International Journal of Colorectal Disease | Issue 1/2024

Abstract

Purpose

Considering the poor prognosis and high lymph node (LN) involvement rate of colorectal signet ring cell carcinoma (SRCC), this study aimed to construct a prognostic nomogram to predict overall survival (OS) with satisfactory accuracy and utility, based on LN status indicators with superior predictability.

Methods

Using the Surveillance, Epidemiology, and End Results (SEER) database, we obtained cases of colorectal SRCC patients and employed univariate and multivariate Cox analyses to determine independent prognostic factors. Kaplan–Meier curves were utilized to visualize survival differences among these factors. Receiver operating characteristic curves were generated to assess predictive performances of models incorporating various LN status indicators. A novel nomogram, containing optimal LN status indicators and other prognostic factors, was developed to predict OS, whose discriminatory ability and accuracy were evaluated using calibration curves and decision curve analysis.

Results

A total of 1663 SRCC patients were screened from SEER database. Older patients and those with grades III–IV, tumor sizes > 39 mm, T3/T4 stage, N1/N2 stage, M1 stage, and higher log odds of positive lymph nodes (LODDS) values exhibited poorer prognoses. Age, grade, tumor size, TNM stage, and LODDS were independent prognostic factors. The model containing N stage and LODDS outperformed the one relying solely on N stage as LN status indicator, resulting in a validated nomogram for accurately predicting OS in SRCC patients.

Conclusion

The integration of LODDS, N stage, and other risk factors into a nomogram offered precise OS predictions, enhancing therapeutic decision-making and tailored follow-up management for colorectal SRCC patients.

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Title: A novel log odds of positive lymph nodes–based nomogram for predicting overall survival in patients with colorectal signet ring cell carcinoma: a SEER population-based study
Authors: Wenqian Yu
Boqi Xu
Peng Li
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Colorectal Cancer
Colorectal Cancer
Published in: International Journal of Colorectal Disease / Issue 1/2024
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-024-04622-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A novel log odds of positive lymph nodes–based nomogram for predicting overall survival in patients with colorectal signet ring cell carcinoma: a SEER population-based study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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