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Cellular Oncology
Published in: Cellular Oncology 1/2012

Open Access 01-02-2012 | Original Paper

Colorectal adenoma to carcinoma progression is accompanied by changes in gene expression associated with ageing, chromosomal instability, and fatty acid metabolism

Authors: Beatriz Carvalho, Anke H. Sillars-Hardebol, Cindy Postma, Sandra Mongera, Jochim Terhaar Sive Droste, Askar Obulkasim, Mark van de Wiel, Wim van Criekinge, Bauke Ylstra, Remond J. A. Fijneman, Gerrit A. Meijer

Published in: Cellular Oncology | Issue 1/2012

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Abstract

Background

Colorectal cancer develops in a multi-step manner from normal epithelium, through a pre-malignant lesion (so-called adenoma), into a malignant lesion (carcinoma), which invades surrounding tissues and eventually can spread systemically (metastasis). It is estimated that only about 5% of adenomas do progress to a carcinoma.

Aim

The present study aimed to unravel the biology of adenoma to carcinoma progression by mRNA expression profiling, and to identify candidate biomarkers for adenomas that are truly at high risk of progression.

Methods

Genome-wide mRNA expression profiles were obtained from a series of 37 colorectal adenomas and 31 colorectal carcinomas using oligonucleotide microarrays. Differentially expressed genes were validated in an independent colorectal gene expression data set. Gene Set Enrichment Analysis (GSEA) was used to identify altered expression of sets of genes associated with specific biological processes, in order to better understand the biology of colorectal adenoma to carcinoma progression.

Results

mRNA expression of 248 genes was significantly different, of which 96 were upregulated and 152 downregulated in carcinomas compared to adenomas. Classification of adenomas and carcinomas using the expression of these genes showed to be very accurate, also when tested in an independent expression data set. Gene-sets associated with ageing (which is related to senescence) and chromosomal instability were upregulated, and a gene-set associated with fatty acid metabolism was downregulated in carcinomas compared to adenomas. Moreover, gene-sets associated with chromosomal location revealed chromosome 4q22 loss and chromosome 20q gain of gene-set expression as being relevant in this progression.

Concluding remark

These data are consistent with the notion that adenomas and carcinomas are distinct biological entities. Disruption of specific biological processes like senescence (ageing), maintenance of chromosomal instability and altered metabolism, are key factors in the progression from adenoma to carcinoma.
Appendix
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Literature
1.
J. Ferlay, P. Autier, M. Boniol, M. Heanue, M. Colombet, P. Boyle, Estimates of the cancer incidence and mortality in Europe in 2006. Ann. Oncol. 18, 581–592 (2007)PubMedCrossRef
2.
T. Muto, H.J. Bussey, B.C. Morson, The evolution of cancer of the colon and rectum. Cancer 36, 2251–2270 (1975)PubMedCrossRef
3.
H. Shinya, W.I. Wolff, Morphology, anatomic distribution and cancer potential of colonic polyps. Ann. Surg. 190, 679–683 (1979)PubMedCrossRef
4.
M. Hermsen, C. Postma, J. Baak, M. Weiss, A. Rapallo, A. Sciutto, G. Roemen, J.W. Arends, R. Williams, W. Giaretti, A. De Goeij, G. Meijer, Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology 123, 1109–1119 (2002)PubMedCrossRef
5.
B. Carvalho, C. Postma, S. Mongera, E. Hopmans, S. Diskin, M.A. van de Wiel, C.W. van, O. Thas, A. Matthai, M.A. Cuesta, J.S. Terhaar Sive Droste, M. Craanen, E. Schrock, B. Ylstra, G.A. Meijer, Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression. Gut 58, 79–89 (2009)PubMedCrossRef
6.
E.R. Fearon, B. Vogelstein, A genetic model for colorectal tumorigenesis. Cell 61, 759–767 (1990)PubMedCrossRef
7.
L.D. Wood, D.W. Parsons, S. Jones, J. Lin, T. Sjoblom, R.J. Leary, D. Shen, S.M. Boca, T. Barber, J. Ptak, N. Silliman, S. Szabo, Z. Dezso, V. Ustyanksky, T. Nikolskaya, Y. Nikolsky, R. Karchin, P.A. Wilson, J.S. Kaminker, Z. Zhang, R. Croshaw, J. Willis, D. Dawson, M. Shipitsin, J.K. Willson, S. Sukumar, K. Polyak, B.H. Park, C.L. Pethiyagoda, P.V. Pant, D.G. Ballinger, A.B. Sparks, J. Hartigan, D.R. Smith, E. Suh, N. Papadopoulos, P. Buckhaults, S.D. Markowitz, G. Parmigiani, K.W. Kinzler, V.E. Velculescu, B. Vogelstein, The genomic landscapes of human breast and colorectal cancers. Science 318, 1108–1113 (2007)PubMedCrossRef
8.
R.J. Leary, J.C. Lin, J. Cummins, S. Boca, L.D. Wood, D.W. Parsons, S. Jones, T. Sjoblom, B.H. Park, R. Parsons, J. Willis, D. Dawson, J.K. Willson, T. Nikolskaya, Y. Nikolsky, L. Kopelovich, N. Papadopoulos, L.A. Pennacchio, T.L. Wang, S.D. Markowitz, G. Parmigiani, K.W. Kinzler, B. Vogelstein, V.E. Velculescu, Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc. Natl. Acad. Sci. U. S. A. 105, 16224–16229 (2008)PubMedCrossRef
9.
R.P. Brosens, J.C. Haan, B. Carvalho, F. Rustenburg, H. Grabsch, P. Quirke, A.F. Engel, M.A. Cuesta, N. Maughan, M. Flens, G.A. Meijer, B. Ylstra, Candidate driver genes in focal chromosomal aberrations of stage II colon cancer. J. Pathol. 221, 411–424 (2010)PubMed
10.
T.A. Chan, S. Glockner, J.M. Yi, W. Chen, N.L. Van, L. Cope, J.G. Herman, V. Velculescu, K.E. Schuebel, N. Ahuja, S.B. Baylin, Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. PLoS. Med. 5, e114 (2008)PubMedCrossRef
11.
J.R. Bischoff, L. Anderson, Y. Zhu, K. Mossie, L. Ng, B. Souza, B. Schryver, P. Flanagan, F. Clairvoyant, C. Ginther, C.S. Chan, M. Novotny, D.J. Slamon, G.D. Plowman, A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052–3065 (1998)PubMedCrossRef
12.
A.K. Lam, K. Ong, Y.H. Ho, Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity. Hum. Pathol. 39, 599–604 (2008)PubMedCrossRef
13.
T. Macarulla, F.J. Ramos, J. Tabernero, Aurora kinase family: a new target for anticancer drug. Recent Pat. Anticancer Drug Discov. 3, 114–122 (2008)PubMedCrossRef
14.
O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, M.E. Nita, T. Takagi, Y. Nakamura, T. Tsunoda, Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia. Cancer Res. 61, 3544–3549 (2001)PubMed
15.
T.T. Zou, F.M. Selaru, Y. Xu, V. Shustova, J. Yin, Y. Mori, D. Shibata, F. Sato, S. Wang, A. Olaru, E. Deacu, T.C. Liu, J.M. Abraham, S.J. Meltzer, Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. Oncogene 21, 4855–4862 (2002)PubMedCrossRef
16.
K. Birkenkamp-Demtroder, L.L. Christensen, S.H. Olesen, C.M. Frederiksen, P. Laiho, L.A. Aaltonen, S. Laurberg, F.B. Sorensen, R. Hagemann, T.F. ORntoft, Gene expression in colorectal cancer. Cancer Res. 62, 4352–4363 (2002)PubMed
17.
F. Bertucci, S. Salas, S. Eysteries, V. Nasser, P. Finetti, C. Ginestier, E. Charafe-Jauffret, B. Loriod, L. Bachelart, J. Montfort, G. Victorero, F. Viret, V. Ollendorff, V. Fert, M. Giovaninni, J.R. Delpero, C. Nguyen, P. Viens, G. Monges, D. Birnbaum, R. Houlgatte, Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters. Oncogene 23, 1377–1391 (2004)PubMedCrossRef
18.
M. Bianchini, E. Levy, C. Zucchini, V. Pinski, C. Macagno, S.P. De, L. Valvassori, P. Carinci, J. Mordoh, Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa. Int. J. Oncol. 29, 83–94 (2006)PubMed
19.
C.P. Giacomini, S.Y. Leung, X. Chen, S.T. Yuen, Y.H. Kim, E. Bair, J.R. Pollack, A gene expression signature of genetic instability in colon cancer. Cancer Res. 65, 9200–9205 (2005)PubMedCrossRef
20.
M. Kruhoffer, J.L. Jensen, P. Laiho, L. Dyrskjot, R. Salovaara, D. Arango, K. Birkenkamp-Demtroder, F.B. Sorensen, L.L. Christensen, L. Buhl, J.P. Mecklin, H. Jarvinen, T. Thykjaer, F.P. Wikman, F. Bech-Knudsen, M. Juhola, N.N. Nupponen, S. Laurberg, C.L. Andersen, L.A. Aaltonen, T.F. ORntoft, Gene expression signatures for colorectal cancer microsatellite status and HNPCC. Br. J. Cancer 92, 2240–2248 (2005)PubMedCrossRef
21.
P. Hegde, R. Qi, R. Gaspard, K. Abernathy, S. Dharap, J. Earle-Hughes, C. Gay, N.U. Nwokekeh, T. Chen, A.I. Saeed, V. Sharov, N.H. Lee, T.J. Yeatman, J. Quackenbush, Identification of tumor markers in models of human colorectal cancer using a 19,200-element complementary DNA microarray. Cancer Res. 61, 7792–7797 (2001)PubMed
22.
O. Takata, Y.J. Kawamura, F. Konishi, J. Sasaki, T. Kai, Y. Miyakura, H. Nagai, T. Tsukamoto, cDNA array analysis for prediction of hepatic metastasis of colorectal carcinoma. Surg. Today. 36, 608–614 (2006)PubMedCrossRef
23.
G.A. Ganepola, R.M. Mazziotta, D. Weeresinghe, G.A. Corner, C.J. Parish, D.H. Chang, N.C. Tebbutt, C. Murone, N. Ahmed, L.H. Augenlicht, J.M. Mariadason, Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors. Clin. Exp. Metastasis. 27, 1–9 (2010)PubMedCrossRef
24.
K.H. Koh, H. Rhee, H.J. Kang, E. Yang, K.T. You, H. Lee, B.S. Min, N.K. Kim, S.W. Nam, H. Kim, Differential gene expression profiles of metastases in paired primary and metastatic colorectal carcinomas. Oncology 75, 92–101 (2008)PubMedCrossRef
25.
M. Grade, P. Hormann, S. Becker, A.B. Hummon, D. Wangsa, S. Varma, R. Simon, T. Liersch, H. Becker, M.J. Difilippantonio, B.M. Ghadimi, T. Ried, Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. Cancer Res. 67, 41–56 (2007)PubMedCrossRef
26.
A. Barrier, P.Y. Boelle, A. Lemoine, C. Tse, D. Brault, F. Chiappini, F. Lacaine, S. Houry, M. Huguier, A. Flahault, S. Dudoit, Gene expression profiling of nonneoplastic mucosa may predict clinical outcome of colon cancer patients. Dis. Colon Rectum 48, 2238–2248 (2005)PubMedCrossRef
27.
D. Arango, P. Laiho, A. Kokko, P. Alhopuro, H. Sammalkorpi, R. Salovaara, D. Nicorici, S. Hautaniemi, H. Alazzouzi, J.P. Mecklin, H. Jarvinen, A. Hemminki, J. Astola, Schwartz S Jr, L.A. Aaltonen, Gene-expression profiling predicts recurrence in Dukes’ C colorectal cancer. Gastroenterology 129, 874–884 (2005)PubMedCrossRef
28.
E. Bandrés, R. Malumbres, E. Cubedo, B. Honorato, R. Zarate, A. Labarga, U. Gabisu, J.J. Sola, J. Garcia-Foncillas, A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes’ B colon cancer patients. Oncol. Rep. 17, 1089–1094 (2007)PubMed
29.
A. Barrier, P.Y. Boelle, F. Roser, J. Gregg, C. Tse, D. Brault, F. Lacaine, S. Houry, M. Huguier, B. Franc, A. Flahault, A. Lemoine, S. Dudoit, Stage II colon cancer prognosis prediction by tumor gene expression profiling. J. Clin. Oncol. 24, 4685–4691 (2006)PubMedCrossRef
30.
M. Del Rio, F. Molina, C. Bascoul-Mollevi, V. Copois, F. Bibeau, P. Chalbos, C. Bareil, A. Kramar, N. Salvetat, C. Fraslon, E. Conseiller, V. Granci, B. Leblanc, B. Pau, P. Martineau, M. Ychou, Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan. J. Clin. Oncol. 25, 773–780 (2007)PubMedCrossRef
31.
D.A. Notterman, U. Alon, A.J. Sierk, A.J. Levine, Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res. 61, 3124–3130 (2001)PubMed
32.
Y.M. Lin, Y. Furukawa, T. Tsunoda, C.T. Yue, K.C. Yang, Y. Nakamura, Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas. Oncogene 21, 4120–4128 (2002)PubMedCrossRef
33.
O. Galamb, B. Gyorffy, F. Sipos, S. Spisak, A.M. Nemeth, P. Miheller, Z. Tulassay, E. Dinya, B. Molnar, Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature. Dis. Markers. 25, 1–16 (2008)PubMed
34.
M. Skrzypczak, K. Goryca, T. Rubel, A. Paziewska, M. Mikula, D. Jarosz, J. Pachlewski, J. Oledzki, J. Ostrowski, Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS. One. 5 (2010)
35.
A.H. Sillars-Hardebol, B. Carvalho, M. de Wit, C. Postma, P.M. Delis-van Diemen, S. Mongera, B. Ylstra, M.A. van de Wiel, G.A. Meijer, R.J. Fijneman, Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression. Tumour. Biol. 31, 89–96 (2010)PubMedCrossRef
36.
R. Edgar, M. Domrachev, A.E. Lash, Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30, 207–210 (2002)PubMedCrossRef
37.
R. Tibshirani, T. Hastie, B. Narasimhan, G. Chu, Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc. Natl. Acad. Sci. U. S. A. 99, 6567–6572 (2002)PubMedCrossRef
38.
A. Subramanian, P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, E.S. Lander, J.P. Mesirov, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U. S. A. 102, 15545–15550 (2005)PubMedCrossRef
39.
D. Huang, B. Yu, Y. Deng, W. Sheng, Z. Peng, W. Qin, X. Du, SFRP4 was overexpressed in colorectal carcinoma. J. Cancer Res. Clin. Oncol. 136, 395–401 (2010)PubMedCrossRef
40.
U. Gerlach, G. Kayser, A. Walch, U. Hopt, J. Schulte-Monting, M. Werner, S. Lassmann, Centrosome-, chromosomal-passenger- and cell-cycle-associated mRNAs are differentially regulated in the development of sporadic colorectal cancer. J. Pathol. 208, 462–472 (2006)PubMedCrossRef
41.
C. Grijelmo, C. Rodrigue, M. Svrcek, E. Bruyneel, A. Hendrix, W.O. de, C. Gespach, Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. Cell. Signal. 19, 1722–1732 (2007)PubMedCrossRef
42.
T. Tomonaga, K. Matsushita, M. Ishibashi, M. Nezu, H. Shimada, T. Ochiai, K. Yoda, F. Nomura, Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. Cancer Res. 65, 4683–4689 (2005)PubMedCrossRef
43.
J. Murn, O. Alibert, N. Wu, S. Tendil, X. Gidrol, Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4. J. Exp. Med. 205, 3091–3103 (2008)PubMedCrossRef
44.
J.P. Carey, A.J. Asirvatham, O. Galm, T.A. Ghogomu, J. Chaudhary, Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer. BMC Cancer. 9, 173 (2009)PubMedCrossRef
45.
T.L. Romanuik, T. Ueda, N. Le, S. Haile, T.M. Yong, T. Thomson, R.L. Vessella, M.D. Sadar, Novel biomarkers for prostate cancer including noncoding transcripts. Am. J. Pathol. 175, 2264–2276 (2009)PubMedCrossRef
46.
N. Miyoshi, H. Ishii, M. Sekimoto, Y. Doki, M. Mori, RGS16 is a marker for prognosis in colorectal cancer. Ann. Surg. Oncol. 16, 3507–3514 (2009)PubMedCrossRef
47.
K.A. Rees, H. Singh, N.P. Brindle, The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. Int. J. Oncol. 31, 893–897 (2007)PubMed
48.
L. Tang, D.L. Dai, M. Su, M. Martinka, G. Li, Y. Zhou, Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. Clin. Cancer Res. 12, 3716–3722 (2006)PubMedCrossRef
49.
K. Yamaguchi, M. Sakai, T. Shimokawa, Y. Yamada, Y. Nakamura, Y. Furukawa, C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer. Br. J. Cancer 102, 325–331 (2010)PubMedCrossRef
50.
H. Satake, K. Tamura, M. Furihata, T. Anchi, H. Sakoda, C. Kawada, T. Iiyama, S. Ashida, T. Shuin, The ubiquitin-like molecule interferon-stimulated gene 15 is overexpressed in human prostate cancer. Oncol. Rep. 23, 11–16 (2010)PubMed
51.
J. Li, R. Sun, K. Tao, G. Wang, The CCL21/CCR7 pathway plays a key role in human colon cancer metastasis through regulation of matrix metalloproteinase-9. Dig. Liver Dis. (2010)
52.
K. Dardousis, C. Voolstra, M. Roengvoraphoj, A. Sekandarzad, S. Mesghenna, J. Winkler, Y. Ko, J. Hescheler, A. Sachinidis, Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells. Mol. Ther. 15, 94–102 (2007)PubMedCrossRef
53.
R. Read, G. Hansen, J. Kramer, R. Finch, L. Li, P. Vogel, Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest. Vet. Pathol. 46, 491–504 (2009)PubMedCrossRef
54.
S. Ghosh, A. Ghosh, G.P. Maiti, N. Alam, A. Roy, B. Roy, S. Roychoudhury, C.K. Panda, Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis. Int. J. Cancer 123, 2594–2604 (2008)PubMedCrossRef
55.
R.A. Hubner, K.R. Muir, J.F. Liu, R.F. Logan, M. Grainge, N. Armitage, V. Shepherd, S. Popat, R.S. Houlston, Genetic variants of UGT1A6 influence risk of colorectal adenoma recurrence. Clin. Cancer Res. 12, 6585–6589 (2006)PubMedCrossRef
56.
T. Santarius, J. Shipley, D. Brewer, M.R. Stratton, C.S. Cooper, A census of amplified and overexpressed human cancer genes. Nat. Rev. Cancer 10, 59–64 (2010)PubMedCrossRef
57.
S. Sen, H. Katayama, K. Sasai, Functional significance of Aurora kinase A in centrosome amplification and genomic instability. Adv. Exp. Med. Biol. 617, 99–108 (2008)PubMedCrossRef
58.
H. Zhou, J. Kuang, L. Zhong, W.L. Kuo, J.W. Gray, A. Sahin, B.R. Brinkley, S. Sen, Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20, 189–193 (1998)PubMedCrossRef
59.
J. Chen, L. Ye, F. Xie, Y. Yang, L. Zhang, W.G. Jiang, Expression of bone morphogenetic protein 7 in lung cancer and its biological impact on lung cancer cells. Anticancer. Res. 30, 1113–1120 (2010)PubMed
60.
C. Morrissey, L.G. Brown, T.E. Pitts, R.L. Vessella, E. Corey, Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. Neoplasia 12, 192–205 (2010)PubMed
61.
E.L. Alarmo, J. Parssinen, J.M. Ketolainen, K. Savinainen, R. Karhu, A. Kallioniemi, BMP7 influences proliferation, migration, and invasion of breast cancer cells. Cancer Lett. 275, 35–43 (2009)PubMedCrossRef
62.
L. Cassar, H. Li, A.R. Pinto, C. Nicholls, S. Bayne, J.P. Liu, Bone morphogenetic protein-7 inhibits telomerase activity, telomere maintenance, and cervical tumor growth. Cancer Res. 68, 9157–9166 (2008)PubMedCrossRef
63.
K. Motoyama, F. Tanaka, Y. Kosaka, K. Mimori, H. Uetake, H. Inoue, K. Sugihara, M. Mori, Clinical significance of BMP7 in human colorectal cancer. Ann. Surg. Oncol. 15, 1530–1537 (2008)PubMedCrossRef
64.
65.
T. Kuilman, C. Michaloglou, W.J. Mooi, D.S. Peeper, The essence of senescence. Genes Dev. 24, 2463–2479 (2010)PubMedCrossRef
66.
W.J. Mooi, D.S. Peeper, Oncogene-induced cell senescence–halting on the road to cancer. N. Engl. J. Med. 355, 1037–1046 (2006)PubMedCrossRef
67.
M.T. Hemann, M. Narita, Oncogenes and senescence: breaking down in the fast lane. Genes Dev. 21, 1–5 (2007)PubMedCrossRef
68.
L.C. Vredeveld, B.D. Rowland, S. Douma, R. Bernards, D.S. Peeper, Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E. Carcinogenesis 31, 201–207 (2010)PubMedCrossRef
69.
A.R. Davalos, J.P. Coppe, J. Campisi, P.Y. Desprez, Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 29, 273–283 (2010)PubMedCrossRef
70.
D. Wang, R.N. DuBois, Pro-inflammatory prostaglandins and progression of colorectal cancer. Cancer Lett. 267, 197–203 (2008)PubMedCrossRef
71.
H. Rajagopalan, M.A. Nowak, B. Vogelstein, C. Lengauer, The significance of unstable chromosomes in colorectal cancer. Nat. Rev. Cancer 3, 695–701 (2003)PubMedCrossRef
72.
R.J. Fijneman, B. Carvalho, C. Postma, S. Mongera, V.W. van Hinsbergh, G.A. Meijer, Loss of 1p36, gain of 8q24, and loss of 9q34 are associated with stroma percentage of colorectal cancer. Cancer Lett. 258, 223–229 (2007)PubMedCrossRef
73.
R.J. Deberardinis, N. Sayed, D. Ditsworth, C.B. Thompson, Brick by brick: metabolism and tumor cell growth. Curr. Opin. Genet. Dev. 18, 54–61 (2008)PubMedCrossRef
74.
I. Samudio, R. Harmancey, M. Fiegl, H. Kantarjian, M. Konopleva, B. Korchin, K. Kaluarachchi, W. Bornmann, S. Duvvuri, H. Taegtmeyer, M. Andreeff, Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J. Clin. Invest. 120, 142–156 (2010)PubMedCrossRef
75.
V. Fritz, L. Fajas, Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene 29, 4369–4377 (2010)PubMedCrossRef
76.
N. Homann, I.R. Konig, M. Marks, M. Benesova, F. Stickel, G. Millonig, S. Mueller, H.K. Seitz, Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1 C polymorphism. Alcohol. Clin. Exp. Res. 33, 551–556 (2009)PubMedCrossRef
77.
E.J. Douglas, H. Fiegler, A. Rowan, S. Halford, D.C. Bicknell, W. Bodmer, I.P. Tomlinson, N.P. Carter, Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas. Cancer Res. 64, 4817–4825 (2004)PubMedCrossRef
78.
R.P. Brosens, E.J. Belt, J.C. Haan, T.E. Buffart, B. Carvalho, H. Grabsch, P. Quirke, M.A. Cuesta, A.F. Engel, B. Ylstra, G.A. Meijer, Deletion of chromosome 4q predicts outcome in stage II colon cancer patients. Cell. Oncol. 34, 215–223 (2011)CrossRef
Metadata
Title
Colorectal adenoma to carcinoma progression is accompanied by changes in gene expression associated with ageing, chromosomal instability, and fatty acid metabolism
Authors
Beatriz Carvalho
Anke H. Sillars-Hardebol
Cindy Postma
Sandra Mongera
Jochim Terhaar Sive Droste
Askar Obulkasim
Mark van de Wiel
Wim van Criekinge
Bauke Ylstra
Remond J. A. Fijneman
Gerrit A. Meijer
Publication date
01-02-2012
Publisher
Springer Netherlands
Published in
Cellular Oncology / Issue 1/2012
Print ISSN: 2211-3428
Electronic ISSN: 2211-3436
DOI
https://doi.org/10.1007/s13402-011-0065-1

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Reviewers 2011

Original Paper

The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

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Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
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