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Discover Oncology
Published in: Discover Oncology 1/2023

Open Access 01-12-2023 | Colon Cancer | Research

Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells

Authors: Rong Li, Dongmei Wang, Huijuan Li, Xianhua Lei, Weilian Liao, Xiao-Yu Liu

Published in: Discover Oncology | Issue 1/2023

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Abstract

Colon cancer is a common malignancy of the digestive tract. Colon cancer stem-like cells (CCSCs) are theoretically one of the key drivers of the initiation, relapse, metastasis, and chemo-resistance of colon tumors. Piezo1 is a mechanosensitive cationic channel protein involved in cancer progression. However, little is known regarding the possible role of Piezo1 in maintaining the stemness of CCSCs. In this study, we found that Piezo1 was highly expressed in CD133+/CD44+ colon cancer tissues, and the Piezo1high/CD133+CD44+ population was associated with the clinical stage. Furthermore, CCSCs isolated from colon cell lines expressed higher Piezo1 levels compared to the non-CCSCs, and Piezo1 knockdown inhibited their tumorigenicity and self-renewal capacity. Mechanistically, Piezo1 maintained the stemness of CCSCs through Ca2+/NFAT1 signaling, and knocking down Piezo1 promoted degradation of NFAT1. Taken together, Piezo1 is involved in the stage of colon cancer and is a promising therapeutic target.
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Metadata
Title
Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells
Authors
Rong Li
Dongmei Wang
Huijuan Li
Xianhua Lei
Weilian Liao
Xiao-Yu Liu
Publication date
01-12-2023
Publisher
Springer US
Published in
Discover Oncology / Issue 1/2023
Print ISSN: 1868-8497
Electronic ISSN: 2730-6011
DOI
https://doi.org/10.1007/s12672-023-00712-4

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