Skip to main content
Top
Published in: CardioVascular and Interventional Radiology 3/2014

01-06-2014 | Clinical Investigation

Coil-Assisted RFA of Poorly Visible Liver Tumors: Effectiveness and Risk Factors of Local Tumor Progression

Authors: Geoffroy Farouil, Frederic Deschamps, Antoine Hakime, Thierry de Baere

Published in: CardioVascular and Interventional Radiology | Issue 3/2014

Login to get access

Abstract

Objectives

This study was designed to determine the effectiveness of a percutaneously inserted coil as a landmark before radiofrequency ablation (RFA) of poorly visible liver tumors on unenhanced computed tomography and ultrasound.

Methods

This was a single-center, retrospective study of 46 consecutive patients treated from January 2008 to June 2012 with RFA under CT guidance for 57 poorly visible liver tumors after percutaneous coil insertion. Effectiveness was evaluated by the rate of local tumor progression (LTP), and the risk factors of LTP were evaluated by multiple univariate analysis.

Results

After a mean follow-up of 15.9 months, the overall rate of LTP was 22.8 % (13/57). An increase in the distance between the coil and the center of the tumor was a predictive factor of LTP (p = 0.005) and resulted in an increase in time to place the RFA probe. LTP was significantly reduced in case of coil placed within the tumor (10 vs. 43.5 %, p = 0.009).

Conclusions

The effectiveness of the “coil-assisted” RFA for poorly visible liver tumors is improved by centering the coil in the tumor in order to facilitate the placement of the RFA probe and equal to the results of RFA under direct image guidance.
Literature
1.
go back to reference Feng K, Yan J, Li X et al (2012) A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma. J Hepatol 57(4):794–802PubMedCrossRef Feng K, Yan J, Li X et al (2012) A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma. J Hepatol 57(4):794–802PubMedCrossRef
2.
go back to reference Cirocchi R, Trastulli S, Boselli C et al (2012) Radiofrequency ablation in the treatment of liver metastases from colorectal cancer. Cochrane Database Syst Rev 6:CD006317PubMed Cirocchi R, Trastulli S, Boselli C et al (2012) Radiofrequency ablation in the treatment of liver metastases from colorectal cancer. Cochrane Database Syst Rev 6:CD006317PubMed
3.
go back to reference Sato M, Watanabe Y, Tokui K, Kawachi K, Sugata S, Ikezoe J (2000) CT-guided treatment of ultrasonically invisible hepatocellular carcinoma. Am J Gastroenterol 95(8):2102–2106PubMedCrossRef Sato M, Watanabe Y, Tokui K, Kawachi K, Sugata S, Ikezoe J (2000) CT-guided treatment of ultrasonically invisible hepatocellular carcinoma. Am J Gastroenterol 95(8):2102–2106PubMedCrossRef
4.
go back to reference Park BJ, Byun JH, Jin YH et al (2009) CT-guided radiofrequency ablation for hepatocellular carcinomas that were undetectable at US: therapeutic effectiveness and safety. J Vasc Interv Radiol 20(4):490–499PubMedCrossRef Park BJ, Byun JH, Jin YH et al (2009) CT-guided radiofrequency ablation for hepatocellular carcinomas that were undetectable at US: therapeutic effectiveness and safety. J Vasc Interv Radiol 20(4):490–499PubMedCrossRef
5.
go back to reference Stattaus J, Kuehl H, Ladd S et al (2007) CT-guided biopsy of small liver lesions: visibility, artifacts, and corresponding diagnostic accuracy. Cardiovasc Intervent Radiol 30(5):928–935PubMedCrossRef Stattaus J, Kuehl H, Ladd S et al (2007) CT-guided biopsy of small liver lesions: visibility, artifacts, and corresponding diagnostic accuracy. Cardiovasc Intervent Radiol 30(5):928–935PubMedCrossRef
6.
go back to reference Adam A, Hatzidakis A, Hamady M, Sabharwal T, Gangi A (2004) Percutaneous coil placement prior to radiofrequency ablation of poorly visible hepatic tumors. Eur Radiol 14(9):1688–1691PubMedCrossRef Adam A, Hatzidakis A, Hamady M, Sabharwal T, Gangi A (2004) Percutaneous coil placement prior to radiofrequency ablation of poorly visible hepatic tumors. Eur Radiol 14(9):1688–1691PubMedCrossRef
7.
go back to reference Goldberg SN, Grassi CJ, Cardella JF et al (2009) Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 20(7 Suppl):S377–S390PubMedCrossRef Goldberg SN, Grassi CJ, Cardella JF et al (2009) Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 20(7 Suppl):S377–S390PubMedCrossRef
8.
go back to reference Boll DT, Lewin JS, Duerk JL, Merkle EM (2003) Do surgical clips interfere with radiofrequency thermal ablation? AJR Am J Roentgenol 180(6):1557–1560PubMedCrossRef Boll DT, Lewin JS, Duerk JL, Merkle EM (2003) Do surgical clips interfere with radiofrequency thermal ablation? AJR Am J Roentgenol 180(6):1557–1560PubMedCrossRef
9.
go back to reference Hohmann J, Albrecht T, Hoffmann CW, Wolf KJ (2003) Ultrasonographic detection of focal liver lesions: increased sensitivity and specificity with microbubble contrast agents. Eur J Radiol 46(2):147–159PubMedCrossRef Hohmann J, Albrecht T, Hoffmann CW, Wolf KJ (2003) Ultrasonographic detection of focal liver lesions: increased sensitivity and specificity with microbubble contrast agents. Eur J Radiol 46(2):147–159PubMedCrossRef
10.
go back to reference Rhim H, Lee MH, Kim YS, Choi D, Lee WJ, Lim HK (2008) Planning sonography to assess the feasibility of percutaneous radiofrequency ablation of hepatocellular carcinomas. AJR Am J Roentgenol 190(5):1324–1330PubMedCrossRef Rhim H, Lee MH, Kim YS, Choi D, Lee WJ, Lim HK (2008) Planning sonography to assess the feasibility of percutaneous radiofrequency ablation of hepatocellular carcinomas. AJR Am J Roentgenol 190(5):1324–1330PubMedCrossRef
11.
go back to reference Lee MW, Kim YJ, Park HS et al (2010) Targeted sonography for small hepatocellular carcinoma discovered by CT or MRI: factors affecting sonographic detection. AJR Am J Roentgenol 194(5):W396–W400PubMedCrossRef Lee MW, Kim YJ, Park HS et al (2010) Targeted sonography for small hepatocellular carcinoma discovered by CT or MRI: factors affecting sonographic detection. AJR Am J Roentgenol 194(5):W396–W400PubMedCrossRef
12.
go back to reference Kim PN, Choi D, Rhim H et al (2012) Planning ultrasound for percutaneous radiofrequency ablation to treat small (≤3 cm) hepatocellular carcinomas detected on computed tomography or magnetic resonance imaging: a multicenter prospective study to assess factors affecting ultrasound visibility. J Vasc Interv Radiol 23(5):627–634PubMedCrossRef Kim PN, Choi D, Rhim H et al (2012) Planning ultrasound for percutaneous radiofrequency ablation to treat small (≤3 cm) hepatocellular carcinomas detected on computed tomography or magnetic resonance imaging: a multicenter prospective study to assess factors affecting ultrasound visibility. J Vasc Interv Radiol 23(5):627–634PubMedCrossRef
13.
go back to reference de Baere T, Dromain C, Lapeyre M et al (2005) Artificially induced pneumothorax for percutaneous transthoracic radiofrequency ablation of tumors in the hepatic dome: initial experience. Radiology 236(2):666–670PubMedCrossRef de Baere T, Dromain C, Lapeyre M et al (2005) Artificially induced pneumothorax for percutaneous transthoracic radiofrequency ablation of tumors in the hepatic dome: initial experience. Radiology 236(2):666–670PubMedCrossRef
14.
go back to reference Wang ZY, Sun WB, Li MY, Zhang XX, Ding XM (2008) Percutaneous extrapulmonary radiofrequency ablation for tumors in the hepatic dome. Hepatogastroenterology 55(85):1164–1166PubMed Wang ZY, Sun WB, Li MY, Zhang XX, Ding XM (2008) Percutaneous extrapulmonary radiofrequency ablation for tumors in the hepatic dome. Hepatogastroenterology 55(85):1164–1166PubMed
15.
go back to reference Schweiger GD, Brown BP, Pelsang RE, Dhadha RS, Barloon TJ, Wang G (2000) CT fluoroscopy: technique and utility in guiding biopsies of transiently enhancing hepatic masses. Abdom Imaging 25(1):81–85PubMedCrossRef Schweiger GD, Brown BP, Pelsang RE, Dhadha RS, Barloon TJ, Wang G (2000) CT fluoroscopy: technique and utility in guiding biopsies of transiently enhancing hepatic masses. Abdom Imaging 25(1):81–85PubMedCrossRef
16.
go back to reference Solomon SB, Bohlman ME, Choti MA (2002) Percutaneous gadolinium injection under MR guidance to mark target for CT-guided radiofrequency ablation. J Vasc Interv Radiol 13(4):419–421PubMedCrossRef Solomon SB, Bohlman ME, Choti MA (2002) Percutaneous gadolinium injection under MR guidance to mark target for CT-guided radiofrequency ablation. J Vasc Interv Radiol 13(4):419–421PubMedCrossRef
17.
go back to reference Prior JO, Kosinski M, Delaloye AB, Denys A (2007) Initial report of PET/CT-guided radiofrequency ablation of liver metastases. J Vasc Interv Radiol 18(6):801–803PubMedCrossRef Prior JO, Kosinski M, Delaloye AB, Denys A (2007) Initial report of PET/CT-guided radiofrequency ablation of liver metastases. J Vasc Interv Radiol 18(6):801–803PubMedCrossRef
18.
go back to reference Hakime A, Deschamps F, De Carvalho EG, Teriitehau C, Auperin A, De Baere T (2011) Clinical evaluation of spatial accuracy of a fusion imaging technique combining previously acquired computed tomography and real-time ultrasound for imaging of liver metastases. Cardiovasc Intervent Radiol 34(2):338–344PubMedCrossRef Hakime A, Deschamps F, De Carvalho EG, Teriitehau C, Auperin A, De Baere T (2011) Clinical evaluation of spatial accuracy of a fusion imaging technique combining previously acquired computed tomography and real-time ultrasound for imaging of liver metastases. Cardiovasc Intervent Radiol 34(2):338–344PubMedCrossRef
19.
go back to reference Lee MW, Rhim H, Cha DI et al (2012) Percutaneous radiofrequency ablation of hepatocellular carcinoma: fusion imaging guidance for management of lesions with poor conspicuity at conventional sonography. AJR Am J Roentgenol 198(6):1438–1444PubMedCrossRef Lee MW, Rhim H, Cha DI et al (2012) Percutaneous radiofrequency ablation of hepatocellular carcinoma: fusion imaging guidance for management of lesions with poor conspicuity at conventional sonography. AJR Am J Roentgenol 198(6):1438–1444PubMedCrossRef
20.
go back to reference Minami Y, Chung H, Kudo M et al (2008) Radiofrequency ablation of hepatocellular carcinoma: value of virtual CT sonography with magnetic navigation. AJR Am J Roentgenol 190(6):W335–W341PubMedCrossRef Minami Y, Chung H, Kudo M et al (2008) Radiofrequency ablation of hepatocellular carcinoma: value of virtual CT sonography with magnetic navigation. AJR Am J Roentgenol 190(6):W335–W341PubMedCrossRef
21.
go back to reference Nakai M, Sato M, Sahara S et al (2009) Radiofrequency ablation assisted by real-time virtual sonography and CT for hepatocellular carcinoma undetectable by conventional sonography. Cardiovasc Intervent Radiol 32(1):62–69PubMedCrossRef Nakai M, Sato M, Sahara S et al (2009) Radiofrequency ablation assisted by real-time virtual sonography and CT for hepatocellular carcinoma undetectable by conventional sonography. Cardiovasc Intervent Radiol 32(1):62–69PubMedCrossRef
22.
go back to reference Pietryga JA, Beland MD, Dupuy DE, Mayo-Smith WW (2012) Placement of marker coils at biopsy: usefulness in the localization of poorly visualized renal neoplasms for subsequent CT-guided radiofrequency ablation. Radiology 263(2):555–561PubMedCrossRef Pietryga JA, Beland MD, Dupuy DE, Mayo-Smith WW (2012) Placement of marker coils at biopsy: usefulness in the localization of poorly visualized renal neoplasms for subsequent CT-guided radiofrequency ablation. Radiology 263(2):555–561PubMedCrossRef
23.
go back to reference de Baere T, Deschamps F, Briggs P et al (2008) Hepatic malignancies: percutaneous radiofrequency ablation during percutaneous portal or hepatic vein occlusion. Radiology 248(3):1056–1066PubMedCrossRef de Baere T, Deschamps F, Briggs P et al (2008) Hepatic malignancies: percutaneous radiofrequency ablation during percutaneous portal or hepatic vein occlusion. Radiology 248(3):1056–1066PubMedCrossRef
24.
go back to reference de Baere T, Elias D, Dromain C et al (2000) Radiofrequency ablation of 100 hepatic metastases with a mean follow-up of more than 1 year. AJR Am J Roentgenol 175(6):1619–1625PubMedCrossRef de Baere T, Elias D, Dromain C et al (2000) Radiofrequency ablation of 100 hepatic metastases with a mean follow-up of more than 1 year. AJR Am J Roentgenol 175(6):1619–1625PubMedCrossRef
25.
go back to reference Nakazawa T, Kokubu S, Shibuya A et al (2007) Radiofrequency ablation of hepatocellular carcinoma: correlation between local tumor progression after ablation and ablative margin. AJR Am J Roentgenol 188(2):480–488PubMedCrossRef Nakazawa T, Kokubu S, Shibuya A et al (2007) Radiofrequency ablation of hepatocellular carcinoma: correlation between local tumor progression after ablation and ablative margin. AJR Am J Roentgenol 188(2):480–488PubMedCrossRef
26.
go back to reference Petsas T, Tsota I, Kalogeropoulou CP, Liatsikos EN (2007) Application of a new guiding system in percutaneous biopsies. Cardiovasc Intervent Radiol 30(2):276–280PubMedCrossRef Petsas T, Tsota I, Kalogeropoulou CP, Liatsikos EN (2007) Application of a new guiding system in percutaneous biopsies. Cardiovasc Intervent Radiol 30(2):276–280PubMedCrossRef
Metadata
Title
Coil-Assisted RFA of Poorly Visible Liver Tumors: Effectiveness and Risk Factors of Local Tumor Progression
Authors
Geoffroy Farouil
Frederic Deschamps
Antoine Hakime
Thierry de Baere
Publication date
01-06-2014
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 3/2014
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-013-0717-9

Other articles of this Issue 3/2014

CardioVascular and Interventional Radiology 3/2014 Go to the issue