Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ASCO Annual Meeting 2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

2024 ASCO Annual Meeting

Keep up to date with all the top stories and latest evidence with our hub page, including official congress videos and expert takeaways.
ADVANCED SEARCH
Log in
Top
Journal of Immigrant and Minority Health
Published in: Journal of Immigrant and Minority Health 3/2018

01-06-2018 | Original Paper

Cognitive Function and Vascular Risk Factors Among Older African American Adults

Authors: Ishan C. Williams, Moon Ho Park, Siny Tsang, Scott A. Sperling, Carol Manning

Published in: Journal of Immigrant and Minority Health | Issue 3/2018

Login to get access

Abstract

To evaluate the association between vascular risk factors and cognitive impairment among older African American (AA) adults in a primary care clinic. Participants included 96 AA adults aged 60 years or older who were evaluated for global and domain-specific cognition. Participants were interviewed using the Computerized Assessment of Memory and Cognitive Impairment (CAMCI). The relationship between CAMCI cognitive domain scores and vascular risk factors were examined using hierarchical regression models. Patients who smoked, those with higher SBP/DBP values had lower accuracy rates on CAMCI cognitive domains (attention, executive, memory).Those with higher BMI had better attention scores. Patients with higher HbA1C values had worse verbal memory. Patients with higher blood pressure were significantly faster in responding to tasks in the executive domain. Primary care providers working with older AA adults with these VRFs could implement cognitive screening earlier into their practice to reduce barriers of seeking treatment.
Literature
1.
2.
3.
Luchsinger JA, Reitz C, Patel B, Tang MX, Manly JJ, Mayeux R. Relation of diabetes to mild cognitive impairment. Arch Neurol. 2007;64(4):570–5.CrossRefPubMed
4.
Tang MX, Cross P, Andrews H, Jacobs DM, Small S, Bell K, et al. Incidence of AD in African–Americans, caribbean hispanics, and caucasians in northern Manhattan. Neurology. 2001;56(1):49–56.CrossRefPubMed
5.
Ferdinand KC, Townsend RR. Hypertension in the US Black population: risk factors, complications, and potential impact of central aortic pressure on effective treatment. Cardiovasc Drugs Ther. 2012;26(2):157–65.CrossRefPubMed
6.
Kwolek CJ, Clagett GP. Changing demographics in patients with vascular disease. J Vasc Surg. 2009;49(2):528–31.CrossRefPubMed
7.
Peila R, Rodriguez BL, Launer LJ, Honolulu-Asia Aging Study. Type 2 diabetes, APOE gene and the risk for dementia and related pathologies: the Honolulu-Asia aging study. Diabetes. 2002;51(4):1256–62.CrossRefPubMed
8.
Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia. Lancet. 2000;356(9242):1627–31.CrossRefPubMed
9.
Skoog I, Nilsson L, Persson G, Lernfelt B, Landahl S, Palmertz B, et al. 15-year longitudinal study of blood pressure and dementia. Lancet. 1996;347(9009):1141–5.CrossRefPubMed
10.
Ott A, Breteler MM, de Bruyne MC, van Harskamp F, Grobbee DE, Hofman A. Atrial fibrillation and dementia in a population-based study. The Rotterdam Study. Stroke. 1997;28(2):316–21.CrossRefPubMed
11.
Merchant C, Tang MX, Albert S, Manly J, Stern Y, Mayeux R. The influence of smoking on the risk of Alzheimer’s disease. Neurology. 1999;52(7):1408–12.CrossRefPubMed
12.
Ott A, Slooter A, Hofman A, van Harskamp F, Witteman J, Van Broeckhoven C, et al. Smoking and risk of dementia and Alzheimer’s disease in a population-based cohort study: the Rotterdam Study. Lancet. 1998;351(9119):1840–3.CrossRefPubMed
13.
Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kåreholt I, Winblad B, et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol. 2005;62(10):1556–60.CrossRefPubMed
14.
Breteler MM. Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective. Neurobiol Aging. 2000;21(2):153–60.CrossRefPubMed
15.
Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011;42(9):2672–713.CrossRefPubMedPubMedCentral
16.
Liu H, Gao S, Hall KS, Unverzagt FW, Lane KA, Callahan CM, et al. Optimal blood pressure for cognitive function: findings from an elderly African–American Cohort Study. J Am Geriatr Soc. 2013;61(6):875–81.CrossRefPubMedPubMedCentral
17.
Carmasin JS, Mast BT, Allaire JC, Whitfield KE. Vascular risk factors, depression, and cognitive change among African American older adults. Int J Geriatr Psychiatry. 2014;29(3):291–8.CrossRefPubMed
18.
Tsivgoulis G, Alexandrov AV, Wadley VG, Unverzagt FW, Go RC, Moy CS, et al. Association of higher diastolic blood pressure levels with cognitive impairment. Neurology. 2009;73(8):589–95.CrossRefPubMedPubMedCentral
19.
Kamat SM, Kamat AS, Grossberg GT. Dementia risk prediction: are we there yet? Clin Geriatr Med. 2010;26(1):113–23.CrossRefPubMed
20.
Welsh-Bohmer KA, Breitner JC, Hayden KM, Lyketsos C, Zandi PP, Tschanz JT, et al. Modifying dementia risk and trajectories of cognitive decline in aging: the Cache County Memory Study. Alzheimer’s Dementia. 2006;2(3):257–60.CrossRefPubMed
21.
22.
International Agency for Research on Cancer. Reversal of risk after quitting smoking. 2007.
23.
Team RC. R: a language and environment for statistical. Vienna: Computing.R Foundation for Statistical Computing; 2013. p. 2014.
24.
Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimers Dement. 2011;7(2):208–44.CrossRef
25.
Sando SB, Melquist S, Cannon A, Hutton M, Sletvold O, Saltvedt I, et al. Risk-reducing effect of education in Alzheimer’s disease. Int J Geriatr Psychiatry. 2008;23(11):1156–62.CrossRefPubMed
26.
Barnes LL, Wilson RS, Li Y, Gilley DW, Bennett DA, Evans DA. Change in cognitive function in Alzheimer’s disease in African–American and white persons. Neuroepidemiology. 2006;26(1):16–22.CrossRefPubMed
27.
Ritchie K, Lovestone S. The dementias. The Lancet. 2002;360(9347):1759–66.CrossRef
28.
29.
Prince M, Albanese E, Guerchet M, Prina M. World Alzheimer Report 2014. Dementia and risk reduction: an analysis of protective and modifiable factors. Londen: Alzheimers Disease International. 2014.
30.
Plassman BL, Williams JW, Burke JR, Holsinger T, Benjamin S. Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life. Ann Intern Med. 2010;153(3):182–93.CrossRefPubMed
31.
Baumgart M, Snyder HM, Carrillo MC, Fazio S, Kim H, Johns H. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimer Dement. 2015;11(6):718–26.CrossRef
32.
Power MC, Weuve J, Gagne JJ, McQueen MB, Viswanathan A, Blacker D. The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis. Epidemiology. 2011;22(5):646–59.CrossRefPubMedPubMedCentral
33.
Guan J, Huang C, Li Y, Wan C, You C, Wang Z, et al. No association between hypertension and risk for Alzheimer’s disease: a meta-analysis of longitudinal studies. J Alzheimer Dis. 2011;27(4):799–807.
34.
Corrada M, Hayden KM, Bullain SS, Paganini-Hill A, DeMoss J, Aguirre C, et al. Age of onset of hypertension and risk of dementia in the oldest-old: the 90 study. Alzheimer Dement. 2014;10(4):p. 501.CrossRef
35.
Wotton CJ, Goldacre MJ. Age at obesity and association with subsequent dementia: record linkage study. Postgrad Med J. 2014;90(1068):547–51.CrossRefPubMed
36.
Qizilbash N, Gregson J, Johnson ME, Pearce N, Douglas I, Wing K, et al. BMI and risk of dementia in two million people over two decades: a retrospective cohort study. Lancet Diabetes & amp Endocrinol. 2015;3(6):431–6.CrossRef
37.
Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: a meta-analysis of prospective observational studies. J Diabetes Investig. 2013;4(6):640–50.CrossRefPubMedPubMedCentral
38.
Savva GM, Stephan BC, Alzheimer’s Society Vascular Dementia Systematic Review Group. Epidemiological studies of the effect of stroke on incident dementia: a systematic review. Stroke. 2010;41(1):e41–6.CrossRefPubMed
39.
Johnson KC, Margolis KL, Espeland MA, Colenda CC, Fillit H, Manson JE, Masaki KH, Mouton CP, Prineas R, Robinson JG, Wassertheil-Smoller S. A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women’s Health Initiative Memory Study. J Am Geriatr Soc. 2008;56:1449–58.CrossRefPubMed
40.
Vinyoles E, De la Figuera M, Gonzalez-Segura D. Cognitive function and blood pressure control in hypertensive patients over 60 years of age: COGNIPRES study. Curr Med Res Opin. 2008;24(12):3331–9.CrossRefPubMed
Metadata
Title
Cognitive Function and Vascular Risk Factors Among Older African American Adults
Authors
Ishan C. Williams
Moon Ho Park
Siny Tsang
Scott A. Sperling
Carol Manning
Publication date
01-06-2018
Publisher
Springer US
Published in
Journal of Immigrant and Minority Health / Issue 3/2018
Print ISSN: 1557-1912
Electronic ISSN: 1557-1920
DOI
https://doi.org/10.1007/s10903-017-0583-7

Other articles of this Issue 3/2018

Journal of Immigrant and Minority Health 3/2018 Go to the issue

Original Paper

Acculturation Versus Cultural Retention: The Interactive Impact of Acculturation and Co-ethnic Ties on Substance Use Among Chinese Students in the United States

Original Paper

Psychopathology and Associated Risk Factors Among Forcibly Displaced Syrian Children and Adolescents

Original Paper

Colorectal Cancer Screening Compliance among Asian and Pacific Islander Americans

Original Paper

Changing Places, Changing Plates? A Binational Comparison of Barriers and Facilitators to Healthful Eating Among Central American Communities

Original Paper

The Influence of Hispanic Ethnicity and Nativity Status on 2009 H1N1 Pandemic Vaccination Uptake in the United States

Original Paper

Exploring Predictors of Information Use to Self-Manage Blood Pressure in Midwestern African American Women with Hypertension