Top

Published in:

01-12-2024 | CO2 Laser | Original Article

Advantages of the co₂ laser use in the rare condition of nasal mucosa squamous cell carcinoma surgery in dogs—a clinical prospective study

Authors: L. Miguel Carreira, P. Azevedo

Published in: Lasers in Medical Science | Issue 1/2024

Abstract

Nasal mucosa tumors are an uncommon process and very dificult to work on with surgery. Radiotherapy associated or not with chemotherapy is the standard method to treat the disease. However, its access it is in the majority of the case not possible, making the surgery the best choice to try to achieve the patient's control. The anatomy of the region makes the complete surgical resection very difficult to achieve using the common and conventional blade scalpel surgery. The study features the advantages of using a CO₂ laser to perform nasal mucosa carcinoma surgery in 6 dogs (N = 6). For the work we used an Aesculigth CO₂ surgical laser model -Vetscalpel®, with the settings of 12Watts in a Superpulse mode, and a 0.25–0.4 mm focus to dissect the nasal mucosa, and a 1.5 mm focus for vaporization of the area. All the masses were histopathologically characterized as squamous cells carcinoma. The CO₂ surgical laser allow us to work in a bloodless region promoting a more accurate dissection of the nasal mucosa sparing therefore the underlying and adjacent tissues and being less invasive. Also, it was possible to do the vaporization of the entire surgical area interviened. None of the patients presented relapse of clinical signs. Only 2 individuals were alive at the end of the study, presenting a survival rate of 420 and 514 days, which is in the same line of literature results of the treatment with radiotherapy combined with chemotherapy wich shows a median of 474–580 days. The study demonstrates successful outcomes with CO₂ laser surgery in treating nasal mucosa SCC in dogs, with patients experiencing improved survival rates compared to traditional treatment methods. This highlights the efficacy and potential of CO₂ laser surgery as a valuable tool in managing aggressive nasal tumors in veterinary oncology.

Madewell BR, Priester WA, Gillete EL et al (1976) Neoplasms of the nasal passages and paranasal sinuses in domesticated animals as reported by 13 veterinary colleges. Am J Vet Res 37(7):851–856PubMed

Brodey RS (1970) Canine and feline neoplasia. Adv Vet Sci Comp Med 14:309–354PubMed

Patnaik AK (1989) Canine sinonasal neoplasms: clinicopathological study of 285 Cases. J Am Anim Hosp Assoc 25:103–114

LaDue TA, Dodge R, Page RL et al (1999) Factors influencing survival after radiotherapy of nasal tumors in 130 dogs. Vet Radiol Ultrasound 40(3):312–317PubMedCrossRef

MacEwen EG, Withrow SJ, Patnaik AK (1977) Nasal tumors in the dog: retrospective evaluation of diagnosis, prognosis, and treatment. J Am Vet Med Assoc 170(1):45–48PubMed

Adams WM, Kleiter MM, Thrall DE et al (2009) Prognostic significance of tumor histology and computed tomographic staging for radiation treatment response of canine nasal tumors. Vet Radiol Ultrasound 50(3):330–335PubMedCrossRef

Yoon JH, Feeney DA, Jessen CR et al (2008) External-beam Co-60 radiotherapy for canine nasal tumors: a comparison of survival by treatment protocol. Res Vet Sci 84(1):140–149PubMedCrossRef

Henry CJ, Brewer WG Jr, Tyler JW et al (1998) Survival in dogs with nasal adenocarcinoma: 64 cases (1981–1995). J Vet Intern Med 12(6):436–439PubMedCrossRef

Kleiter M, Malarkey DE, Ruslander DE et al (2004) Expression of cyclooxygenase-2 in canine epithelial nasal tumors. Vet Radiol Ultrasound 45(3):255–260PubMedCrossRef

10.

Rassnick KM, Goldkamp CE, Erb HN et al (2006) Evaluation of factors associated with survival in dogs with untreated nasal carcinomas: 139 cases (1993–2003). J Am Vet Med Assoc 229(3):401–406PubMedCrossRef

11.

Mellanby RJ, Stevenon RK, Herrtage ME et al (2002) Long-term outcome of 56 dogs with nasal tumours treated with four doses of radiation at intervals of seven days. Vet Rec 151(9):253–257PubMedCrossRef

12.

Morris JS, Dunn KJ, Dobson JM et al (1996) Radiological assessment of severity of canine nasal tumours and relationship with survival. J Small Anim Pract 37(1):1–6PubMedCrossRef

13.

Avner A, Dobson JM, Sales JI et al (2008) Retrospective review of 50 canine nasal tumours evaluated by low-field magnetic resonance imaging. J Small Anim Pract 49:233–239PubMedCrossRef

14.

Reif JS, Bruns C, Lower KS (1998) Cancer of the nasal cavity and paranasal sinuses and exposure to environmental tobacco smoke in pet dogs. Am J Epidemiol 147(5):488–492PubMedCrossRef

15.

Tasker S, Knottenbelt CM, Munro EA et al (1999) Aetiology and diagnosis of persistent nasal disease in the dog: a retrospective study of 42 cases. J Small Anim Pract 40(10):473–478PubMedCrossRef

16.

Bukowski JA, Wartenberg D, Goldschmidt M (1998) Environmental causes for sinonasal cancers in pet dogs, and their usefulness as sentinels of indoor cancer risk. J Toxicol Environ Health A 54(7):579–591PubMedCrossRef

17.

Laing EJ, Binnington AG (1988) Surgical therapy of canine nasal tumors: a retrospective study (1982–1986). Can Vet J 29(10):809–813PubMedPubMedCentral

18.

Holmberg DL, Fries C, Cockshutt J et al (1989) Ventral rhinotomy in the dog and cat. Vet Surg 18(6):446–449PubMedCrossRef

19.

Miguel CL, Azevedo P (2016) Comparison of the Influence of CO2-LASER and Scalpel Skin Incisions on the Surgical Wound Healing Process. ARC J Anesthesiol 1(3):1–8. https://doi.org/10.20431/2455-9792.0103001CrossRef

20.

Lent SE, Hawkins EC (1992) Evaluation of rhinoscopy and rhinoscopy-assisted mucosal biopsy in diagnosis of nasal disease in dogs: 119 cases (1985–1989). J Am Vet Med Assoc 201(9):1425–1429PubMedCrossRef

21.

Gamblin RM, Sagartz JE, Couto CG (1997) Overexpression of p53 tumor suppressor protein in spontaneously arising neoplasms of dogs. Am J Vet Res 58(8):857–863PubMedCrossRef

22.

Borzacchiello G, Paciello O, Papparella S (2004) Expression of cyclooxygenase-1 and -2 in canine nasal carcinomas. J Comp Pathol 131(1):70–76PubMedCrossRef

23.

Impellizeri JA, Esplin DG (2008) Expression of cyclooxygenase-2 in canine nasal carcinomas. Vet J 176(3):408–410PubMedCrossRef

24.

Lefebvre J, Kuehn NF, Wortinger A (2005) Computed tomography as an aid in the diagnosis of chronic nasal disease in dogs. J Small Anim Pract 46(6):280–285PubMedCrossRef

25.

Saunders JH, van Bree H, Gielen I et al (2003) Diagnostic value of computed tomography in dogs with chronic nasal disease. Vet Radiol Ultrasound 44(4):409–413PubMedCrossRef

26.

Dhaliwal RS, Kitchell BE, Losonsky JM et al (2004) Subjective evaluation of computed tomography and magnetic resonance imaging for detecting intracalvarial changes in canine nasal neoplasia. Intern J Appl Res Vet Med 2(3):201–208

27.

Drees R, Forrest LJ, Chappell R (2009) Comparison of computed tomography and magnetic resonance imaging for the evaluation of canine intranasal neoplasia. J Small Anim Pract 50(7):334–340PubMedPubMedCentralCrossRef

28.

Windsor RC, Johnson LR, Herrgesell EJ et al (2004) Idiopathic lymphoplasmacytic rhinitis in dogs: 37 cases (1997–2002). J Am Vet Med Assoc 224(12):1952–1957PubMedCrossRef

29.

Strasser JL, Hawkins EC (2005) Clinical features of epistaxis in dogs: a retrospective study of 35 cases (1999–2002). J Am Anim Hosp Assoc 41(3):179–184PubMedCrossRef

30.

Hunley DW, Mauldin GN, Shiomitsu K et al (2010) Clinical outcome in dogs with nasal tumors treated with intensity-modulated radiation therapy. Can Vet J 51(3):293–300PubMedPubMedCentral

31.

Northrup NC, Etuw SM, Ruslander DM et al (2001) Retrospective study of orthovoltage radiation therapy for nasal tumors in 42 dogs. J Vet Intern Med 15(3):183–189PubMedCrossRef

32.

Gutierrez AN, Deveau M, Forrest LJ et al (2007) Radiobiological and treatment planning study of a simultaneously integrated boost for canine nasal tumors using helical tomotherapy. Vet Radiol Ultrasound 48(6):594–602PubMedCrossRef

33.

McEntee MC, Page RL, Heidner GL et al (1991) A retrospective study of 27 dogs with intranasal neoplasms treated with cobalt radiation. Vet Radiol 32(3):135–139CrossRef

34.

Adams WM, Bjorling DE, McAnulty JE et al (2005) Outcome of accelerated radiotherapy alone or accelerated radiotherapy followed by exenteration of the nasal cavity in dogs with intranasal neoplasia: 53 cases (1990–2002). J Am Vet Med Assoc 227(6):936–941PubMedCrossRef

35.

Lana SE, Dernell WS, Lafferty MH et al (2004) Use of radiation and a slow-release cisplatin formulation for treatment of canine nasal tumors. Vet Radiol Ultrasound 45(6):577–581PubMedCrossRef

36.

Gieger T, Rassnick K, Siegel S et al (2008) Palliation of clinical signs in 48 dogs with nasal carcinomas treated with coarse-fraction radiation therapy. J Am Anim Hosp Assoc 44(3):116–123PubMedCrossRef

37.

Morris JS, Dunn KJ, Dobson JM et al (1994) Effects of radiotherapy alone and surgery and radiotherapy on survival of dogs with nasal tumours. J Small Anim Pract 35:573–576CrossRef

38.

Correa SS, Mauldin GN, Mauldin GE et al (2003) Efficacy of cobalt-60 radiation therapy for the treatment of nasal cavity nonkeratinizing squamous cell carcinoma in the dog. J Am Anim Hosp Assoc 39(1):86–89PubMedCrossRef

39.

Adams WM, Withrow SJ, Walshaw R et al (1987) Radiotherapy of malignant nasal tumors in 67 dogs. J Am Vet Med Assoc 191(3):311–315PubMed

40.

Lana SE, Dernell WS, LaRue SM et al (1997) Slow release cisplatin combined with radiation for the treatment of canine nasal tumors. Vet Radiol Ultrasound 38(6):474–478PubMedCrossRef

41.

Buchholz J, Hagen R, Leo C et al (2009) 3D conformal radiation therapy for palliative treatment of canine nasal tumors. Vet Radiol Ultrasound 50(6):679–683PubMedCrossRef

42.

Sfiligoi G, Theon AP, Kent MS (2007) Response of nineteen cats with nasal lymphoma to radiation therapy and chemotherapy. Vet Radiol Ultrasound 48(4):388–393PubMedCrossRef

43.

Evans SM, Goldschmidt M, McKee LJ et al (1989) Prognostic factors and survival after radiotherapy for intranasal neoplasms in dogs: 70 cases (1974–1985). J Am Vet Med Assoc 194(10):1460–1463PubMed

44.

Testa D, Motta S, Massimilla EA, Tafuri D, Russo D, Russo A, Landolfo PG, Mesolella M, Motta G (2015) Cavernous hemangioma of rhinopharynx: our experience and review of literature. Open Med 10(1):523–528. https://doi.org/10.1515/med-2015-0089CrossRef

45.

Deppe H, Horch HH (2007) Current Status of LASER Application in Oral and Cranio-Maxillofacial Surgery. Med Laser Appl 22(1):39–42CrossRef

46.

Strauss R (1997) Laser management of discrete lesions. In: Catone G, Alling C (eds) Laser applications in oral and maxillofacial surgery (Chapter 14, pp 257). WB Saunders, Philadelphia

Title: Advantages of the co2 laser use in the rare condition of nasal mucosa squamous cell carcinoma surgery in dogs—a clinical prospective study
Authors: L. Miguel Carreira
P. Azevedo
Publication date: 01-12-2024
Publisher: Springer London
Keyword: CO2 Laser
Published in: Lasers in Medical Science / Issue 1/2024
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-024-04059-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Advantages of the co₂ laser use in the rare condition of nasal mucosa squamous cell carcinoma surgery in dogs—a clinical prospective study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2024

Photobiomodulation increases brain metabolic activity through a combination of 810 and 660 wavelengths: a comparative study in male and female rats

Complication rates and safety of pulsed dye laser treatment for port-wine stain: a systematic review and meta-analysis

Laser treatment for adverse reactions to injectable facial filling: a systematic review

Advances in far-infrared research: therapeutic mechanisms of disease and application in cancer detection

Long-term effects of photobiomodulation therapy on blood pressure in obese rats induced by a high-fat diet

Enhancing nerve regeneration in infraorbital nerve injury rat model: effects of vitamin B complex and photobiomodulation