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Open Access 01-12-2012 | Research article

Co-prescription of medication for bipolar disorder and diabetes mellitus: a nationwide population-based study with focus on gender differences

Authors: Gjertrud Svendal, Ole Bernt Fasmer, Anders Engeland, Michael Berk, Anders Lund

Published in: BMC Medicine | Issue 1/2012

Abstract

Background

Studies have shown a correlation between bipolar disorder and diabetes mellitus. It is unclear if this correlation is a part of common pathophysiological pathways, or if medication for bipolar disorder has negative effects on blood sugar regulation.

Methods

The Norwegian prescription database was analyzed. Prescriptions for lithium, lamotrigine, carbamazepine and valproate were used as proxies for bipolar disorder. Prescriptions for insulin and oral anti-diabetic agents were used as proxies for diabetes mellitus. We explored the association between medication for bipolar disorder and diabetes medication by logistic regression

Results

We found a strong association between concomitant use of medication to treat diabetes mellitus and mood stabilizers for the treatment of bipolar disorder. Females had a 30% higher risk compared to men of being treated for both disorders. Persons using oral anti-diabetic agents had higher odds of receiving valproate than either lithium or lamotrigine. Use of insulin as monotherapy seemed to have lower odds than oral anti-diabetic agents of co-prescription of mood stabilizers, compared to the general population.

Conclusions

This study showed a strong association between the use of mood stabilizers and anti-diabetic agents. The association was stronger among women than men.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/10/148/prepub

Title: Co-prescription of medication for bipolar disorder and diabetes mellitus: a nationwide population-based study with focus on gender differences
Authors: Gjertrud Svendal
Ole Bernt Fasmer
Anders Engeland
Michael Berk
Anders Lund
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2012
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/1741-7015-10-148

At a glance: The STEP trials

Springer Medicine

Co-prescription of medication for bipolar disorder and diabetes mellitus: a nationwide population-based study with focus on gender differences

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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