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Open Access 01-12-2022 | Research

Clusters of preterm live births and respiratory distress syndrome-associated neonatal deaths: spatial distribution and cooccurrence patterns

Authors: Ana Sílvia Scavacini Marinonio, Daniela Testoni Costa-Nobre, Milton Harumi Miyoshi, Rita de Cassia Xavier Balda, Kelsy Catherina Nema Areco, Tulio Konstantyner, Mandira Daripa Kawakami, Adriana Sanudo, Paulo Bandiera-Paiva, Rosa Maria Vieira de Freitas, Lilian Cristina Correia Morais, Mônica La Porte Teixeira, Bernadette Cunha Waldvogel, Maria Fernanda Branco de Almeida, Ruth Guinsburg, Carlos Roberto Veiga Kiffer

Published in: BMC Public Health | Issue 1/2022

Abstract

Background

Prematurity and respiratory distress syndrome (RDS) are strongly associated. RDS continues to be an important contributor to neonatal mortality in low- and middle-income countries. This study aimed to identify clusters of preterm live births and RDS-associated neonatal deaths, and their cooccurrence pattern in São Paulo State, Brazil, between 2004 and 2015.

Methods

Population-based study of all live births with gestational age ≥ 22 weeks, birthweight ≥ 400 g, without congenital anomalies from mothers living in São Paulo State, Brazil, during 2004–2015. RDS-associated neonatal mortality was defined as deaths < 28 days with ICD-10 codes P22.0 or P28.0. RDS-associated neonatal mortality and preterm live births rates per municipality were submitted to first- and second-order spatial analysis before and after smoothing using local Bayes estimates. Spearman test was applied to identify the correlation pattern between both rates.

Results

Six hundred forty-five thousand two hundred seventy-six preterm live births and 11,078 RDS-associated neonatal deaths in São Paulo State, Brazil, during the study period were analyzed. After smoothing, a non-random spatial distribution of preterm live births rate (I = 0.78; p = 0.001) and RDS-associated neonatal mortality rate (I = 0.73; p = 0.001) was identified. LISA maps confirmed clusters for both, with a negative correlation (r = -0.24; p = 0.0000). Clusters of high RDS-associated neonatal mortality rates overlapping with clusters of low preterm live births rates were detected.

Conclusions

Asymmetric cluster distribution of preterm live births and RDS-associated neonatal deaths may be helpful to indicate areas for perinatal healthcare improvement.

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Title: Clusters of preterm live births and respiratory distress syndrome-associated neonatal deaths: spatial distribution and cooccurrence patterns
Authors: Ana Sílvia Scavacini Marinonio
Daniela Testoni Costa-Nobre
Milton Harumi Miyoshi
Rita de Cassia Xavier Balda
Kelsy Catherina Nema Areco
Tulio Konstantyner
Mandira Daripa Kawakami
Adriana Sanudo
Paulo Bandiera-Paiva
Rosa Maria Vieira de Freitas
Lilian Cristina Correia Morais
Mônica La Porte Teixeira
Bernadette Cunha Waldvogel
Maria Fernanda Branco de Almeida
Ruth Guinsburg
Carlos Roberto Veiga Kiffer
Publication date: 01-12-2022
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2022
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-022-13629-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clusters of preterm live births and respiratory distress syndrome-associated neonatal deaths: spatial distribution and cooccurrence patterns

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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