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Critical Care
Published in: Critical Care 1/2013

01-02-2013 | Letter

Clostridium difficile outcomes difficult to generalize

Authors: Naresh Nagella, Khenj-Jim Lim, Amay Parikh

Published in: Critical Care | Issue 1/2013

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Excerpt

We read with interest the previous issue of Critical Care, in which Zahar and colleagues [1] described Clostridium difficile infection (CDI) in patients during an intensive care unit (ICU) stay. Given some limitations of the authors' study, it is difficult to generalize from the results that CDI detected early will not affect ICU length of stay or mortality. …
Literature
1.
Zahar JR, Schwebel C, Adrie C, Garrouste-Orgeas M, Français A, Vesin A, Nguile-Makao M, Tabah A, Laupland K, Le-Monnier A, Timsit JF, the OUTCOMEREA study group: Outcome of ICU patients with Clostridium difficile infection. Crit Care 2012, 16: R215. 10.1186/cc11852PubMedCentralCrossRefPubMed
2.
Barbut F, Mastrantonio P, Delmée M, Brazier J, Kuijper E, Poxton I, European Study Group on Clostridium difficile (ESGCD): Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterisation of the isolates. Clin Microbiol Infect 2007, 13: 1048-1057. 10.1111/j.1469-0691.2007.01824.xCrossRefPubMed
3.
Katz DA, Lynch ME, Littenberg B: Clinical prediction rules to optimize cytotoxin testing for Clostridium difficile in hospitalized patients with diarrhea. Am J Med 1996, 100: 487-495. 10.1016/S0002-9343(95)00016-XCrossRefPubMed
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Buchan BW, Mackey TL, Daly JA, Alger G, Denys GA, Peterson LR, Kehl SC, Ledeboer NA: Multicenter clinical evaluation of the portrait toxigenic C. difficile assay for detection of toxigenic Clostridium difficile strains in clinical stool specimens. J Clin Microbiol 2012, 50: 3932-3936. 10.1128/JCM.02083-12PubMedCentralCrossRefPubMed
5.
Zar FA, Bakkanagari SR, Moorthi KM, Davis MB: A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 2007, 45: 302-307. 10.1086/519265CrossRefPubMed
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Garrouste Orgeas M, Timsit JF, Soufir L, Tafflet M, Adrie C, Philippart F, Zahar JR, Clec'h C, Goldran-Toledano D, Jamali S, Dumenil AS, Azoulay E, Carlet J, Outcomerea Study Group: Impact of adverse events on outcomes in intensive care unit patients. Crit Care Med 2008, 36: 2041-2047. 10.1097/CCM.0b013e31817b879cCrossRefPubMed
Metadata
Title
Clostridium difficile outcomes difficult to generalize
Authors
Naresh Nagella
Khenj-Jim Lim
Amay Parikh
Publication date
01-02-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11935

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