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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 2/2019

01-02-2019 | Original Article

Clinicopathologic Characteristics and Optimal Surgical Treatment of Duodenal Gastrointestinal Stromal Tumor

Authors: Seung Jae Lee, Ki Byung Song, Young-Joo Lee, Song Cheol Kim, Dae Wook Hwang, Jae Hoon Lee, Sang Hyun Shin, Jae Woo Kwon, Seung Hyun Hwang, Chung Hyeun Ma, Gui Suk Park, Ye Jong Park, Kwang-Min Park

Published in: Journal of Gastrointestinal Surgery | Issue 2/2019

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Abstract

Background

The clinicopathologic characteristics of duodenal gastrointestinal stromal tumor (GIST) were unclear and the optimal surgical procedure for duodenal GIST remains poorly defined. We aimed to analyze clinicopathological characteristics, survival outcomes based on the surgical procedure, and recommend optimal surgical treatment for duodenal GIST.

Methods

From July 2000 to April 2017, 118 patients with localized duodenal GIST underwent curative surgical resection at a single institution. We retrospectively reviewed the clinicopathological characteristics and survival outcomes.

Results

The 5-year overall survival (OS) and disease-free survival (DFS) rates were 94.9 and 79.2%, respectively. On multivariate analysis, the mitotic count was a statistically significant prognostic factor for DFS. Limited resection (LR) was performed in 20 patients with GIST in the first or fourth portion of the duodenum. Both LR and pancreaticoduodenectomy (PD) were performed in 98 patients with GIST in second or third portion of the duodenum. The patients in the LR group had less late complications than in the PD group and no postoperative newly developed diabetes mellitus. The minimally invasive LR (MI-LR) group had a shorter duration of surgery and shorter length of postoperative hospital stay.

Conclusion

LR is a feasible and effective surgical treatment for patients with small-sized and antimesenteric-sided duodenal GIST in terms of late complications and postoperative diabetic complications. MI-LR has better perioperative outcomes than open LR. Therefore, we should consider MI-LR as an optimal surgical treatment for selected patients with duodenal GIST.
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Metadata
Title
Clinicopathologic Characteristics and Optimal Surgical Treatment of Duodenal Gastrointestinal Stromal Tumor
Authors
Seung Jae Lee
Ki Byung Song
Young-Joo Lee
Song Cheol Kim
Dae Wook Hwang
Jae Hoon Lee
Sang Hyun Shin
Jae Woo Kwon
Seung Hyun Hwang
Chung Hyeun Ma
Gui Suk Park
Ye Jong Park
Kwang-Min Park
Publication date
01-02-2019
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 2/2019
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-018-3928-1

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