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01-02-2020 | Review Article

Clinical Utility of Autologous Salvaged Blood: a Review

Authors: Steven M. Frank, Robert A. Sikorski, Gerhardt Konig, Diamantis I. Tsilimigras, Jan Hartmann, Mark A. Popovsky, Timothy M. Pawlik, Jonathan H. Waters

Published in: Journal of Gastrointestinal Surgery | Issue 2/2020

Abstract

Introduction

Autologous salvaged blood, commonly referred to as “cell saver” or “cell salvage” blood, is an important method of blood conservation. Understanding the mechanism of action and summarizing the existing evidence regarding the safety, efficiency, and the relative costs of cell salvage may help educate clinicians on how and when to best utilize autotransfusion.

Methods

This review focuses on issues concerning the quality of red blood cells (RBC), efficiency, and the cost effectiveness relative to autotransfusion. The key considerations of safe use and clinical applicability are described along with the challenges for wider dissemination.

Results

Cell salvage can reduce requirements for allogeneic transfusions, along with the associated risks and costs. Autologous salvaged RBCs provide high-quality transfusion, since the cells have not been subjected to the adverse effects of storage as occurs with banked blood. The risks for RBC alloimmunization and transfusion-related infectious diseases are also avoided. With a careful selection of cases, salvaged blood can be more cost effective than donor blood. Cell salvage may have a role in cardiac, major vascular, orthopedic, transplant, and trauma surgeries. However, there remain theoretical safety concerns in cases with bacterial contamination or in cancer surgery.

Conclusion

In addition to other methods of blood conservation used in patient blood management programs, autologous salvaged blood adds value and is cost effective for appropriate surgical cases. Evidence suggests that autologous salvaged blood may be of higher quality and confer a cost reduction compared with the allogeneic banked blood, when used appropriately.

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Title: Clinical Utility of Autologous Salvaged Blood: a Review
Authors: Steven M. Frank
Robert A. Sikorski
Gerhardt Konig
Diamantis I. Tsilimigras
Jan Hartmann
Mark A. Popovsky
Timothy M. Pawlik
Jonathan H. Waters
Publication date: 01-02-2020
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 2/2020
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-019-04374-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical Utility of Autologous Salvaged Blood: a Review

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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