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Trials
Published in: Trials 1/2009

Open Access 01-12-2009 | Study protocol

Clinical trial to assess the effect of physical exercise on endothelial function and insulin resistance in pregnant women

Authors: Robinson Ramírez-Vélez, Ana C Aguilar, Mildrey Mosquera, Ronald G Garcia, Laura M Reyes, Patricio López-Jaramillo

Published in: Trials | Issue 1/2009

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Abstract

Background

Preeclampsia (PE) is a common maternal disease that complicates 5 to 10% of pregnancies and remains as the major cause of maternal and neonatal mortality. Cost-effective interventions aimed at preventing the development of preeclampsia are urgently needed. However, the pathogenesis of PE is not well known. Multiple mechanisms such as oxidative stress, endothelial dysfunction and insulin resistance may contribute to its development. Regular aerobic exercise recovers endothelial function; improves insulin resistance and decreases oxidative stress. Therefore the purpose of this clinical trial is to determine the effect of regular aerobic exercise on endothelial function, on insulin resistance and on pregnancy outcome.

Methods and design

64 pregnant women will be included in a blind, randomized clinical trial, and parallel assignment. The exercise group will do regular aerobic physical exercise: walking (10 minutes), aerobic exercise (30 minutes), stretching (10 minutes) and relaxation exercise (10 minutes) in three sessions per week. Control group will do the activities of daily living (bathing, dressing, eating, and walking) without counselling from a physical therapist.

Trial registration

NCT00741312.
Appendix
Available only for authorised users
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Metadata
Title
Clinical trial to assess the effect of physical exercise on endothelial function and insulin resistance in pregnant women
Authors
Robinson Ramírez-Vélez
Ana C Aguilar
Mildrey Mosquera
Ronald G Garcia
Laura M Reyes
Patricio López-Jaramillo
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Trials / Issue 1/2009
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-10-104

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