Skip to main content
Top
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Commentary

Clinical study replicability and the pursuit of excellence

Authors: Michael J. Lanspa, Eliotte L. Hirshberg, Russell R. Miller III, Alan H. Morris

Published in: Critical Care | Issue 1/2015

Login to get access

Abstract

Comparisons of processes of care are common in critical care research. Often, these processes are neither explicit nor replicable and this can result in seemingly irreconcilable results. Here, we briefly review the article by Taniguchi and colleagues, who studied liberation from mechanical ventilation by using either a computerized weaning protocol or one driven by respiratory therapists. We discuss the implications of explicit protocols increasing replicability in clinical research.
Literature
1.
go back to reference Taniguchi C, Victor ES, Pieri T, Henn R, Santana C, Giovanetti E, et al. SmartCare™ versus respiratory physiotherapy driven manual weaning for critically ill adult patients: a randomized and controlled trial. Crit Care. 2015;19:246.CrossRef Taniguchi C, Victor ES, Pieri T, Henn R, Santana C, Giovanetti E, et al. SmartCare™ versus respiratory physiotherapy driven manual weaning for critically ill adult patients: a randomized and controlled trial. Crit Care. 2015;19:246.CrossRef
2.
go back to reference Breen D, Karabinis A, Malbrain M, Morais R, Albrecht S, Jarnvig IL, et al. Decreased duration of mechanical ventilation when comparing analgesia-based sedation using remifentanil with standard hypnotic-based sedation for up to 10 days in intensive care unit patients: a randomised trial [ISRCTN47583497]. Crit Care. 2005;9:R200–10.CrossRef Breen D, Karabinis A, Malbrain M, Morais R, Albrecht S, Jarnvig IL, et al. Decreased duration of mechanical ventilation when comparing analgesia-based sedation using remifentanil with standard hypnotic-based sedation for up to 10 days in intensive care unit patients: a randomised trial [ISRCTN47583497]. Crit Care. 2005;9:R200–10.CrossRef
3.
go back to reference Kress JP, Pohlman AS, O’Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342:1471–7.CrossRef Kress JP, Pohlman AS, O’Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342:1471–7.CrossRef
4.
go back to reference Klompas M, Kleinman KP, Karcz A. Variability in mean duration of mechanical ventilation among community hospitals. Infect Control Hosp Epidemiol. 2012;33:635–7.CrossRef Klompas M, Kleinman KP, Karcz A. Variability in mean duration of mechanical ventilation among community hospitals. Infect Control Hosp Epidemiol. 2012;33:635–7.CrossRef
5.
go back to reference Thompson BT, Schoenfeld D. Usual care as the control group in clinical trials of nonpharmacologic interventions. Proc Am Thorac Soc. 2007;4:577–82.CrossRef Thompson BT, Schoenfeld D. Usual care as the control group in clinical trials of nonpharmacologic interventions. Proc Am Thorac Soc. 2007;4:577–82.CrossRef
6.
go back to reference Needham DM, Colantuoni E, Mendez-Tellez PA, Dinglas VD, Sevransky JE, Dennison Himmelfarb CR, et al. Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study. BMJ. 2012;344, e2124.CrossRef Needham DM, Colantuoni E, Mendez-Tellez PA, Dinglas VD, Sevransky JE, Dennison Himmelfarb CR, et al. Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study. BMJ. 2012;344, e2124.CrossRef
7.
go back to reference Burns KE, Lellouche F, Nisenbaum R, Lessard MR, Friedrich JO. Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults. Cochrane Database Syst Rev. 2014;9, CD008638. Burns KE, Lellouche F, Nisenbaum R, Lessard MR, Friedrich JO. Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults. Cochrane Database Syst Rev. 2014;9, CD008638.
Metadata
Title
Clinical study replicability and the pursuit of excellence
Authors
Michael J. Lanspa
Eliotte L. Hirshberg
Russell R. Miller III
Alan H. Morris
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-1019-1

Other articles of this Issue 1/2015

Critical Care 1/2015 Go to the issue