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Critical Care
Published in: Critical Care 4/2002

01-08-2002 | Review

Clinical review: Use of vancomycin in haemodialysis patients

Authors: Vincent Launay-Vacher, Hassane Izzedine, Lucile Mercadal, Gilbert Deray

Published in: Critical Care | Issue 4/2002

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Abstract

Following intravenous administration, vancomycin is poorly metabolized and is mainly excreted unchanged in urine. Total body clearance is thus dependent on the kidney, and is correlated with glomerular filtration rate and creatinine clearance. Accumulation of vancomycin in patients with renal insufficiency may therefore occur, and this may lead to toxic side effects if dosage is not modified according to the degree of renal failure. Furthermore, vancomycin easily diffuses through dialysis membranes. The aim of the present review is to establish guidelines for handling this drug in such patients. We indicate how and when plasma concentrations of vancomycin should be determined in dialysis patients.
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Metadata
Title
Clinical review: Use of vancomycin in haemodialysis patients
Authors
Vincent Launay-Vacher
Hassane Izzedine
Lucile Mercadal
Gilbert Deray
Publication date
01-08-2002
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2002
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc1516

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