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Clinical Oral Investigations

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01-03-2017 | Original Article

Clinical relevance of the utilization of vital Lugol’s iodine staining in detection and diagnosis of oral cancer and dysplasia

Authors: Imad Elimairi, Mehmet Ali Altay, Omer Abdoun, Amr Elimairi, Sinan Tozoglu, Dale A. Baur, Faisal Quereshy

Published in: Clinical Oral Investigations | Issue 2/2017

Abstract

Objectives

The aim of this study is to assess the clinical relevance of the utilization of vital Lugol’s iodine staining in detection of oral cancer and dysplastic lesions as well as demarcation of the extent of these lesions.

Materials and methods

A prospective, cross-sectional, hospital-based study was performed in Khartoum Teaching Dental Hospital, Sudan. Suspicious oral epithelial lesions indicating incisional biopsy were stained with 10 % Lugol’s iodine solution and were clinically designated as “negative” for dysplasia or neoplasia when no unstained lesion (USL) area was observed, or as “positive” when a USL area is observed. Incisional biopsies involving both the unstained portion and the stained portion were obtained and histologically evaluated for definitive diagnosis.

Results

Forty-five biopsies were obtained from 28 patients. Histopathological examination of the specimens confirmed some degree of dysplasia or neoplasia in all clinically positive specimens with oral squamous cell carcinoma (OSCC) being the most common definitive diagnosis (17 patients, 60.7 %). Clinical relevance level of vital Lugol’s iodine staining in detecting oral cancer and dysplasia was found to be 90.9 % (SE = 0.05, P = 0.05).

Conclusion

The findings of this study showed that Lugol’s iodine is an easy, safe, and effective method of visualizing oral epithelial lesions and differentiating epithelial carcinoma and dysplasia from other benign mucosal lesions. Despite certain limitations, its use is of great value in detection and diagnosis of oral cancer and dysplasia.

Clinical relevance

Lugol’s iodine staining can effectively be used in detection of the dysplastic and malignant superficial lesions of the oral epithelium.

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Title: Clinical relevance of the utilization of vital Lugol’s iodine staining in detection and diagnosis of oral cancer and dysplasia
Authors: Imad Elimairi
Mehmet Ali Altay
Omer Abdoun
Amr Elimairi
Sinan Tozoglu
Dale A. Baur
Faisal Quereshy
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 2/2017
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-016-1925-x

At a glance: The STEP trials

Springer Medicine

Clinical relevance of the utilization of vital Lugol’s iodine staining in detection and diagnosis of oral cancer and dysplasia

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

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