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Open Access 01-12-2014 | Review

Clinical potentials of human pluripotent stem cells in lung diseases

Authors: Yuan Quan, Dachun Wang

Published in: Clinical and Translational Medicine | Issue 1/2014

Abstract

Lung possesses very limited regenerative capacity. Failure to maintain homeostasis of lung epithelial cell populations has been implicated in the development of many life-threatening pulmonary diseases leading to substantial morbidity and mortality worldwide, and currently there is no known cure for these end-stage pulmonary diseases. Embryonic stem cells (ESCs) and somatic cell-derived induced pluripotent stem cells (iPSCs) possess unlimited self-renewal capacity and great potential to differentiate to various cell types of three embryonic germ layers (ectodermal, mesodermal, and endodermal). Therapeutic use of human ESC/iPSC-derived lung progenitor cells for regeneration of injured or diseased lungs will have an enormous clinical impact. This article provides an overview of recent advances in research on pluripotent stem cells in lung tissue regeneration and discusses technical challenges that must be overcome for their clinical applications in the future.

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Title: Clinical potentials of human pluripotent stem cells in lung diseases
Authors: Yuan Quan
Dachun Wang
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: Clinical and Translational Medicine / Issue 1/2014
Electronic ISSN: 2001-1326
DOI: https://doi.org/10.1186/2001-1326-3-15

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical potentials of human pluripotent stem cells in lung diseases

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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