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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2016

Open Access 01-12-2016 | Review

Clinical outcome measures in juvenile idiopathic arthritis

Authors: Alessandro Consolaro, Gabriella Giancane, Benedetta Schiappapietra, Sergio Davì, Serena Calandra, Stefano Lanni, Angelo Ravelli

Published in: Pediatric Rheumatology | Issue 1/2016

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Abstract

Juvenile idiopathic arthritis (JIA), as a chronic condition, is associated with significant disease- and treatment-related morbidity, thus impacting children’s quality of life. In order to optimize JIA management, the paediatric rheumatologist has begun to regularly use measurements of disease activity developed, validated and endorsed by international paediatric rheumatology professional societies in an effort to monitor the disease course over time and assess the efficacy of therapeutic interventions in JIA patients.
A literature review was performed to describe the main outcome measures currently used in JIA patients to determine disease activity status.
The Juvenile Disease Activity Score (JADAS), in its different versions (classic JADAS, JADAS-CRP and cJADAS) and the validated definitions of disease activity and response to treatment represent an important tool for the assessment of clinically relevant changes in disease activity, leading more and more to a treat-to-target strategy, based on a tight and thorough control of the patient condition. Moreover, in recent years, increasing attention on the incorporation of patient-reported or parent-reported outcomes (PRCOs), when measuring the health state of patients with paediatric rheumatic diseases has emerged.
We think that the care of JIA patients cannot be possible without taking into account clinical outcome measures and, in this regard, further work is required.
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Metadata
Title
Clinical outcome measures in juvenile idiopathic arthritis
Authors
Alessandro Consolaro
Gabriella Giancane
Benedetta Schiappapietra
Sergio Davì
Serena Calandra
Stefano Lanni
Angelo Ravelli
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue 1/2016
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/s12969-016-0085-5

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