Skip to main content
Top
Published in: Knee Surgery, Sports Traumatology, Arthroscopy 10/2014

01-10-2014 | Knee

Clinical outcome after medial patellofemoral ligament reconstruction and autologous chondrocyte implantation following recurrent patella dislocation

Authors: Rainer Siebold, Georgios Karidakis, Francis Fernandez

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 10/2014

Login to get access

Abstract

Purpose

Medial patellofemoral ligament (MPFL) reconstruction is a well-established treatment option in recurrent patella dislocation. The combination with associated retropatellar cartilage lesions are severe injuries and very difficult to treat. The purpose of this study was to evaluate our clinical results of MPFL reconstruction and autologous chondrocyte implantation (ACI).

Methods

Thirteen patients with recurrent patella dislocation were treated with a combination of MPFL reconstruction and ACI at our institution between 2010 and 2014. All patients had at least 2 patella dislocations. The posttraumatic cartilage lesions were grade IV according to the ICRS and were localized retropatellar in 8 cases and at the lateral femoral condyle in 2 cases. The mean defect size was 7.2 ± 3.5 cm2 (3–12 cm2). Subjective and objective scores were assessed before surgery and at f/u, as well as radiologic parameters and cartilage status on magnetic resonance imaging (MRI).

Results

Ten patients (5 male, 5 female) with a mean follow-up of 2 years (minimum 1 year to 4 years) were enrolled in the study. At latest clinical follow-up, all patients had a stable patella with no signs of instability and all patients showed improved subjective and objective scores. Lysholm score increased to 74.1 ± 18.7 (48–99), KOOS score to 74.4 ± 16.9 (57–95), IKDC subjective to 63.9 ± 22.1 (34–93) and Kujala score to 73.8 ± 25.1 (50–100). The post-operative modified MOCART score for quality assessment of the ACI on MRI was an average of 13.7 ± 1.8 points (11–16), with a complete fill of the defect in 80 % of lesions.

Conclusion

Medial patellofemoral ligament reconstruction with simultaneous ACI showed good clinical results in recurrent patella dislocation with traumatic cartilage lesions grade IV. No patella re-dislocation occurred and the ACI was successful in 80 % of patients according to MRI. Subjective and objective scores improved but combined surgery is inferior to reports from the literature on MPFL reconstruction alone without cartilage damage.

Level of evidence

Therapeutic case series, Level IV.
Literature
1.
go back to reference Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331(14):889–895PubMedCrossRef Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331(14):889–895PubMedCrossRef
2.
go back to reference Brittberg M, Winalski CS (2003) Evaluation of cartilage injuries and repair. J Bone Joint Surg Am 85-A(Suppl 2):58–69PubMed Brittberg M, Winalski CS (2003) Evaluation of cartilage injuries and repair. J Bone Joint Surg Am 85-A(Suppl 2):58–69PubMed
3.
go back to reference Camp CL, Krych AJ, Dahm DL, Levy BA, Stuart MJ (2010) Medial patellofemoral ligament repair for recurrent patellar dislocation. Am J Sports Med 38(11):2248–2254PubMedCrossRef Camp CL, Krych AJ, Dahm DL, Levy BA, Stuart MJ (2010) Medial patellofemoral ligament repair for recurrent patellar dislocation. Am J Sports Med 38(11):2248–2254PubMedCrossRef
4.
go back to reference Diederichs G, Issever AS, Scheffler S (2010) MR imaging of patellar instability: injury patterns and assessment of risk factors. Radiographics 30(4):961–981PubMedCrossRef Diederichs G, Issever AS, Scheffler S (2010) MR imaging of patellar instability: injury patterns and assessment of risk factors. Radiographics 30(4):961–981PubMedCrossRef
5.
go back to reference Drez D Jr, Edwards TB, Williams CS (2001) Results of medial patellofemoral ligament reconstruction in the treatment of patellar dislocation. Arthroscopy 17(3):298–306PubMedCrossRef Drez D Jr, Edwards TB, Williams CS (2001) Results of medial patellofemoral ligament reconstruction in the treatment of patellar dislocation. Arthroscopy 17(3):298–306PubMedCrossRef
6.
go back to reference Ebert JR, Robertson WB, Woodhouse J, Fallon M, Zheng MH, Ackland T, Wood DJ (2011) Clinical and magnetic resonance imaging-based outcomes to 5 years after matrix-induced autologous chondrocyte implantation to address articular cartilage defects in the knee. Am J Sports Med 39(4):753–763PubMedCrossRef Ebert JR, Robertson WB, Woodhouse J, Fallon M, Zheng MH, Ackland T, Wood DJ (2011) Clinical and magnetic resonance imaging-based outcomes to 5 years after matrix-induced autologous chondrocyte implantation to address articular cartilage defects in the knee. Am J Sports Med 39(4):753–763PubMedCrossRef
7.
go back to reference Ferruzzi A, Buda R, Faldini C, Vannini F, Di Caprio F, Luciani D, Giannini S (2008) Autologous chondrocyte implantation in the knee joint: open compared with arthroscopic technique. Comparison at a minimum follow-up of five years. J Bone Joint Surg Am 90(Suppl 4):90–101PubMedCrossRef Ferruzzi A, Buda R, Faldini C, Vannini F, Di Caprio F, Luciani D, Giannini S (2008) Autologous chondrocyte implantation in the knee joint: open compared with arthroscopic technique. Comparison at a minimum follow-up of five years. J Bone Joint Surg Am 90(Suppl 4):90–101PubMedCrossRef
8.
go back to reference Fisher B, Nyland J, Brand E, Curtin B (2010) Medial patellofemoral ligament reconstruction for recurrent patellar dislocation: a systematic review including rehabilitation and return-to-sports efficacy. Arthroscopy 26(10):1384–1394PubMedCrossRef Fisher B, Nyland J, Brand E, Curtin B (2010) Medial patellofemoral ligament reconstruction for recurrent patellar dislocation: a systematic review including rehabilitation and return-to-sports efficacy. Arthroscopy 26(10):1384–1394PubMedCrossRef
9.
go back to reference Gigante A, Enea D, Greco F, Bait C, Denti M, Schonhuber H, Volpi P (2009) Distal realignment and patellar autologous chondrocyte implantation: mid-term results in a selected population. Knee Surg Sports Traumatol Arthrosc 17(1):2–10PubMedCrossRef Gigante A, Enea D, Greco F, Bait C, Denti M, Schonhuber H, Volpi P (2009) Distal realignment and patellar autologous chondrocyte implantation: mid-term results in a selected population. Knee Surg Sports Traumatol Arthrosc 17(1):2–10PubMedCrossRef
10.
go back to reference Gillogly SD, Arnold RM (2014) Autologous chondrocyte implantation and anteromedialization for isolated patellar articular cartilage lesions: 5- to 11-year follow-up. Am J Sports Med 42(4):912–920 Gillogly SD, Arnold RM (2014) Autologous chondrocyte implantation and anteromedialization for isolated patellar articular cartilage lesions: 5- to 11-year follow-up. Am J Sports Med 42(4):912–920
11.
go back to reference Gomoll AH, Farr J, Gillogly SD, Kercher J, Minas T (2010) Surgical management of articular cartilage defects of the knee. J Bone Joint Surg Am 92(14):2470–2490PubMed Gomoll AH, Farr J, Gillogly SD, Kercher J, Minas T (2010) Surgical management of articular cartilage defects of the knee. J Bone Joint Surg Am 92(14):2470–2490PubMed
12.
go back to reference Harris JD, Siston RA, Pan X, Flanigan DC (2010) Autologous chondrocyte implantation: a systematic review. J Bone Joint Surg Am 92(12):2220–2233PubMedCrossRef Harris JD, Siston RA, Pan X, Flanigan DC (2010) Autologous chondrocyte implantation: a systematic review. J Bone Joint Surg Am 92(12):2220–2233PubMedCrossRef
13.
go back to reference Hefti F, Muller W, Jakob RP, Staubli HU (1993) Evaluation of knee ligament injuries with the IKDC form. Knee Surg Sports Traumatol Arthrosc 1(3–4):226–234PubMedCrossRef Hefti F, Muller W, Jakob RP, Staubli HU (1993) Evaluation of knee ligament injuries with the IKDC form. Knee Surg Sports Traumatol Arthrosc 1(3–4):226–234PubMedCrossRef
14.
go back to reference Henderson IJ, Lavigne P (2006) Periosteal autologous chondrocyte implantation for patellar chondral defect in patients with normal and abnormal patellar tracking. Knee 13(4):274–279PubMedCrossRef Henderson IJ, Lavigne P (2006) Periosteal autologous chondrocyte implantation for patellar chondral defect in patients with normal and abnormal patellar tracking. Knee 13(4):274–279PubMedCrossRef
15.
go back to reference Kohn LM, Meidinger G, Beitzel K, Banke IJ, Hensler D, Imhoff AB, Schottle PB (2013) Isolated and combined medial patellofemoral ligament reconstruction in revision surgery for patellofemoral instability: a prospective study. Am J Sports Med 41(9):2128–2135PubMedCrossRef Kohn LM, Meidinger G, Beitzel K, Banke IJ, Hensler D, Imhoff AB, Schottle PB (2013) Isolated and combined medial patellofemoral ligament reconstruction in revision surgery for patellofemoral instability: a prospective study. Am J Sports Med 41(9):2128–2135PubMedCrossRef
16.
go back to reference Kujala UM, Jaakkola LH, Koskinen SK, Taimela S, Hurme M, Nelimarkka O (1993) Scoring of patellofemoral disorders. Arthroscopy 9(2):159–163PubMedCrossRef Kujala UM, Jaakkola LH, Koskinen SK, Taimela S, Hurme M, Nelimarkka O (1993) Scoring of patellofemoral disorders. Arthroscopy 9(2):159–163PubMedCrossRef
17.
go back to reference Lenschow S, Schliemann B, Gestring J, Herbort M, Schulze M, Kosters C (2013) Medial patellofemoral ligament reconstruction: fixation strength of 5 different techniques for graft fixation at the patella. Arthroscopy 29(4):766–773PubMedCrossRef Lenschow S, Schliemann B, Gestring J, Herbort M, Schulze M, Kosters C (2013) Medial patellofemoral ligament reconstruction: fixation strength of 5 different techniques for graft fixation at the patella. Arthroscopy 29(4):766–773PubMedCrossRef
18.
go back to reference Matsushita T, Kuroda R, Araki D, Kubo S, Matsumoto T, Kurosaka M (2013) Medial patellofemoral ligament reconstruction with lateral soft tissue release in adult patients with habitual patellar dislocation. Knee Surg Sports Traumatol Arthrosc 21(3):726–730PubMedCrossRef Matsushita T, Kuroda R, Araki D, Kubo S, Matsumoto T, Kurosaka M (2013) Medial patellofemoral ligament reconstruction with lateral soft tissue release in adult patients with habitual patellar dislocation. Knee Surg Sports Traumatol Arthrosc 21(3):726–730PubMedCrossRef
19.
go back to reference Niemeyer P, Porichis S, Steinwachs M, Erggelet C, Kreuz PC, Schmal H, Uhl M, Ghanem N, Sudkamp NP, Salzmann G (2014) Long-term outcomes after first-generation autologous chondrocyte implantation for cartilage defects of the knee. Am J Sports Med 42(1):150–157PubMedCrossRef Niemeyer P, Porichis S, Steinwachs M, Erggelet C, Kreuz PC, Schmal H, Uhl M, Ghanem N, Sudkamp NP, Salzmann G (2014) Long-term outcomes after first-generation autologous chondrocyte implantation for cartilage defects of the knee. Am J Sports Med 42(1):150–157PubMedCrossRef
20.
go back to reference Nomura E, Inoue M (2004) Cartilage lesions of the patella in recurrent patellar dislocation. Am J Sports Med 32(2):498–502PubMedCrossRef Nomura E, Inoue M (2004) Cartilage lesions of the patella in recurrent patellar dislocation. Am J Sports Med 32(2):498–502PubMedCrossRef
21.
go back to reference Nomura E, Inoue M (2005) Second-look arthroscopy of cartilage changes of the patellofemoral joint, especially the patella, following acute and recurrent patellar dislocation. Osteoarthr Cartil 13(11):1029–1036PubMedCrossRef Nomura E, Inoue M (2005) Second-look arthroscopy of cartilage changes of the patellofemoral joint, especially the patella, following acute and recurrent patellar dislocation. Osteoarthr Cartil 13(11):1029–1036PubMedCrossRef
22.
go back to reference Nomura E, Inoue M, Kobayashi S (2007) Long-term follow-up and knee osteoarthritis change after medial patellofemoral ligament reconstruction for recurrent patellar dislocation. Am J Sports Med 35(11):1851–1858PubMedCrossRef Nomura E, Inoue M, Kobayashi S (2007) Long-term follow-up and knee osteoarthritis change after medial patellofemoral ligament reconstruction for recurrent patellar dislocation. Am J Sports Med 35(11):1851–1858PubMedCrossRef
23.
go back to reference Panni AS, Alam M, Cerciello S, Vasso M, Maffulli N (2011) Medial patellofemoral ligament reconstruction with a divergent patellar transverse 2-tunnel technique. Am J Sports Med 39(12):2647–2655PubMedCrossRef Panni AS, Alam M, Cerciello S, Vasso M, Maffulli N (2011) Medial patellofemoral ligament reconstruction with a divergent patellar transverse 2-tunnel technique. Am J Sports Med 39(12):2647–2655PubMedCrossRef
24.
go back to reference Panni AS, Vasso M, Cerciello S (2013) Acute patellar dislocation. What to do? Knee Surg Sports Traumatol Arthrosc 21(2):275–278PubMedCrossRef Panni AS, Vasso M, Cerciello S (2013) Acute patellar dislocation. What to do? Knee Surg Sports Traumatol Arthrosc 21(2):275–278PubMedCrossRef
25.
go back to reference Pascual-Garrido C, Slabaugh MA, L’Heureux DR, Friel NA, Cole BJ (2009) Recommendations and treatment outcomes for patellofemoral articular cartilage defects with autologous chondrocyte implantation: prospective evaluation at average 4-year follow-up. Am J Sports Med 37(Suppl 1):33S–41SPubMedCrossRef Pascual-Garrido C, Slabaugh MA, L’Heureux DR, Friel NA, Cole BJ (2009) Recommendations and treatment outcomes for patellofemoral articular cartilage defects with autologous chondrocyte implantation: prospective evaluation at average 4-year follow-up. Am J Sports Med 37(Suppl 1):33S–41SPubMedCrossRef
26.
go back to reference Peterson L, Vasiliadis HS, Brittberg M, Lindahl A (2010) Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med 38(6):1117–1124PubMedCrossRef Peterson L, Vasiliadis HS, Brittberg M, Lindahl A (2010) Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med 38(6):1117–1124PubMedCrossRef
27.
go back to reference Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD (1998) Knee Injury and Osteoarthritis Outcome Score (KOOS)—development of a self-administered outcome measure. J Orthop Sports Phys Ther 28(2):88–96PubMedCrossRef Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD (1998) Knee Injury and Osteoarthritis Outcome Score (KOOS)—development of a self-administered outcome measure. J Orthop Sports Phys Ther 28(2):88–96PubMedCrossRef
28.
go back to reference Schottle PB, Schmeling A, Rosenstiel N, Weiler A (2007) Radiographic landmarks for femoral tunnel placement in medial patellofemoral ligament reconstruction. Am J Sports Med 35(5):801–804PubMedCrossRef Schottle PB, Schmeling A, Rosenstiel N, Weiler A (2007) Radiographic landmarks for femoral tunnel placement in medial patellofemoral ligament reconstruction. Am J Sports Med 35(5):801–804PubMedCrossRef
29.
go back to reference Siebold R, Borbon CA (2012) Arthroscopic extraarticular reconstruction of the medial patellofemoral ligament with gracilis tendon autograft—surgical technique. Knee Surg Sports Traumatol Arthrosc 20(7):1245–1251PubMedCrossRef Siebold R, Borbon CA (2012) Arthroscopic extraarticular reconstruction of the medial patellofemoral ligament with gracilis tendon autograft—surgical technique. Knee Surg Sports Traumatol Arthrosc 20(7):1245–1251PubMedCrossRef
30.
go back to reference Sillanpaa PJ, Mattila VM, Visuri T, Maenpaa H, Pihlajamaki H (2011) Patellofemoral osteoarthritis in patients with operative treatment for patellar dislocation: a magnetic resonance-based analysis. Knee Surg Sports Traumatol Arthrosc 19(2):230–235PubMedCrossRef Sillanpaa PJ, Mattila VM, Visuri T, Maenpaa H, Pihlajamaki H (2011) Patellofemoral osteoarthritis in patients with operative treatment for patellar dislocation: a magnetic resonance-based analysis. Knee Surg Sports Traumatol Arthrosc 19(2):230–235PubMedCrossRef
31.
go back to reference Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG (2003) Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy 19(5):477–484PubMedCrossRef Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG (2003) Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy 19(5):477–484PubMedCrossRef
32.
go back to reference Steiner TM, Torga-Spak R, Teitge RA (2006) Medial patellofemoral ligament reconstruction in patients with lateral patellar instability and trochlear dysplasia. Am J Sports Med 34(8):1254–1261PubMedCrossRef Steiner TM, Torga-Spak R, Teitge RA (2006) Medial patellofemoral ligament reconstruction in patients with lateral patellar instability and trochlear dysplasia. Am J Sports Med 34(8):1254–1261PubMedCrossRef
33.
go back to reference Steinwachs MR, Guggi T, Kreuz PC (2008) Marrow stimulation techniques. Injury 39(Suppl 1):S26–S31PubMedCrossRef Steinwachs MR, Guggi T, Kreuz PC (2008) Marrow stimulation techniques. Injury 39(Suppl 1):S26–S31PubMedCrossRef
34.
go back to reference Tegner Y, Lysholm J (1985) Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res 198:43–49PubMed Tegner Y, Lysholm J (1985) Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res 198:43–49PubMed
35.
go back to reference Tompkins M, Ma R, Hogan MV, Miller MD (2011) What’s new in sports medicine. J Bone Joint Surg Am 93(8):789–797PubMedCrossRef Tompkins M, Ma R, Hogan MV, Miller MD (2011) What’s new in sports medicine. J Bone Joint Surg Am 93(8):789–797PubMedCrossRef
36.
go back to reference Trinh TQ, Harris JD, Siston RA, Flanigan DC (2013) Improved outcomes with combined autologous chondrocyte implantation and patellofemoral osteotomy versus isolated autologous chondrocyte implantation. Arthroscopy 29(3):566–574PubMedCrossRef Trinh TQ, Harris JD, Siston RA, Flanigan DC (2013) Improved outcomes with combined autologous chondrocyte implantation and patellofemoral osteotomy versus isolated autologous chondrocyte implantation. Arthroscopy 29(3):566–574PubMedCrossRef
37.
go back to reference Vasiliadis HS, Lindahl A, Georgoulis AD, Peterson L (2011) Malalignment and cartilage lesions in the patellofemoral joint treated with autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc 19(3):452–457PubMedCrossRef Vasiliadis HS, Lindahl A, Georgoulis AD, Peterson L (2011) Malalignment and cartilage lesions in the patellofemoral joint treated with autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc 19(3):452–457PubMedCrossRef
38.
go back to reference Vollnberg B, Koehlitz T, Jung T, Scheffler S, Hoburg A, Khandker D, Hamm B, Wiener E, Diederichs G (2012) Prevalence of cartilage lesions and early osteoarthritis in patients with patellar dislocation. Eur Radiol 22(11):2347–2356PubMedCrossRef Vollnberg B, Koehlitz T, Jung T, Scheffler S, Hoburg A, Khandker D, Hamm B, Wiener E, Diederichs G (2012) Prevalence of cartilage lesions and early osteoarthritis in patients with patellar dislocation. Eur Radiol 22(11):2347–2356PubMedCrossRef
39.
go back to reference Watanabe A, Obata T, Ikehira H, Ueda T, Moriya H, Wada Y (2009) Degeneration of patellar cartilage in patients with recurrent patellar dislocation following conservative treatment: evaluation with delayed gadolinium-enhanced magnetic resonance imaging of cartilage. Osteoarthr Cartil 17(12):1546–1553PubMedCrossRef Watanabe A, Obata T, Ikehira H, Ueda T, Moriya H, Wada Y (2009) Degeneration of patellar cartilage in patients with recurrent patellar dislocation following conservative treatment: evaluation with delayed gadolinium-enhanced magnetic resonance imaging of cartilage. Osteoarthr Cartil 17(12):1546–1553PubMedCrossRef
40.
go back to reference Chow S, Shao J, Wang H (2008) Sample size calculations in clinical research, 2nd edn. Chapman & Hall/CRC Biostatistics Series, Boca Raton, Florida, p 100 Chow S, Shao J, Wang H (2008) Sample size calculations in clinical research, 2nd edn. Chapman & Hall/CRC Biostatistics Series, Boca Raton, Florida, p 100
Metadata
Title
Clinical outcome after medial patellofemoral ligament reconstruction and autologous chondrocyte implantation following recurrent patella dislocation
Authors
Rainer Siebold
Georgios Karidakis
Francis Fernandez
Publication date
01-10-2014
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 10/2014
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-014-3196-x

Other articles of this Issue 10/2014

Knee Surgery, Sports Traumatology, Arthroscopy 10/2014 Go to the issue