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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 7/2018

01-07-2018 | Review Article

Clinical implications of the deregulated TP73 isoforms expression in cancer

Authors: N. Rodríguez, A. Peláez, R. Barderas, G. Domínguez

Published in: Clinical and Translational Oncology | Issue 7/2018

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Abstract

TP73 is a member of the TP53 family whose expression has been observed altered in most human cancers and associated with the prognosis. TP73 translates into a complex number of isoforms with both oncogenic and tumour-suppressor functions and presents a complex cross-talk with other members of the family (TP53 and TP63). In this revision, we focus on the evidence that may support TP73 variants as prognostic markers in cancer. Nowadays, most publications in this topic highlight the association between overexpression of the oncogenic variants and failure to respond to chemotherapy and/or shorter survival. In addition, we comment on the putative possibilities that the detection through a liquid biopsy of TP73 variants may provide, and finally, the significance of determining the value of the combined alteration of the TP53 family members in the clinical setting.
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Metadata
Title
Clinical implications of the deregulated TP73 isoforms expression in cancer
Authors
N. Rodríguez
A. Peláez
R. Barderas
G. Domínguez
Publication date
01-07-2018
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 7/2018
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-017-1802-3

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