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01-11-2007 | Gastrointestinal Oncology

Clinical Implication of CXCL12 Expression in Gastric Cancer

Authors: Sumiya Ishigami, MD, PhD, Shoji Natsugoe, MD, PhD, Hiroshi Okumura, MD, PhD, Masataka Matsumoto, MD, PhD, Akihiro Nakajo, MD, PhD, Yoshikazu Uenosono, MD, PhD, Takaaki Arigami, MD, PhD, Yasuto Uchikado, MD, PhD, Tetsuro Setoyama, MD, PhD, Hideo Arima, MD, PhD, Shuichi Hokita, MD, PhD, Takashi Aikou, MD, PhD

Published in: Annals of Surgical Oncology | Issue 11/2007

Abstract

Purpose

Recent research has revealed that tumor cells expressing chemokine receptors have a crucial impact on patient survival. However, there is no information regarding chemokine expression in gastro-intestinal cancer. This study immunohistochemically investigated CXCL12 expression in gastric cancer and evaluated its association with clinical factors, including patient prognosis.

Method

A total of 185 gastric cancer patients receiving curative gastrectomy were assessed. CXCL12 expression was evaluated by immunohistochemical analysis. Tumors with CXCL12-positive cancer cells were regarded as CXCL12 positive, and according to the degree of CXCL12 expression, patients were divided into three groups (weak, 31 cases; moderate, 27 cases; strong, 20 cases). Correlations between CXCL12 expression and clinical factors in gastric cancer were then determined.

Results

CXCL12 was found in the cellular membrane of cancer cells. Seventy-four of 185 patients were classified into the CXCL12-positive group. Patients were divided into three groups according to the positivity of CXCL12 expression. Significant associations between CXCL12 and lymph node metastases (p < 0.05), depth of invasion (p < 0.01), lymphatic invasion (p < 0.01), tumor diameter (p < 0.05), and clinical stage (p < 0.01) were seen. Univariate analysis revealed that the CXCL12-positive group had significantly poorer surgical outcome than the CXCL12-negative group (p < 0.01). Multivariate analysis revealed CXCL12 to be an independent prognostic factor in gastric cancer (p = 0.02).

Conclusion

Cancerous CXCL12 positivity was determined to be an independent prognostic factor in gastric cancer, with CXCL12-positive gastric cancer showing more-aggressive behavior. Autocrine CXCL12 secretion from tumor cells may activate CXCR-4 on the tumor cells, which may be related to of the viability of distant metastases.

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Title: Clinical Implication of CXCL12 Expression in Gastric Cancer
Authors: Sumiya Ishigami, MD, PhD
Shoji Natsugoe, MD, PhD
Hiroshi Okumura, MD, PhD
Masataka Matsumoto, MD, PhD
Akihiro Nakajo, MD, PhD
Yoshikazu Uenosono, MD, PhD
Takaaki Arigami, MD, PhD
Yasuto Uchikado, MD, PhD
Tetsuro Setoyama, MD, PhD
Hideo Arima, MD, PhD
Shuichi Hokita, MD, PhD
Takashi Aikou, MD, PhD
Publication date: 01-11-2007
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 11/2007
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-007-9521-6

At a glance: The STEP trials

Springer Medicine

Clinical Implication of CXCL12 Expression in Gastric Cancer

Abstract

Purpose

Method

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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