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Published in:

01-06-2018 | Review Article

Clinical impact of molecular classifications in gastric cancer

Authors: Daniele Marrelli, Karol Polom, Alessandro Neri, Franco Roviello

Published in: Updates in Surgery | Issue 2/2018

Abstract

Treatment options to gastric cancer (GC) have been changing in recent years from a standard to a tailored approach. Different individualized procedures can range from endoscopic resection, D2 with open or minimally invasive approach, to neo-adjuvant therapy followed by extended surgery. In more advanced stages, a combined approach with the inclusion of intraperitoneal chemo-hyperthermia (HIPEC) may represent a new advanced option. The inclusion of histological type according to Laurén classification in the flowchart of treatment could increase both accuracy and effectiveness of such tailored approach. New molecular classifications of GC have been introduced recently and translational clinical studies are ongoing. These classifications are expected to be included in multidisciplinary treatment of GC. In particular, in the group with microsatellite instability a less extended lymphadenectomy may be proposed. Also tailored neo-adjuvant treatment may be proposed according to molecular classifications. The group of patients with epithelial-to-mesenchymal transition shows very high propensity to peritoneal dissemination, as well as N-metastases, and may benefit from prophylactic HIPEC and extended lymphadenectomy when confirmed in prospective trials.

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Title: Clinical impact of molecular classifications in gastric cancer
Authors: Daniele Marrelli
Karol Polom
Alessandro Neri
Franco Roviello
Publication date: 01-06-2018
Publisher: Springer International Publishing
Published in: Updates in Surgery / Issue 2/2018
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI: https://doi.org/10.1007/s13304-018-0546-0

At a glance: The STEP trials

Springer Medicine

Clinical impact of molecular classifications in gastric cancer

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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