Clinical factors associated with mortality within three months after radiosurgery of asymptomatic brain metastases from non-small cell lung cancer

go back to reference Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008) Non–Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship. Mayo Clin Proc 83:584–594CrossRefPubMed Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008) Non–Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship. Mayo Clin Proc 83:584–594CrossRefPubMed

go back to reference Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE (2016) Incidence Proportions of Brain Metastases in Patients Diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. https://doi.org/10.1200/JCO.2004.12.149 Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE (2016) Incidence Proportions of Brain Metastases in Patients Diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. https://​doi.​org/​10.​1200/​JCO.​2004.​12.​149

go back to reference Hazard LJ, Jensen RL, Shrieve DC (2005) Role of stereotactic radiosurgery in the treatment of brain metastases. Am J Clin Oncol 28:403–410CrossRefPubMed Hazard LJ, Jensen RL, Shrieve DC (2005) Role of stereotactic radiosurgery in the treatment of brain metastases. Am J Clin Oncol 28:403–410CrossRefPubMed

go back to reference Gavrilovic IT, Posner JB (2005) Brain metastases: epidemiology and pathophysiology. J Neurooncol 75:5–14. https://doi.org/10.1007/s11060-004-8093-6 CrossRefPubMed Gavrilovic IT, Posner JB (2005) Brain metastases: epidemiology and pathophysiology. J Neurooncol 75:5–14. https://​doi.​org/​10.​1007/​s11060-004-8093-6 CrossRefPubMed

go back to reference Sheehan JP, Yen CP, Nguyen J, Rainey JA, Dassoulas K, Schlesinger DJ (2011) Timing and risk factors for new brain metastasis formation in patients initially treated only with Gamma Knife surgery. Clinical article. J Neurosurg 114:763–768. https://doi.org/10.3171/2010.2.jns091539 CrossRefPubMed Sheehan JP, Yen CP, Nguyen J, Rainey JA, Dassoulas K, Schlesinger DJ (2011) Timing and risk factors for new brain metastasis formation in patients initially treated only with Gamma Knife surgery. Clinical article. J Neurosurg 114:763–768. https://​doi.​org/​10.​3171/​2010.​2.​jns091539 CrossRefPubMed

go back to reference Lutterbach J, Cyron D, Henne K, Ostertag CB (2003) Radiosurgery followed by planned observation in patients with one to three brain metastases. Neurosurgery 52:1066–1073; discussion 1073–1064PubMed Lutterbach J, Cyron D, Henne K, Ostertag CB (2003) Radiosurgery followed by planned observation in patients with one to three brain metastases. Neurosurgery 52:1066–1073; discussion 1073–1064PubMed

go back to reference Korones DN, Butterfield R, Meyers SP, Constine LS (2001) The role of surveillance magnetic resonance imaging (MRI) scanning in detecting recurrent brain tumors in asymptomatic children. J Neurooncol 53:33–38CrossRefPubMed Korones DN, Butterfield R, Meyers SP, Constine LS (2001) The role of surveillance magnetic resonance imaging (MRI) scanning in detecting recurrent brain tumors in asymptomatic children. J Neurooncol 53:33–38CrossRefPubMed

go back to reference Tamari K, Suzuki O, Hashimoto N, Kagawa N, Fujiwara M, Sumida I, Seo Y, Isohashi F, Yoshioka Y, Yoshimine T, Ogawa K (2015) Treatment outcomes using CyberKnife for brain metastases from lung cancer. J Radiat Res 56:151–158. https://doi.org/10.1093/jrr/rru092 CrossRefPubMed Tamari K, Suzuki O, Hashimoto N, Kagawa N, Fujiwara M, Sumida I, Seo Y, Isohashi F, Yoshioka Y, Yoshimine T, Ogawa K (2015) Treatment outcomes using CyberKnife for brain metastases from lung cancer. J Radiat Res 56:151–158. https://​doi.​org/​10.​1093/​jrr/​rru092 CrossRefPubMed

go back to reference Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, Sneed PK, Chao ST, Weil RJ, Suh J, Bhatt A, Jensen AW, Brown PD, Shih HA, Kirkpatrick J, Gaspar LE, Fiveash JB, Chiang V, Knisely JP, Sperduto CM, Lin N, Mehta M (2012) Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 30:419–425. https://doi.org/10.1200/jco.2011.38.0527 CrossRefPubMed Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, Sneed PK, Chao ST, Weil RJ, Suh J, Bhatt A, Jensen AW, Brown PD, Shih HA, Kirkpatrick J, Gaspar LE, Fiveash JB, Chiang V, Knisely JP, Sperduto CM, Lin N, Mehta M (2012) Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 30:419–425. https://​doi.​org/​10.​1200/​jco.​2011.​38.​0527 CrossRefPubMed

go back to reference Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG, Byhardt R (1997) Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37:745–751CrossRefPubMed Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG, Byhardt R (1997) Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37:745–751CrossRefPubMed

go back to reference Elaimy AL, Mackay AR, Lamoreaux WT, Fairbanks RK, Demakas JJ, Cooke BS, Peressini BJ, Holbrook JT, Lee CM (2011) Multimodality treatment of brain metastases: an institutional survival analysis of 275 patients. World J Surg Oncol 9:69. https://doi.org/10.1186/1477-7819-9-69 CrossRefPubMedPubMedCentral Elaimy AL, Mackay AR, Lamoreaux WT, Fairbanks RK, Demakas JJ, Cooke BS, Peressini BJ, Holbrook JT, Lee CM (2011) Multimodality treatment of brain metastases: an institutional survival analysis of 275 patients. World J Surg Oncol 9:69. https://​doi.​org/​10.​1186/​1477-7819-9-69 CrossRefPubMedPubMedCentral

go back to reference Gorovets D, Department of Radiation Oncology TMC, Department of Radiation Oncology USA, USA RIH, dgorovets@tuftsmedicalcenter.org, Rava P, Department of Radiation Oncology UMMC, Ebner USA, Department of Radiation Oncology DK, Tybor RIH,USA DJ, Department of Public Health and Community Medicine TUSoM, Cielo USA, D, Department of Neurosurgery RIH, USA, Puthawala Y, Department of Radiation Oncology RIH, Kinsella USA TJ, Department of Radiation Oncology RIH, USA, DiPetrillo TA, Department of Radiation Oncology TMC, USA, Department of Radiation Oncology RIH, USA, Wazer DE, Department of Radiation Oncology TMC, USA, Department of Radiation Oncology RIH, USA, Hepel JT, Department of Radiation Oncology TMC, USA, Department of Radiation Oncology RIH, USA (2015) Predictors for Long-Term Survival Free from Whole Brain Radiation Therapy in Patients Treated with Radiosurgery for Limited Brain Metastases. Frontiers in Oncology 5 https://doi.org/10.3389/fonc.2015.00110 Gorovets D, Department of Radiation Oncology TMC, Department of Radiation Oncology USA, USA RIH, dgorovets@tuftsmedicalcenter.org, Rava P, Department of Radiation Oncology UMMC, Ebner USA, Department of Radiation Oncology DK, Tybor RIH,USA DJ, Department of Public Health and Community Medicine TUSoM, Cielo USA, D, Department of Neurosurgery RIH, USA, Puthawala Y, Department of Radiation Oncology RIH, Kinsella USA TJ, Department of Radiation Oncology RIH, USA, DiPetrillo TA, Department of Radiation Oncology TMC, USA, Department of Radiation Oncology RIH, USA, Wazer DE, Department of Radiation Oncology TMC, USA, Department of Radiation Oncology RIH, USA, Hepel JT, Department of Radiation Oncology TMC, USA, Department of Radiation Oncology RIH, USA (2015) Predictors for Long-Term Survival Free from Whole Brain Radiation Therapy in Patients Treated with Radiosurgery for Limited Brain Metastases. Frontiers in Oncology 5 https://​doi.​org/​10.​3389/​fonc.​2015.​00110

go back to reference Weltman E, Salvajoli JV, Brandt RA, de Morais Hanriot R, Prisco FE, Cruz JC, de Oliveira Borges SR, Wajsbrot DB (2000) Radiosurgery for brain metastases: a score index for predicting prognosis. Int J Radiat Oncol Biol Phys 46:1155–1161CrossRefPubMed Weltman E, Salvajoli JV, Brandt RA, de Morais Hanriot R, Prisco FE, Cruz JC, de Oliveira Borges SR, Wajsbrot DB (2000) Radiosurgery for brain metastases: a score index for predicting prognosis. Int J Radiat Oncol Biol Phys 46:1155–1161CrossRefPubMed

go back to reference Sheehan JP, Sun MH, Kondziolka D, Flickinger J, Lunsford LD (2002) Radiosurgery for non-small cell lung carcinoma metastatic to the brain: long-term outcomes and prognostic factors influencing patient survival time and local tumor control. J Neurosurg 97:1276–1281. https://doi.org/10.3171/jns.2002.97.6.1276 CrossRefPubMed Sheehan JP, Sun MH, Kondziolka D, Flickinger J, Lunsford LD (2002) Radiosurgery for non-small cell lung carcinoma metastatic to the brain: long-term outcomes and prognostic factors influencing patient survival time and local tumor control. J Neurosurg 97:1276–1281. https://​doi.​org/​10.​3171/​jns.​2002.​97.​6.​1276 CrossRefPubMed

go back to reference Yamamoto M, Serizawa T, Shuto T, Akabane A, Higuchi Y, Kawagishi J, Yamanaka K, Sato Y, Jokura H, Yomo S, Nagano O, Kenai H, Moriki A, Suzuki S, Kida Y, Iwai Y, Hayashi M, Onishi H, Gondo M, Sato M, Akimitsu T, Kubo K, Kikuchi Y, Shibasaki T, Goto T, Takanashi M, Mori Y, Takakura K, Saeki N, Kunieda E, Aoyama H, Momoshima S, Tsuchiya K (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol 15:387–395. https://doi.org/10.1016/s1470-2045(14)70061-0 CrossRefPubMed Yamamoto M, Serizawa T, Shuto T, Akabane A, Higuchi Y, Kawagishi J, Yamanaka K, Sato Y, Jokura H, Yomo S, Nagano O, Kenai H, Moriki A, Suzuki S, Kida Y, Iwai Y, Hayashi M, Onishi H, Gondo M, Sato M, Akimitsu T, Kubo K, Kikuchi Y, Shibasaki T, Goto T, Takanashi M, Mori Y, Takakura K, Saeki N, Kunieda E, Aoyama H, Momoshima S, Tsuchiya K (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol 15:387–395. https://​doi.​org/​10.​1016/​s1470-2045(14)70061-0 CrossRefPubMed

go back to reference Network NCC (2013) The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Central Nervous System Cancers. Jornnal of the National Comprehensive Cancer Network Version 22013. https://doi.org/10.6004/jnccn.2013.0138 CrossRef Network NCC (2013) The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Central Nervous System Cancers. Jornnal of the National Comprehensive Cancer Network Version 22013. https://​doi.​org/​10.​6004/​jnccn.​2013.​0138 CrossRef

go back to reference Team RC (2014) R: A language and environment for statistical computing. 3.4.4 edn. R Foundation for Statistical Computing, Vienna Team RC (2014) R: A language and environment for statistical computing. 3.4.4 edn. R Foundation for Statistical Computing, Vienna

go back to reference Delattre JY, Krol G, Thaler HT, Posner JB (1988) Distribution of brain metastases. Arch Neurol 45:741–744CrossRefPubMed Delattre JY, Krol G, Thaler HT, Posner JB (1988) Distribution of brain metastases. Arch Neurol 45:741–744CrossRefPubMed

go back to reference Magnuson WJ, Lester-Coll NH, Wu AJ, Yang TJ, Lockney NA, Gerber NK, Beal K, Amini A, Patil T, Kavanagh BD, Camidge DR, Braunstein SE, Boreta LC, Balasubramanian SK, Ahluwalia MS, Rana NG, Attia A, Gettinger SN, Contessa JN, Yu JB, Chiang VL (2017) Management of Brain Metastases in Tyrosine Kinase Inhibitor-Naive Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer: A Retrospective Multi-Institutional Analysis. J Clin Oncol 35:1070–1077. https://doi.org/10.1200/jco.2016.69.7144 CrossRefPubMed Magnuson WJ, Lester-Coll NH, Wu AJ, Yang TJ, Lockney NA, Gerber NK, Beal K, Amini A, Patil T, Kavanagh BD, Camidge DR, Braunstein SE, Boreta LC, Balasubramanian SK, Ahluwalia MS, Rana NG, Attia A, Gettinger SN, Contessa JN, Yu JB, Chiang VL (2017) Management of Brain Metastases in Tyrosine Kinase Inhibitor-Naive Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer: A Retrospective Multi-Institutional Analysis. J Clin Oncol 35:1070–1077. https://​doi.​org/​10.​1200/​jco.​2016.​69.​7144 CrossRefPubMed

go back to reference Li C, Fang R, Sun Y, Han X, Li F, Gao B, Iafrate AJ, Liu XY, Pao W, Chen H, Ji H (2011) Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers. PLoS One 6:e28204. https://doi.org/10.1371/journal.pone.0028204 CrossRefPubMedPubMedCentral Li C, Fang R, Sun Y, Han X, Li F, Gao B, Iafrate AJ, Liu XY, Pao W, Chen H, Ji H (2011) Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers. PLoS One 6:e28204. https://​doi.​org/​10.​1371/​journal.​pone.​0028204 CrossRefPubMedPubMedCentral

go back to reference Matsumoto S, Takahashi K, Iwakawa R, Matsuno Y, Nakanishi Y, Kohno T, Shimizu E, Yokota J (2006) Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer 119:1491–1494. https://doi.org/10.1002/ijc.21940 CrossRefPubMed Matsumoto S, Takahashi K, Iwakawa R, Matsuno Y, Nakanishi Y, Kohno T, Shimizu E, Yokota J (2006) Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer 119:1491–1494. https://​doi.​org/​10.​1002/​ijc.​21940 CrossRefPubMed

go back to reference Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304:1497–1500. https://doi.org/10.1126/science.1099314 CrossRefPubMed Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304:1497–1500. https://​doi.​org/​10.​1126/​science.​1099314 CrossRefPubMed

go back to reference Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, Fujisawa T, Feng Z, Roth JA, Herz J, Minna JD, Gazdar AF (2005) Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97:339–346. https://doi.org/10.1093/jnci/dji055 CrossRefPubMed Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, Fujisawa T, Feng Z, Roth JA, Herz J, Minna JD, Gazdar AF (2005) Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97:339–346. https://​doi.​org/​10.​1093/​jnci/​dji055 CrossRefPubMed

go back to reference Iuchi T, Shingyoji M, Itakura M, Yokoi S, Moriya Y, Tamura H, Yoshida Y, Ashinuma H, Kawasaki K, Hasegawa Y, Sakaida T, Iizasa T (2015) Frequency of brain metastases in non-small-cell lung cancer, and their association with epidermal growth factor receptor mutations. Int J Clin Oncol 20:674–679. https://doi.org/10.1007/s10147-014-0760-9 CrossRefPubMed Iuchi T, Shingyoji M, Itakura M, Yokoi S, Moriya Y, Tamura H, Yoshida Y, Ashinuma H, Kawasaki K, Hasegawa Y, Sakaida T, Iizasa T (2015) Frequency of brain metastases in non-small-cell lung cancer, and their association with epidermal growth factor receptor mutations. Int J Clin Oncol 20:674–679. https://​doi.​org/​10.​1007/​s10147-014-0760-9 CrossRefPubMed

go back to reference Eichler AF, Kahle KT, Wang DL, Joshi VA, Willers H, Engelman JA, Lynch TJ, Sequist LV (2010) EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer. Neuro Oncol 12:1193–1199. https://doi.org/10.1093/neuonc/noq076 CrossRefPubMedPubMedCentral Eichler AF, Kahle KT, Wang DL, Joshi VA, Willers H, Engelman JA, Lynch TJ, Sequist LV (2010) EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer. Neuro Oncol 12:1193–1199. https://​doi.​org/​10.​1093/​neuonc/​noq076 CrossRefPubMedPubMedCentral

go back to reference Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP (2017) Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncol 3:827–831. https://doi.org/10.1001/jamaoncol.2016.3834 CrossRefPubMed Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP (2017) Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncol 3:827–831. https://​doi.​org/​10.​1001/​jamaoncol.​2016.​3834 CrossRefPubMed

go back to reference Lester SC, Taksler GB, Kuremsky JG, Lucas JT, Ayala-Peacock DN, Randolph DM, Bourland JD, Laxton AW, Tatter SB, Chan MD (2017) Clinical and economic outcomes of patients with brain metastases based on symptoms: An argument for routine brain screening of those treated with upfront radiosurgery. Cancer 120:433–441. https://doi.org/10.1002/cncr.28422 CrossRef Lester SC, Taksler GB, Kuremsky JG, Lucas JT, Ayala-Peacock DN, Randolph DM, Bourland JD, Laxton AW, Tatter SB, Chan MD (2017) Clinical and economic outcomes of patients with brain metastases based on symptoms: An argument for routine brain screening of those treated with upfront radiosurgery. Cancer 120:433–441. https://​doi.​org/​10.​1002/​cncr.​28422 CrossRef

go back to reference Sanchez de Cos J, Sojo Gonzalez MA, Montero MV, Perez Calvo MC, Vicente MJ, Valle MH (2009) Non-small cell lung cancer and silent brain metastasis. Survival and prognostic factors. Lung Cancer 63:140–145. https://doi.org/10.1016/j.lungcan.2008.04.013 CrossRefPubMed Sanchez de Cos J, Sojo Gonzalez MA, Montero MV, Perez Calvo MC, Vicente MJ, Valle MH (2009) Non-small cell lung cancer and silent brain metastasis. Survival and prognostic factors. Lung Cancer 63:140–145. https://​doi.​org/​10.​1016/​j.​lungcan.​2008.​04.​013 CrossRefPubMed

go back to reference Liu S, Qiu B, Chen L, Wang F, Liang Y, Cai P, Zhang L, Chen Z, Liu M, Liu H (2015) Radiotherapy for asymptomatic brain metastasis in epidermal growth factor receptor mutant non-small cell lung cancer without prior tyrosine kinase inhibitors treatment: a retrospective clinical study. Radiat Oncol 10:118. https://doi.org/10.1186/s13014-015-0421-9 CrossRefPubMedPubMedCentral Liu S, Qiu B, Chen L, Wang F, Liang Y, Cai P, Zhang L, Chen Z, Liu M, Liu H (2015) Radiotherapy for asymptomatic brain metastasis in epidermal growth factor receptor mutant non-small cell lung cancer without prior tyrosine kinase inhibitors treatment: a retrospective clinical study. Radiat Oncol 10:118. https://​doi.​org/​10.​1186/​s13014-015-0421-9 CrossRefPubMedPubMedCentral

go back to reference Magnuson WJ, Yeung JT, Guillod PD, Gettinger SN, Yu JB, Chiang VL (2016) Impact of Deferring Radiation Therapy in Patients With Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer Who Develop Brain Metastases. Int J Radiat Oncol Biol Phys 95:673–679. https://doi.org/10.1016/j.ijrobp.2016.01.037 CrossRefPubMed Magnuson WJ, Yeung JT, Guillod PD, Gettinger SN, Yu JB, Chiang VL (2016) Impact of Deferring Radiation Therapy in Patients With Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer Who Develop Brain Metastases. Int J Radiat Oncol Biol Phys 95:673–679. https://​doi.​org/​10.​1016/​j.​ijrobp.​2016.​01.​037 CrossRefPubMed

go back to reference Soria J-C, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, Dechaphunkul A, Imamura F, Nogami N, Kurata T, Okamoto I, Zhou C, Cho BC, Cheng Y, Cho EK, Voon PJ, Planchard D, Su W-C, Gray JE, Lee S-M, Hodge R, Marotti M, Rukazenkov Y, Ramalingam SS (2017) Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer. https://doi.org/10.1056/NEJMoa1713137 Soria J-C, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, Dechaphunkul A, Imamura F, Nogami N, Kurata T, Okamoto I, Zhou C, Cho BC, Cheng Y, Cho EK, Voon PJ, Planchard D, Su W-C, Gray JE, Lee S-M, Hodge R, Marotti M, Rukazenkov Y, Ramalingam SS (2017) Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer. https://​doi.​org/​10.​1056/​NEJMoa1713137

go back to reference Goss G, Tsai CM, Shepherd FA, Ahn MJ, Bazhenova L, Crino L, de Marinis F, Felip E, Morabito A, Hodge R, Cantarini M, Johnson M, Mitsudomi T, Janne PA, Yang JC (2018) CNS response to osimertinib in patients with T790M-positive advanced NSCLC: pooled data from two phase II trials. Ann Oncol 29:687–693. https://doi.org/10.1093/annonc/mdx820 CrossRefPubMed Goss G, Tsai CM, Shepherd FA, Ahn MJ, Bazhenova L, Crino L, de Marinis F, Felip E, Morabito A, Hodge R, Cantarini M, Johnson M, Mitsudomi T, Janne PA, Yang JC (2018) CNS response to osimertinib in patients with T790M-positive advanced NSCLC: pooled data from two phase II trials. Ann Oncol 29:687–693. https://​doi.​org/​10.​1093/​annonc/​mdx820 CrossRefPubMed

go back to reference Zindler JD, Jochems A, Lagerwaard FJ, Beumer R, Troost EGC, Eekers DBP, Compter I, van der Toorn PP, Essers M, Oei B, Hurkmans CW, Bruynzeel AME, Bosmans G, Swinnen A, Leijenaar RTH, Lambin P (2017) Individualized early death and long-term survival prediction after stereotactic radiosurgery for brain metastases of non-small cell lung cancer: Two externally validated nomograms. Radiother Oncol 123:189–194. https://doi.org/10.1016/j.radonc.2017.02.006 CrossRefPubMed Zindler JD, Jochems A, Lagerwaard FJ, Beumer R, Troost EGC, Eekers DBP, Compter I, van der Toorn PP, Essers M, Oei B, Hurkmans CW, Bruynzeel AME, Bosmans G, Swinnen A, Leijenaar RTH, Lambin P (2017) Individualized early death and long-term survival prediction after stereotactic radiosurgery for brain metastases of non-small cell lung cancer: Two externally validated nomograms. Radiother Oncol 123:189–194. https://​doi.​org/​10.​1016/​j.​radonc.​2017.​02.​006 CrossRefPubMed