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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 12/2017

01-12-2017 | Review

Clinical evaluation of macrophages in cancer: role in treatment, modulation and challenges

Authors: Liam Friel Tremble, Patrick F. Forde, Declan M. Soden

Published in: Cancer Immunology, Immunotherapy | Issue 12/2017

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Abstract

The focus of immunotherapeutics has been placed firmly on anti-tumour T cell responses. Significant progress has been made in the treatment of both local and systemic malignancies, but low response rates and rising toxicities are limiting this approach. Advancements in the understanding of tumour immunology are opening up a new range of therapeutic targets, including immunosuppressive factors in the tumour microenvironment. Macrophages are a heterogeneous group of cells that have roles in innate and adaptive immunity and tissue repair, but become co-opted by tumours to support tumour growth, survival, metastasis and immunosuppression. Macrophages also support tumour resistance to conventional therapy. In preclinical models, interference with macrophage migration, macrophage depletion and macrophage re-education have all been shown to reduce tumour growth and support anti-tumour immune responses. Here we discuss the role of macrophages in prognosis and sensitivity to therapy, while examining the significant progress which has been made in modulating the behaviour of these cells in cancer patients.
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Metadata
Title
Clinical evaluation of macrophages in cancer: role in treatment, modulation and challenges
Authors
Liam Friel Tremble
Patrick F. Forde
Declan M. Soden
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Cancer Immunology, Immunotherapy / Issue 12/2017
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-017-2065-0

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