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Published in: Trials 1/2009

Open Access 01-12-2009 | Study protocol

Clinical e valuation of magnetic resonance imaging in coronary heart disease: The CE-MARC study

Authors: John P Greenwood, Neil Maredia, Aleksandra Radjenovic, Julia M Brown, Jane Nixon, Amanda J Farrin, Catherine Dickinson, John F Younger, John P Ridgway, Mark Sculpher, Stephen G Ball, Sven Plein

Published in: Trials | Issue 1/2009

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Abstract

Background

Several investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment of myocardial function, perfusion, viability and coronary artery anatomy. However, data from large scale studies that prospectively evaluate the diagnostic accuracy of multi-parametric CMR for the detection of CHD in unselected populations are lacking, and there are few data on the performance of CMR compared with current diagnostic tests, its prognostic value and cost-effectiveness.

Methods/design

This is a prospective diagnostic accuracy cohort study of 750 patients referred to a cardiologist with suspected CHD. Exercise tolerance testing (ETT) will be preformed if patients are physically able. Recruited patients will then undergo CMR and single photon emission tomography (SPECT) followed in all patients by invasive X-ray coronary angiography. The order of the CMR and SPECT tests will be randomised. The CMR study will comprise rest and adenosine stress perfusion, cine imaging, late gadolinium enhancement and whole-heart MR coronary angiography. SPECT will use a gated stress/rest protocol. The primary objective of the study is to determine the diagnostic accuracy of CMR in detecting significant coronary stenosis, as defined by X-ray coronary angiography. Secondary objectives include an assessment of the prognostic value of CMR imaging, a comparison of its diagnostic accuracy against SPECT and ETT, and an assessment of cost-effectiveness.

Discussion

The CE-MARC study is a prospective, diagnostic accuracy cohort study of 750 patients assessing the performance of a multi-parametric CMR study in detecting CHD using invasive X-ray coronary angiography as the reference standard and comparing it with ETT and SPECT.

Trial Registration

Current Controlled Trials ISRCTN77246133
Appendix
Available only for authorised users
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Metadata
Title
Clinical e valuation of magnetic resonance imaging in coronary heart disease: The CE-MARC study
Authors
John P Greenwood
Neil Maredia
Aleksandra Radjenovic
Julia M Brown
Jane Nixon
Amanda J Farrin
Catherine Dickinson
John F Younger
John P Ridgway
Mark Sculpher
Stephen G Ball
Sven Plein
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Trials / Issue 1/2009
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-10-62

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