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BMC Medicine
Published in: BMC Medicine 1/2013

Open Access 01-12-2013 | Review

Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases

Authors: Michela Flego, Alessandro Ascione, Maurizio Cianfriglia, Stefano Vella

Published in: BMC Medicine | Issue 1/2013

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Abstract

Today there are many licensed antiviral drugs, but the emergence of drug resistant strains sometimes invalidates the effects of the current therapies used in the treatment of infectious diseases. Compared to conventional antiviral drugs, monoclonal antibodies (mAbs) used as pharmacological molecules have particular physical characteristics and modes of action, and, therefore, they should be considered as a distinct therapeutic class. Despite being historically validated, antibodies may represent a novel tool for combatting infectious diseases. The current high cost of mAbs' production, storage and administration (by injection only) and the consequent obstacles to development are outweighed by mAbs' clinical advantages. These are related to a low toxicity combined with high specificity and versatility, which allows a specific antibody to mediate various biological effects, ranging from the virus neutralization mechanisms to the modulation of immune responses.
This review briefly summarizes the recent technological advances in the field of immunoglobulin research, and the current status of mAb-based drugs in clinical trials for HIV and HCV diseases. For each clinical trial the available data are reported and the emerging conceptual problems of the employed mAbs are highlighted.
This overview helps to give a clear picture of the efficacy and challenges of the mAbs in the field of these two infectious diseases which have such a global impact.
Appendix
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Metadata
Title
Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases
Authors
Michela Flego
Alessandro Ascione
Maurizio Cianfriglia
Stefano Vella
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2013
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/1741-7015-11-4

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