Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Research article

Clinical characteristics and prognosis of 272 postterm choriocarcinoma patients at Peking Union Medical College Hospital: a retrospective cohort study

Authors: Jie Li, Junjun Yang, Pengfei Liu, Tong Ren, Jun Zhao, Fengzhi Feng, Xirun Wan, Yang Xiang

Published in: BMC Cancer | Issue 1/2016

Login to get access

Abstract

Background

The objective of our study was to investigate the clinical characteristics and prognosis of postterm choriocarcinoma patients at Peking Union Medical College Hospital within the past 30 years.

Methods

The clinical characteristics and pertinent follow-up data of 272 patients with postterm choriocarcinoma diagnosed from December 1985 through December 2014 in our hospital were reviewed. The clinical characteristics of two cohorts cut off at 2006 were compared using χ 2 tests. Risk factors of prognosis were estimated by multivariate Cox proportional regression analysis.

Results

The most common initial symptom was abnormal uterine bleeding. After individualized treatment 239 patients (87.9 %) achieved complete remission, including 140 patients received initial treatment of 5-fluorouracil-based multidrug chemotherapy. There were almost no statistically significant differences in the clinical characteristics and survival rates between the two cohorts. The results of the multivariate analysis showed that history of resistance to multidrug chemotherapy, liver metastasis and FIGO score greater than 12 were independent risk factors of prognosis.

Conclusions

Postterm choriocarcinoma patients were usually accompanied by several high-risk factors that should received combined chemotherapy to prevent delay in adequate treatment. 5-fluorouracil-based multidrug chemotherapy, which has been applied at PUMCH for several decades, can be an effective initial treatment for postterm choriocarcinoma patients. More emphasis should be placed on those who have history of resistance to multidrug chemotherapy, liver metastasis or a FIGO score greater than 12.
Appendix
Available only for authorised users
Literature
1.
Ngan HYS, Kohorn EI, Cole LA, Kurman RJ, Kim SJ, Lurain JR, et al. FIGO Cancer Report 2012 Trophoblastic disease. Int J Gynecol Obstet. 2012;119S2:S130–6.CrossRef
2.
Mangili G, Lorusso D, Brown J, Pfisterer J, Massuger L, Vaughan M, et al. Trophoblastic Disease Review for Diagnosis and Management A Joint Report From the International Society for the study of Trophoblastic Disease, European Organization for the treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer. 2014;24:S109–16.CrossRefPubMed
3.
Bagshawe KD, Dent J, Webb J. Hydatidiform mole in England and Wales 1973–1983. Lancet. 1986;2:673–7.CrossRefPubMed
4.
Bower M, Newlands ES, Holden L, Short D, Brock C, Rustin GJ, et al. EMA/CO for high-risk gestational trophoblastic tumors: results from a cohort of 272 patients. J Clin Oncol. 1997;15(7):2636–43.PubMed
5.
Lybol C, Centen D, Thomas C, ten Kate-Booij M, Verheijen R, Sweep F, et al. Fatal cases of gestational trophoblastic neoplasia over four decades in the Netherlands: a retrospective cohort study. BJOG. 2012;119:1465–72.CrossRefPubMed
6.
Ma Y, Xiang Y, Wan XR, Chen Y, Feng FZ, Lei CZ, et al. The prognosis analysis of 123 postpartum choriocarcinoma cases. Int J Gynecol Cancer. 2008;18:1097–101.CrossRefPubMed
7.
Lok CA, Ansink AC, Grootfaam D, van der Velden J, Verheijen RH, ten Kate-Booij M. Treatment and prognosis of post term choriocarcinoma in The Netherlands. Gynecol Oncol. 2006;103:698–702.CrossRefPubMed
8.
Ryu N, Ogawa M, Matsui H, Usui H, Shozu M. The Clinical Characteristics and Early Detection of Postpartum Choriocarcinoma. Int J Gynecol Cancer. 2014;25:926–30.CrossRef
9.
10.
Diver E, May T, Vargas R, Bernstein M, Goldstein D, Berkowtiz R. Changes in clinical presentation of postterm choriocarcinoma at the New England Trophoblastic Diseae Center in recent years. Gynecol Oncol. 2013;130:483–6.CrossRefPubMed
11.
Odunsi KO, Peck LL, Kohorn EI, Parkash V, Cracchiolo B, Chambers JT, et al. Necrosis of Myometrial Choriocarcinoma with Fulminating Sepsis Complicating Chemotherapy for Trophoblastic Tumor. Gynecol Oncol. 1998;70:100–4.CrossRefPubMed
12.
Feng F, Xiang Y, Wan X, Geng S, Wang T. Salvage combination chemotherapy with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) for patients with relapsed/chemoresistant gestational trophoblastic neoplasia. Ann Oncol. 2011;22(7):1588–94.CrossRefPubMed
13.
Yang J, Xiang Y, Wan X, Feng F, Ren T. Analysis of the prognosis and related factors for patients with stage IV gestational trophoblastic neoplasia. Int J Gynecol Cancer. 2014;24:594–9.CrossRefPubMed
14.
Xiao CJ, Yang JJ, Zhao J, Ren T, Feng FZ, Wan XR, et al. Management and prognosis of patients with brain metastasis from gestational trophoblastic neoplasia: a 24-year experience in Peking union medical college hospital. BMC Cancer. 2015;15:318–26.CrossRefPubMedPubMedCentral
15.
Rodabaugh KJ, Bernstein MR, Goldstein D, Berkowtiz R. Natural history of postterm choriocarcinoma. J Reprod Med. 1998;43(1):75–80.PubMed
16.
Olive DL, Lurain JR, Brewer JI. Choriocarcinoma associated with term gestation. Am J Obstet Gynecol. 1984;148(6):711–6.CrossRefPubMed
Metadata
Title
Clinical characteristics and prognosis of 272 postterm choriocarcinoma patients at Peking Union Medical College Hospital: a retrospective cohort study
Authors
Jie Li
Junjun Yang
Pengfei Liu
Tong Ren
Jun Zhao
Fengzhi Feng
Xirun Wan
Yang Xiang
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2383-1

Other articles of this Issue 1/2016

BMC Cancer 1/2016 Go to the issue

Research article

The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

Research article

Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation

Research article

Pretreatment neutrophil-to-lymphocyte ratio predicts the prognosis in patients with metastatic prostate cancer

Research article

Evaluation of the role of remission status in a heterogeneous limited disease small-cell lung cancer patient cohort treated with definitive chemoradiotherapy

Research article

Prognostic value of HER2 status in bladder transitional cell carcinoma revealed by both IHC and BDISH techniques

Technical advance

In chronic myeloid leukemia patients on second-line tyrosine kinase inhibitor therapy, deep sequencing of BCR-ABL1 at the time of warning may allow sensitive detection of emerging drug-resistant mutants
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits