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01-05-2015 | Rhinosinusitis (J Mullol, Section Editor)

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

Authors: Mauricio López-Chacón, Joaquim Mullol, Laura Pujols

Published in: Current Allergy and Asthma Reports | Issue 5/2015

Abstract

Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled by treatment and have a poor quality of life. It is highly important to identify both clinical and biological markers, so-called biomarkers, in this subset of patients. The presence of nasal polyps and comorbidity with asthma and with aspirin-exacerbated respiratory disease (AERD) are the most common clinical traits that have been associated to difficult-to-treat severe CRS. In addition to clinical traits, numerous biological markers, with known etiopathogenic roles in CRS, have been associated to difficult-to-treat or recalcitrant CRS. This review summarizes the existing knowledge of the clinical and biological markers associated to difficult-to-treat or uncontrolled severe CRS.

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Title: Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis
Authors: Mauricio López-Chacón
Joaquim Mullol
Laura Pujols
Publication date: 01-05-2015
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 5/2015
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-015-0520-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

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Keynote webinar | Spotlight on medication adherence

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