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Published in: Esophagus 2/2016

01-04-2016 | Original Article

Clinical analysis of the diagnosis and treatment of esophageal perforation

Authors: Hiroshi Okumura, Yasuto Uchikado, Yoshiaki Kita, Itaru Omoto, Naoki Hayashi, Masataka Matsumoto, Ken Sasaki, Tetsuro Setoyama, Takaaki Arigami, Yoshikazu Uenosono, Daisuke Matsushita, Ryosuke Desaki, Masahiro Noda, Naotomo Higo, Keishi Okubo, Masakazu Urata, Yoichi Yamasaki, Tetsuhiro Owaki, Sumiya Ishigami, Shoji Natsugoe

Published in: Esophagus | Issue 2/2016

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Abstract

Background

Despite recent advances in treatment strategies, the management of esophageal perforation is still problematical and controversial. The purpose of the present study was to evaluate and compare the clinical data, treatment methods, and outcomes of patients with esophageal perforation according to the patients’ systemic condition (shock, systemic inflammatory response syndrome (SIRS), or non-SIRS) on arrival to the hospital.

Methods

Twelve patients were treated for an esophageal perforation between 2004 and 2013. Based on the patients’ pretreatment status, the patients were divided into three groups (shock, SIRS, and non-SIRS groups), and their clinical findings, treatment methods, and outcomes were compared.

Results

The numbers of patients in the shock, SIRS, and non-SIRS groups were three, three, and six, respectively. There was a difference in etiologies among the three groups as follows: two patients with spontaneous rupture were in the shock group, two patients with tumor perforation were in the SIRS group, four patients with foreign body were in the non-SIRS group, and patients with iatrogenic causes were included in all groups. The treatment procedures included conservative therapy in 4 non-SIRS patients, primary surgical repair in 4 patients (2 SIRS, 2 non-SIRS), resection in one SIRS patient, and conservative treatment with minor surgical approaches or stenting in 3 shock patients. The mortality rate was 0 %.

Conclusion

Tailoring the treatment strategy to the systemic condition of patients with esophageal perforation is important. In particular, patients with shock should be treated conservatively with minor surgical approaches, including temporary stent insertion.
Literature
1.
go back to reference Jones WG 2nd, Ginsberg RJ. Esophageal perforation: a continuing challenge. Ann Thorac Surg. 1992;53:534–43.CrossRefPubMed Jones WG 2nd, Ginsberg RJ. Esophageal perforation: a continuing challenge. Ann Thorac Surg. 1992;53:534–43.CrossRefPubMed
2.
go back to reference Reeder LB, De Filippi VJ, Ferguson MK. Current results of therapy for esophageal perforation. Am J Surg. 1995;169:615–7.CrossRefPubMed Reeder LB, De Filippi VJ, Ferguson MK. Current results of therapy for esophageal perforation. Am J Surg. 1995;169:615–7.CrossRefPubMed
3.
go back to reference Okten I, Cangir AK, Ozdemir N, Kavukçu S, Akay H, Yavuzer S. Management of esophageal perforation. Surg Today. 2001;31:36–9.CrossRefPubMed Okten I, Cangir AK, Ozdemir N, Kavukçu S, Akay H, Yavuzer S. Management of esophageal perforation. Surg Today. 2001;31:36–9.CrossRefPubMed
4.
go back to reference Kiernan PD, Rhee J, Collazo L, Byrne WD, Fulcher T, Hettrick V, Vaughan B, Graling P. Thoracic esophageal perforations. South Med. 2003;96:158–63.CrossRef Kiernan PD, Rhee J, Collazo L, Byrne WD, Fulcher T, Hettrick V, Vaughan B, Graling P. Thoracic esophageal perforations. South Med. 2003;96:158–63.CrossRef
5.
go back to reference Gupta NM, Kaman L. Personal management of 57 consecutive patients with esophageal perforation. Am J Surg. 2004;187:58–63.CrossRefPubMed Gupta NM, Kaman L. Personal management of 57 consecutive patients with esophageal perforation. Am J Surg. 2004;187:58–63.CrossRefPubMed
6.
go back to reference Jougon J, McBride T, Delcambre F, Minniti A, Velly JF. Primary esophageal repair for Boerhaave’s syndrome whatever the free interval between perforation and treatment. Eur J Cardiothorac Surg. 2004;25:475–9.CrossRefPubMed Jougon J, McBride T, Delcambre F, Minniti A, Velly JF. Primary esophageal repair for Boerhaave’s syndrome whatever the free interval between perforation and treatment. Eur J Cardiothorac Surg. 2004;25:475–9.CrossRefPubMed
7.
go back to reference Zumbro GL, Anstadt MP, Mawulawde K, Bhimji S, Paliotta MA, Pai G. Surgical management of esophageal perforation: role of esophageal conservation in delayed perforation. Am Surg. 2002;68:36–40.PubMed Zumbro GL, Anstadt MP, Mawulawde K, Bhimji S, Paliotta MA, Pai G. Surgical management of esophageal perforation: role of esophageal conservation in delayed perforation. Am Surg. 2002;68:36–40.PubMed
8.
go back to reference Kollmar O, Lindemann W, Richter S, Schilling MK. Boerhaave’s syndrome: primary repair vs. esophageal resection: case reports and meta-analysis of the literature. J Gastrointest Surg. 2003;7:726–34.CrossRefPubMed Kollmar O, Lindemann W, Richter S, Schilling MK. Boerhaave’s syndrome: primary repair vs. esophageal resection: case reports and meta-analysis of the literature. J Gastrointest Surg. 2003;7:726–34.CrossRefPubMed
9.
go back to reference Martinez L, Rivas S, Hernández F, Avila LF, Lassaletta L, Murcia J, Olivares P, Queizán A, Fernandez A, López-Santamaría M, Tovar JA. Aggressive conservative treatment of esophageal perforations in children. J Pediatr Surg. 2003;38:685–9.CrossRefPubMed Martinez L, Rivas S, Hernández F, Avila LF, Lassaletta L, Murcia J, Olivares P, Queizán A, Fernandez A, López-Santamaría M, Tovar JA. Aggressive conservative treatment of esophageal perforations in children. J Pediatr Surg. 2003;38:685–9.CrossRefPubMed
10.
go back to reference Vogel SB, Rout WR, Martin TD, Abbitt PL. Esophageal perforation in adults: aggressive, conservative treatment lowers morbidity and mortality. Ann Surg. 2005;241:1016–21 (discussion 1021–23).CrossRefPubMedPubMedCentral Vogel SB, Rout WR, Martin TD, Abbitt PL. Esophageal perforation in adults: aggressive, conservative treatment lowers morbidity and mortality. Ann Surg. 2005;241:1016–21 (discussion 1021–23).CrossRefPubMedPubMedCentral
11.
go back to reference Furugaki K, Yoshida J, Hokazono K, Emoto T, Nakashima J, Ohyama M, Ishimitsu T, Shinohara M, Matsuo K. Esophageal ruptures: triage using the systemic inflammatory response syndrome score. Gen Thorac Cardiovasc Surg. 2011;59:220–4.CrossRefPubMed Furugaki K, Yoshida J, Hokazono K, Emoto T, Nakashima J, Ohyama M, Ishimitsu T, Shinohara M, Matsuo K. Esophageal ruptures: triage using the systemic inflammatory response syndrome score. Gen Thorac Cardiovasc Surg. 2011;59:220–4.CrossRefPubMed
12.
go back to reference Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, SCCM, ESICM, ACCP, ATS, SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med. 2003;31:1250–6.CrossRefPubMed Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, SCCM, ESICM, ACCP, ATS, SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med. 2003;31:1250–6.CrossRefPubMed
13.
go back to reference Moy MP, Levsky JM, Berko NS, Godelman A, Jain VR, Haramati LB. A new, simple method for estimating pleural effusion size on CT scans. Chest. 2013;143:1054–9.CrossRefPubMedPubMedCentral Moy MP, Levsky JM, Berko NS, Godelman A, Jain VR, Haramati LB. A new, simple method for estimating pleural effusion size on CT scans. Chest. 2013;143:1054–9.CrossRefPubMedPubMedCentral
14.
go back to reference Cameron JL, Kieffer RF, Hendrix TR, Mehigan DG, Baker RR. Selective nonoperative management of contained intrathoracic esophageal disruptions. Ann Thorac Surg. 1979;27:404–8.CrossRefPubMed Cameron JL, Kieffer RF, Hendrix TR, Mehigan DG, Baker RR. Selective nonoperative management of contained intrathoracic esophageal disruptions. Ann Thorac Surg. 1979;27:404–8.CrossRefPubMed
16.
go back to reference Brown RH, Cohne PS. Nonsurgical management of spontaneous esophageal perforation. JAMA. 1978;240:140–2.CrossRefPubMed Brown RH, Cohne PS. Nonsurgical management of spontaneous esophageal perforation. JAMA. 1978;240:140–2.CrossRefPubMed
17.
go back to reference Darrien JH, Kasem H. Minimally invasive endoscopic therapy for the management of Boerhaave’s syndrome. Ann R Coll Surg Engl. 2013;95:552–6.PubMedPubMedCentral Darrien JH, Kasem H. Minimally invasive endoscopic therapy for the management of Boerhaave’s syndrome. Ann R Coll Surg Engl. 2013;95:552–6.PubMedPubMedCentral
18.
go back to reference Schweigert M, Beattie R, Solymosi N, Booth K, Dubecz A, Muir A, Moskorz K, Stadlhuber RJ, Ofner D, McGuigan J, Stein HJ. Endoscopic stent insertion versus primary operative management for spontaneous rupture of the esophagus (Boerhaave syndrome): an international study comparing the outcome. Am Surg. 2013;79:634–40.PubMed Schweigert M, Beattie R, Solymosi N, Booth K, Dubecz A, Muir A, Moskorz K, Stadlhuber RJ, Ofner D, McGuigan J, Stein HJ. Endoscopic stent insertion versus primary operative management for spontaneous rupture of the esophagus (Boerhaave syndrome): an international study comparing the outcome. Am Surg. 2013;79:634–40.PubMed
19.
go back to reference El Hajj II, Imperiale TF, Rex DK, Ballard D, Kesler KA, Birdas TJ, Fatima H, Kessler WR, Dewitt JM. Treatment of esophageal leaks, fistulae, and perforations with temporary stents: evaluation of efficacy, adverse events, and factors associated with successful outcomes. Gastrointest Endosc. 2014;79:589–98.CrossRefPubMed El Hajj II, Imperiale TF, Rex DK, Ballard D, Kesler KA, Birdas TJ, Fatima H, Kessler WR, Dewitt JM. Treatment of esophageal leaks, fistulae, and perforations with temporary stents: evaluation of efficacy, adverse events, and factors associated with successful outcomes. Gastrointest Endosc. 2014;79:589–98.CrossRefPubMed
20.
go back to reference Oshiro T, Kasama K, Umezawa A, Kanehira E, Kurokawa Y. Successful management of refractory staple line leakage at the esophagogastric junction after a sleeve gastrectomy using the HANAROSTENT. Obes Surg. 2010;20:530–4.CrossRefPubMed Oshiro T, Kasama K, Umezawa A, Kanehira E, Kurokawa Y. Successful management of refractory staple line leakage at the esophagogastric junction after a sleeve gastrectomy using the HANAROSTENT. Obes Surg. 2010;20:530–4.CrossRefPubMed
21.
go back to reference Inbar R, Santo E, Subchi A-A, Korianski J, Halperin Z, Greenberg R, Avital S. Insertion of removable self-expanding metal stents as a treatment for postoperative leaks and perforations of the esophagus and stomach. Isr Med Assoc J. 2011;13:230–3.PubMed Inbar R, Santo E, Subchi A-A, Korianski J, Halperin Z, Greenberg R, Avital S. Insertion of removable self-expanding metal stents as a treatment for postoperative leaks and perforations of the esophagus and stomach. Isr Med Assoc J. 2011;13:230–3.PubMed
Metadata
Title
Clinical analysis of the diagnosis and treatment of esophageal perforation
Authors
Hiroshi Okumura
Yasuto Uchikado
Yoshiaki Kita
Itaru Omoto
Naoki Hayashi
Masataka Matsumoto
Ken Sasaki
Tetsuro Setoyama
Takaaki Arigami
Yoshikazu Uenosono
Daisuke Matsushita
Ryosuke Desaki
Masahiro Noda
Naotomo Higo
Keishi Okubo
Masakazu Urata
Yoichi Yamasaki
Tetsuhiro Owaki
Sumiya Ishigami
Shoji Natsugoe
Publication date
01-04-2016
Publisher
Springer Japan
Published in
Esophagus / Issue 2/2016
Print ISSN: 1612-9059
Electronic ISSN: 1612-9067
DOI
https://doi.org/10.1007/s10388-015-0504-6

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