Published in:
Open Access
01-12-2011 | Poster presentation
CLARITY: C hiL dhood A rthritis R isk Factor I dentification ST udY. Investigating the role of aberrant DNA methylation in juvenile idiopathic arthritis
Authors:
JA Ellis, R Chavez, L Gordon, AL Ponsonby, B Lim, J Akikusa, R Allen, R Saffery, J Craig, JE Munro
Published in:
Pediatric Rheumatology
|
Special Issue 1/2011
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Excerpt
Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disorder likely to be determined by multiple genetic and environmental factors. Mounting evidence shows that epigenetic variation influences autoimmune disease risk. The most well-studied epigenetic mark is DNA methylation; increased methylation of CpG dinucleotides can reduce gene expression. Nothing is currently known about the role of methylation in JIA. In 2008, we established CLARITY, a JIA Biobank that is collecting biospecimens and extensive information about environment from cases presenting to the Royal Children’s Hospital (RCH), Melbourne, Australia. A control sample of healthy children attending the RCH Day Surgery Unit has also been collected. …
