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Breast Cancer Research
Published in: Breast Cancer Research 5/2013

01-10-2013 | Review

Circulating nucleic acids as biomarkers in breast cancer

Author: Heidi Schwarzenbach

Published in: Breast Cancer Research | Issue 5/2013

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Abstract

During tumor development, tumor cells release their nucleic acids into the blood circulation. This process occurs by apoptotic and necrotic cell deaths along with active cell secretion, resulting in high levels of circulating DNA, mRNA, and microRNA in the blood of patients with breast cancer. As circulating cell-free tumor nucleic acids may reflect the characteristics of the primary tumor and even of micrometastatic cells, they may be excellent blood biomarkers for screening breast cancer. Assays that allow the repetitive monitoring of patients by using blood samples as liquid biopsy may be efficient in assessing cancer progression in patients whose tumor tissue is not available. This review evaluates the recent data on the potential use of circulating cell-free nucleic acids as biomarkers for breast cancer.
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Metadata
Title
Circulating nucleic acids as biomarkers in breast cancer
Author
Heidi Schwarzenbach
Publication date
01-10-2013
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2013
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3446

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