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01-09-2017 | Original Article

Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults

Authors: J. Coulson, L. Bagley, Y. Barnouin, S. Bradburn, G. Butler-Browne, H. Gapeyeva, J.-Y. Hogrel, T. Maden-Wilkinson, A. B. Maier, C. Meskers, C. Murgatroyd, M. Narici, M. Pääsuke, L. Sassano, S. Sipilä, N. AL-Shanti, L. Stenroth, D. A. Jones, J. S. McPhee

Published in: Osteoporosis International | Issue 9/2017

Abstract

Summary

Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.

Introduction

This study aims to investigate the relationship between whole-body bone mineral density (WBMD) and levels of circulating factors with known roles in bone remodelling during ‘healthy’ ageing.

Methods

WBMD and fasting plasma concentrations of dickkopf-1, fibroblast growth factor-23, osteocalcin, osteoprotegerin, osteopontin and sclerostin were measured in 272 older subjects (69 to 81 years; 52% female) and 171 younger subjects (18–30 years; 53% female).

Results

WBMD was lower in old than young. Circulating osteocalcin was lower in old compared with young, while dickkopf-1, osteoprotegerin and sclerostin were higher in old compared with young. These circulating factors were each positively associated with WBMD in the older adults and the relationships remained after adjustment for covariates (r values ranging from 0.174 to 0.254, all p < 0.01). In multivariate regression, the body mass index, circulating sclerostin and whole-body lean mass together accounted for 13.8% of the variation with WBMD in the older adults. In young adults, dickkopf-1 and body mass index together accounted for 7.7% of variation in WBMD.

Conclusion

Circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin are positively associated with WBMD in community-dwelling older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.

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Title: Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults
Authors: J. Coulson
L. Bagley
Y. Barnouin
S. Bradburn
G. Butler-Browne
H. Gapeyeva
J.-Y. Hogrel
T. Maden-Wilkinson
A. B. Maier
C. Meskers
C. Murgatroyd
M. Narici
M. Pääsuke
L. Sassano
S. Sipilä
N. AL-Shanti
L. Stenroth
D. A. Jones
J. S. McPhee
Publication date: 01-09-2017
Publisher: Springer London
Published in: Osteoporosis International / Issue 9/2017
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-017-4104-2

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Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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