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Critical Care
Published in: Critical Care 6/2012

01-12-2012 | Letter

Circulating fatty acid binding protein as a marker of intestinal failure in septic patients

Authors: Marcel Cerqueira César Machado, Hermes Vieira Barbeiro, Fabiano Pinheiro da Silva, Heraldo Possolo de Souza

Published in: Critical Care | Issue 6/2012

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Excerpt

Intestinal hypoperfusion in sepsis may result in loss of gut barrier and bacterial translocation, further complicating the already severe septic state. Intestinal dysfunction in critically ill patients is underestimated and may be associated with worse prognosis. The absence of a valid marker of intestinal dysfunction in sepsis makes it difficult to include this parameter in a patient's clinical evaluation. We describe intestinal fatty acid-binding protein as a marker of intestinal failure in septic shock. …
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Literature
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Piton G, Manzon C, Cypriani B, Carbonnel F, Capellier G: Acute intestinal failure in critically ill patients: is plasma citrulline the right marker?. Intensive Care Med. 2011, 37: 911-917. 10.1007/s00134-011-2172-x.CrossRefPubMed
2.
Vermeulen Windsant IC, Hellenthal FA, Derikx JP, Prins MH, Buurman WA, Jacobs MJ, Schurink GW: Circulating intestinal fatty acid-binding protein as an early marker of intestinal necrosis after aortic surgery: a prospective observational cohort study. Ann Surg. 2012, 255: 796-803. 10.1097/SLA.0b013e31824b1e16.CrossRefPubMed
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Dello SA, Reisinger KW, van Dam RM, Bemelmans MH, van Kuppevelt TH, van den Broek MA, Olde Damink SW, Poeze M, Buurman WA, Dejong CH: Total intermittent Pringle maneuver during liver resection can induce intestinal epithelial cell damage and endotoxemia. PLoS One. 2012, 7: e30539-10.1371/journal.pone.0030539.PubMedCentralCrossRefPubMed
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Pan L, Wang X, Li W, Li N, Li J: The intestinal fatty acid binding protein diagnosing gut dysfunction in acute pancreatitis: a pilot study. Pancreas. 2010, 39: 633-638. 10.1097/MPA.0b013e3181c79654.CrossRefPubMed
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Pelsers MM, Hermens WT, Glatz JF: Fatty acid-binding proteins as plasma markers of tissue injury. Clin Chim Acta. 2005, 352: 15-35. 10.1016/j.cccn.2004.09.001.CrossRefPubMed
Metadata
Title
Circulating fatty acid binding protein as a marker of intestinal failure in septic patients
Authors
Marcel Cerqueira César Machado
Hermes Vieira Barbeiro
Fabiano Pinheiro da Silva
Heraldo Possolo de Souza
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11653

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