Published in:
01-01-2017 | Images in Hematology
Chronic NK lymphocytosis identified by a distinct immunophenotypic pattern
Published in: International Journal of Hematology | Issue 1/2017
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We investigated a 55-year-old Chinese female for persistent mild neutropenia. Apart from weight loss of 3 kg over the past year, she was otherwise well with no abnormal physical findings. Full blood count showed white blood cell (WBC) count 5.44 × 109/L, absolute neutrophils 1.8 × 109/L, absolute lymphocyte 3.1 × 109/L, hemoglobin concentration 11.9 g/dL, and platelet count 306 × 109/L. Blood film showed large granular lymphocytes (LGL) (4 %) (Fig. 1a, b). Screening tests for autoimmune disorders, Epstein–Barr virus infection, and HIV infection were negative. Chest X-ray and ultrasound scan of the abdomen were normal, except for stones in the gallbladder.
Fig. 1
a, b Large granular lymphocytes in the peripheral blood film. c–l Multiparametric flow cytometry assay showing two distinct populations of NK cells in the peripheral blood; red abnormal NK cells, blue normal NK cells, yellow T-lymphocytes, gray other events in an erythrocyte-lysed sample
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