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01-04-2014 | Neurology and Preclinical Neurological Studies - Short communication

Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

Authors: Jasmin Bartl, Thomas Müller, Edna Grünblatt, Manfred Gerlach, Peter Riederer

Published in: Journal of Neural Transmission | Issue 4/2014

Abstract

Patients with Parkinson’s disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70 % reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily.

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Title: Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity
Authors: Jasmin Bartl
Thomas Müller
Edna Grünblatt
Manfred Gerlach
Peter Riederer
Publication date: 01-04-2014
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 4/2014
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1120-z

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Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

Abstract

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Abstract

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