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BMC Nephrology
Published in: BMC Nephrology 1/2023

Open Access 01-12-2023 | Chronic Kidney Disease | Research

Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis

Authors: Fan Zhang, Hui Wang, Yan Bai, Ying Zhang, Liuyan Huang, Huachun Zhang

Published in: BMC Nephrology | Issue 1/2023

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Abstract

Background

Frailty is common in chronic kidney disease (CKD) patients and becomes more prevalent as kidney disease progresses. This study aimed to investigate the prevalence of physical frailty and quantify the relationship between frailty and mortality risk in patients with CKD.

Methods

PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, Clinicaltrial.gov, and major renal academic conferences were systematically searched, and additional references to relevant articles were manually searched. The prevalence of physical frailty and the risk of mortality based on random-effects models were assessed using percentages and hazard ratio (HR) with a 95% confidence interval (CI).

Results

A total of 139 articles, including 1,675,482 participants, met the eligibility criteria for the meta-analysis. The results showed that 34.5% (95% CI 31.0 to 38.1%) of CKD patients showed signs of frailty, and 39.4% (95% CI 35.4 to 43.5%) had prefrail symptoms. Compared to non-frail patients, the risk of mortality was increased by 94.1% (95% CI 1.586 to 2.375) in frail patients and 34.5% (95% CI 1.231 to 1.469) in prefrail patients.

Conclusion

The high prevalence of frailty and prefrail in adults with CKD and resulting in premature death emphasize the importance of measuring frailty, which provides important prognostic information and may provide opportunities for interventions to improve the prognosis of patients with CKD.
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Metadata
Title
Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis
Authors
Fan Zhang
Hui Wang
Yan Bai
Ying Zhang
Liuyan Huang
Huachun Zhang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2023
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-023-03303-1

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