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Pediatric Nephrology

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05-05-2023 | Chronic Kidney Disease | Original Article

Dietary acid load in children with chronic kidney disease: its association with nutritional status and health-related quality of life

Authors: Gamze Yurtdaş Depboylu, Gülşah Kaner, Özgür Özdemir Şimşek, Kübra Nur Turan, Belde Kasap Demir

Published in: Pediatric Nephrology | Issue 10/2023

Abstract

Background

This study aimed to determine the dietary acid load of children with chronic kidney disease (CKD) and to evaluate the relationship between dietary acid load, nutritional status, and health-related quality of life (HRQOL).

Method

A total of 67 children aged 3–18 years with a diagnosis of CKD stages II–V were included in the study. Anthropometric measurements (body weight, height, mid-upper arm circumference, waist, and neck circumference) and 3-day food consumption records were taken to evaluate the nutritional status. The net endogenous acid production (NEAP) score was calculated to determine the dietary acid load. “Pediatric Inventory of Quality of Life (PedsQL)” was used to assess the participants’ HRQOL.

Results

The mean NEAP was 59.2 ± 18.96 mEq/day. Stunted and malnourished children had significantly higher NEAP than those who were not (p < 0.05). There were no significant differences in terms of HRQOL scores according to NEAP groups. The multivariate logistic regression analysis showed that waist circumference (OR: 0.890, 95% CI: 0.794–0.997), serum albumin (OR: 0.252, 95% CI: 0.068–0.929), and glomerular filtration rate (GFR) (OR: 0.985, 95% CI: 0.970–1.000) were negatively associated with high NEAP.

Conclusion

This study shows that a diet shifted in an acidic direction in children with CKD and a higher dietary acid load are associated with lower serum albumin, GFR, and waist circumference, but not HRQOL. These results suggest that dietary acid load might affect nutritional status and CKD progression in children with CKD. Future studies with larger samples are needed to confirm these results and to understand underlying mechanisms.

Graphical abstract

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Title: Dietary acid load in children with chronic kidney disease: its association with nutritional status and health-related quality of life
Authors: Gamze Yurtdaş Depboylu
Gülşah Kaner
Özgür Özdemir Şimşek
Kübra Nur Turan
Belde Kasap Demir
Publication date: 05-05-2023
Publisher: Springer Berlin Heidelberg
Keyword: Chronic Kidney Disease
Published in: Pediatric Nephrology / Issue 10/2023
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-05991-1

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Springer Medicine

Dietary acid load in children with chronic kidney disease: its association with nutritional status and health-related quality of life

Abstract

Background

Method

Results

Conclusion

Graphical abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusion

Graphical abstract

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