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BMC Public Health
Published in: BMC Public Health 1/2024

Open Access 01-12-2024 | Chronic Kidney Disease | Research

Associations between Life’s Essential 8 and abdominal aortic calcification among US Adults: a cross-sectional study

Authors: Quanjun Liu, Hong Xiang, Shuhua Chen, Jie Ouyang, Huiqin Liu, Jing Zhang, Yanfei Chai, Peng Gao, Xiao Zhang, Jianing Fan, Xinru Zheng, Hongwei Lu

Published in: BMC Public Health | Issue 1/2024

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Abstract

Background

Cardiovascular health (CVH) and abdominal aortic calcification (AAC) are closely linked to cardiovascular disease (CVD) and related mortality. However, the relationship between CVH metrics via Life’s Essential 8 (LE8) and AAC remains unexplored.

Methods

The study analyzed data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) cohort, which included adults aged 40 or above. The research used the LE8 algorithm to evaluate CVH. Semi-quantitative AAC-24 scoring techniques were employed to assess AAC, categorized into no calcification, mild to moderate calcification, and severe calcification.

Results

The primary analysis involved 2,478 participants. Following adjustments for multiple factors, the LE8 score exhibited a significant association with ACC risk (Mild-moderate ACC: 0.87, 95% CI: 0.81,0.93; Severe ACC: 0.77, 95% CI: 0.69,0.87, all P < 0.001), indicating an almost linear dose–response relationship. Compared to the low CVH group, the moderate CVH group showed lower odds ratios (OR) for mild-moderate and severe calcification (OR = 0.78, 95% CI: 0.61–0.99, P = 0.041; OR = 0.68, 95% CI: 0.46–0.99, P = 0.047, respectively). Moreover, the high CVH group demonstrated even lower ORs for mild-moderate and severe calcification (OR = 0.46, 95% CI: 0.31, 0.69, P < 0.001; OR = 0.29, 95% CI: 0.14, 0.59, P = 0.001, respectively). Interactions were found between chronic kidney disease (CKD) condition, history of CVD, marital status and CVH metrics to ACC. Participants without CKD exhibited a more pronounced negative association between the CVH metric and both mild-moderate and severe ACC. Those lacking a history of CVD, and never married/widowed/divorced/separated showed a stronger negative association between the CVH metric and severe ACC.

Conclusions

The novel CVH metrics demonstrated an inverse correlation with the risk of AAC. These findings suggest that embracing improved CVH levels may assist in alleviating the burden of ACC.
Appendix
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Metadata
Title
Associations between Life’s Essential 8 and abdominal aortic calcification among US Adults: a cross-sectional study
Authors
Quanjun Liu
Hong Xiang
Shuhua Chen
Jie Ouyang
Huiqin Liu
Jing Zhang
Yanfei Chai
Peng Gao
Xiao Zhang
Jianing Fan
Xinru Zheng
Hongwei Lu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-024-18622-7

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