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Open Access 01-12-2020 | Research article

Choroidal vascularity index as a biomarker of systemic inflammation in childhood Polyarteritis Nodosa and adenosine deaminase-2 deficiency

Authors: Ata BAYTAROĞLU, Sibel KADAYIFÇILAR, Abdullah AĞIN, Özge DELİKTAŞ, Selcan DEMİR, Yelda BİLGİNER, Jale KARAKAYA, Seza ÖZEN, Bora ELDEM

Published in: Pediatric Rheumatology | Issue 1/2020

Abstract

Background/purpose

To assess EDI-OCT (enhanced depth imaging optical coherence tomography) of choroid for inflammatory signs in children with polyarteritis nodosa (PAN) and adenosine deaminase-2 deficiency (DADA-2).

Methods

In this cross-sectional study conducted between June 2017 and September 2018, we evaluated children diagnosed with PAN (n = 11) and DADA-2 (n = 4) and an age- and sex-matched control group (n = 15). Demographic and laboratory data were retrospectively analyzed from patient charts. Disease activity was assessed using the pediatric vasculitis activity score (PVAS). Choroidal images were obtained with spectral domain-OCT to measure choroidal thickness (ChT) at 5 points (750 and 1500 μm from the foveal center in the temporal and nasal quadrants and beneath the fovea), and to calculate the total subfoveal choroidal area (TCA), luminal area (LA), stromal area (SA), and the choroidal vascularity index (CVI).

Results

The median (min-max) age was 8 (4–16) years in PAN patients, 6 (5–16) years in DADA-2 patients and 8 (8–10) years in control group at the OCT visit (p = 0.214). The ChT at 3 points and the TCA, LA, and SA were higher in children with both PAN and DADA-2 patients compared to those of the control group (p < 0.0001, p = 0.049, p = 0.007, p = 0.007, p = 0.006, p = 0.033, respectively). The CVI was similar in both groups. No association was observed between the OCT findings, PVAS, and the erythrocyte sedimentation rate, and serum leukocyte and C-reactive protein levels.

Conclusion

Similar CVI scores were obtained from PAN and DADA2 patients under treatment and from healthy controls. Increased subfoveal ChT without any other signs of ocular involvement may suggest choroidal thickening as a sign of mild subclinical inflammation.

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Title: Choroidal vascularity index as a biomarker of systemic inflammation in childhood Polyarteritis Nodosa and adenosine deaminase-2 deficiency
Authors: Ata BAYTAROĞLU
Sibel KADAYIFÇILAR
Abdullah AĞIN
Özge DELİKTAŞ
Selcan DEMİR
Yelda BİLGİNER
Jale KARAKAYA
Seza ÖZEN
Bora ELDEM
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue 1/2020
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/s12969-020-0417-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Choroidal vascularity index as a biomarker of systemic inflammation in childhood Polyarteritis Nodosa and adenosine deaminase-2 deficiency

Abstract

Background/purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background/purpose

Methods

Results

Conclusion

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