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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-08-2008 | Case Report

Choroidal plasmacytoma in a patient with multiple myeloma. Diagnosis by fine-needle aspiration biopsy

Authors: Melis Palamar, Carol L. Shields, Fariba Ghassemi, Hormoz Ehya, Jerry A. Shields

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 8/2008

Abstract

Background

To report a case of a secondary plasmacytoma of the choroid.

Methods

Interventional case report with cytopathologic correlation.

Results

A 61-year-old male with a breast nodule and a 2-year history of multiple myeloma developed blurred vision and was found to have three confluent, ill-defined areas of choroidal thickening in the left eye. Cytopathology and immunohistochemistry of a transocular fine-needle aspiration biopsy of the largest lesion revealed atypical plasma cells diagnostic of plasmacytoma. Following external beam radiotherapy the choroidal tumors resolved completely.

Conclusion

Secondary plasmacytoma, despite its rarity, should be included in the differential diagnosis of amelanotic choroidal tumors, particularly in patients with multiple myeloma. Radiotherapy is an effective treatment.

Shields JA, Shields CL (2006) Intraocular involvement with other lymphoid lesions. In: Shields JA, Shields CL (eds) Intraocular Tumors. An Atlas and Textbook. Lippincott Williams & Wilkins, Philadelphia, pp 504–533

Adkins JW, Shields JA, Shields CL et al (1997) Plasmacytoma of the eye and orbit. Int Ophthalmol 20(6):339–343CrossRef

Thoumazet F, Donnio A, Ayeboua L et al (2006) Orbital and muscle involvement in multiple myeloma. Can J Ophthalmol 41(6):733–736PubMedCrossRef

Goldstein DA, Schteingart MT, Birnbaum AD et al (2005) Bilateral eyelid ecchymoses and corneal crystals: an unusual presentation of multiple myeloma. Cornea 24:757–758PubMedCrossRef

Honavar SG, Shields JA, Shields CL et al (2001) Extramedullary plasmacytoma confined to the choroid. Am J Ophthalmol 131:277–278PubMedCrossRef

Shields CL, Chong WH, Ehya H et al (2007) Sequential bilateral solitary extramedullary plasmacytoma of the ciliary body. Cornea 26:759–761PubMedCrossRef

Shakin EP, Augsburger JJ, Eagle RC et al (1988) Multiple myeloma involving the iris. Arch Ophthalmol 106:524–526PubMed

Morgan AE, Shields CL, Shields JA et al (2003) Presumed malignant plasmacytoma as the first manifestation of multiple myeloma. Retina 23:867–868PubMedCrossRef

Title: Choroidal plasmacytoma in a patient with multiple myeloma. Diagnosis by fine-needle aspiration biopsy
Authors: Melis Palamar
Carol L. Shields
Fariba Ghassemi
Hormoz Ehya
Jerry A. Shields
Publication date: 01-08-2008
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 8/2008
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-008-0804-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Choroidal plasmacytoma in a patient with multiple myeloma. Diagnosis by fine-needle aspiration biopsy

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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