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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 5/2024

22-02-2024 | Cholangiocarcinoma | ASO Author Reflections

ASO Author Reflections: Early-Onset Intrahepatic Cholangiocarcinoma—Poor Oncological Outcomes and Distinct Molecular Features

Authors: Diamantis I. Tsilimigras, MD, Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA, FACS, FRACS (Hon.)

Published in: Annals of Surgical Oncology | Issue 5/2024

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Excerpt

The annual incidence of intrahepatic cholangiocarcinoma (ICC) has increased among individuals younger than 50 years of age.1,2 Age-specific differences in biologic behavior of ICC may exist, yet largely remain not investigated.3 In particular, little is known about the incidence, clinical characteristics, and outcomes of patients with early-onset ICC. To this end, we sought to define the clinical characteristics and outcomes of patients undergoing resection of early (≤ 50 years) versus late onset (> 50 years) ICC, as well as characterize the molecular features of each ICC subtype that may drive variations in prognosis following ICC resection.4 …
Literature
1.
Florio AA, Ferlay J, Znaor A, et al. Global trends in intrahepatic and extrahepatic cholangiocarcinoma incidence from 1993 to 2012. Cancer. 2020;126(11):2666–78.CrossRefPubMed
2.
Gad MM, Saad AM, Faisaluddin M, et al. Epidemiology of cholangiocarcinoma; United States incidence and mortality trends. Clin Res Hepatol Gastroenterol. 2020;44(6):885–93.CrossRefPubMed
3.
Feng H, Tong H, Yan J, He M, Chen W, Wang J. Genomic features and clinical characteristics of adolescents and young adults with cholangiocarcinoma. Front Oncol. 2019;9:1439.CrossRefPubMed
4.
Metadata
Title
ASO Author Reflections: Early-Onset Intrahepatic Cholangiocarcinoma—Poor Oncological Outcomes and Distinct Molecular Features
Authors
Diamantis I. Tsilimigras, MD
Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA, FACS, FRACS (Hon.)
Publication date
22-02-2024
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 5/2024
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-15098-y

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