Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Journal of General Internal Medicine
Published in: Journal of General Internal Medicine 8/2021

01-08-2021 | Chloroquin | Letter to the Editor

Reply to the Letter to Editor by Lacout and colleagues: Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: a Systematic Review and Meta-analysis

Authors: Manya Prasad, MD, Arunmozhimaran Elavarasi, MD, Pramod Garg, MD

Published in: Journal of General Internal Medicine | Issue 8/2021

Login to get access

Excerpt

We thank Lacout and colleagues for their comments on our systematic review and meta-analysis.1 The authors propose that early use (e.g., ≤3 days since symptom onset) of hydroxychloroquine (HCQ) may be associated with better outcomes in patients with COVID-19. However, the available evidence including 3 recent randomized controlled trials (RCTs) has failed to show benefit of HCQ even in patients with shorter symptom duration and milder illness at baseline and those who were not hospitalized, or when used for post-exposure prophylaxis. …
Literature
1.
Elavarasi A, Prasad M, Seth T, Sahoo RK, Madan K, Nischal N, et al. Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: a Systematic Review and Meta-analysis. J Gen Intern Med. 2020 Nov;35(11):3308-3314. doi: https://​doi.​org/​10.​1007/​s11606-020-06146-w. Epub 2020 Sep 3.
2.
Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, et al. A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19. New England Journal of Medicine. 2020 Aug 6;383(6):517–25.CrossRef
3.
Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, et al. Effect of hydroxychloroquine on clinical status at 14 days in hospitalized patients with COVID-19: a randomized clinical trial. JAMA. 2020 Dec 1;324(21):2165–76.CrossRef
4.
Cavalcanti AB, Zampieri FG, Rosa RG, Azevedo LCP, Veiga VC, Avezum A, et al. Hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19. New England Journal of Medicine. 2020 Nov 19;383(21):2041–52.CrossRef
5.
Ladapo JA, McKinnon JE, McCullough PA, Risch H. Randomized controlled trials of early ambulatory hydroxychloroquine in the prevention of COVID-19 infection, hospitalization, and death: meta-analysis. medRxiv. 2020 Jan 1;2020.09.30.20204693.
Metadata
Title
Reply to the Letter to Editor by Lacout and colleagues: Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: a Systematic Review and Meta-analysis
Authors
Manya Prasad, MD
Arunmozhimaran Elavarasi, MD
Pramod Garg, MD
Publication date
01-08-2021
Publisher
Springer International Publishing
Published in
Journal of General Internal Medicine / Issue 8/2021
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-021-06722-8

Other articles of this Issue 8/2021

Journal of General Internal Medicine 8/2021 Go to the issue

Innovations in Medical Education

The ACLGIM LEAD Program: a Leadership Program for Junior-Mid-Career Faculty

Original Research

Challenges to Addressing Patient-Perpetrated Sexual Harassment in Veterans Affairs Healthcare Settings

Research and Reporting Methods

Development, Validation, and Performance of a New Physical Functioning–Weighted Multimorbidity Index for Use in Administrative Data

Concise Research Report

Overcoming Barriers to Early Dementia Diagnosis and Management in Primary Care

Original Research

Call Center Remote Triage by Nurse Practitioners Was Associated With Fewer Subsequent Face-to-Face Healthcare Visits

Concise Research Report

Mental Distress and Mental Health Services Receipt in Foreign-Born Survivors of Cancer: a National Health Interview Survey Analysis
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits