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Published in: Journal of Ophthalmic Inflammation and Infection 1/2013

Open Access 01-12-2013 | Review

Chikungunya and the eye: a review

Authors: Padmamalini Mahendradas, Kavitha Avadhani, Rohit Shetty

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2013

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Abstract

Chikungunya is a self-limited, systemic viral infection that has been a major health problem since the past few years. Ocular manifestations of the disease have become more prevalent in the recent years. Currently, there is neither a specific treatment nor vaccine available for chikungunya fever. This review highlights the current understanding on the pathogenesis, systemic changes with an emphasis on ocular findings, laboratory investigations, and prevention and treatment of this disease.
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Literature
1.
go back to reference Mohan A: Chikungunya fever: clinical manifestations & management. Indian J Med Res 2006, 124: 471–474.PubMed Mohan A: Chikungunya fever: clinical manifestations & management. Indian J Med Res 2006, 124: 471–474.PubMed
2.
go back to reference Mohan A, Sharma SK: Chikungunya fever. In Medicine update. Edited by: Singal RK. Association of Physicians of India, Mumbai; 2007:634–638. Mohan A, Sharma SK: Chikungunya fever. In Medicine update. Edited by: Singal RK. Association of Physicians of India, Mumbai; 2007:634–638.
3.
go back to reference Mohan A: Chikungunya fever strikes in Andhra Pradesh. Natl Med J India 2006, 19: 240. Mohan A: Chikungunya fever strikes in Andhra Pradesh. Natl Med J India 2006, 19: 240.
4.
go back to reference Simon F, Savini H, Parola P: Chikungunya: a paradigm of emergence and globalization of vector-borne diseases. Med Clin North Am 2008, 92: 1323–1343. 10.1016/j.mcna.2008.07.008PubMedCrossRef Simon F, Savini H, Parola P: Chikungunya: a paradigm of emergence and globalization of vector-borne diseases. Med Clin North Am 2008, 92: 1323–1343. 10.1016/j.mcna.2008.07.008PubMedCrossRef
5.
go back to reference Pialoux G, Gaüzère BA, Jauréguiberry S, Strobel M: Chikungunya, an epidemic arbovirosis. Lancet Infect Dis 2007, 7: 319–327. 10.1016/S1473-3099(07)70107-XPubMedCrossRef Pialoux G, Gaüzère BA, Jauréguiberry S, Strobel M: Chikungunya, an epidemic arbovirosis. Lancet Infect Dis 2007, 7: 319–327. 10.1016/S1473-3099(07)70107-XPubMedCrossRef
6.
go back to reference Rishnamoorthy K, Harichandrakumar KT, Krishna Kumari A, Das LK: Burden of chikungunya in India: estimates of disability adjusted life years (DALY) lost in 2006 epidemic. J Vector Borne Dis 2009, 46: 26–35. Rishnamoorthy K, Harichandrakumar KT, Krishna Kumari A, Das LK: Burden of chikungunya in India: estimates of disability adjusted life years (DALY) lost in 2006 epidemic. J Vector Borne Dis 2009, 46: 26–35.
8.
go back to reference Robinson MC: An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53. I. Clinical features. Trans R Soc Trop med Hyg 1955, 49: 28–32. 10.1016/0035-9203(55)90080-8PubMedCrossRef Robinson MC: An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53. I. Clinical features. Trans R Soc Trop med Hyg 1955, 49: 28–32. 10.1016/0035-9203(55)90080-8PubMedCrossRef
9.
go back to reference Lumsden WH: An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53. II. General description and epidemiology. Trans R Soc Trop Med Hyg 1955, 49: 33–57. 10.1016/0035-9203(55)90081-XPubMedCrossRef Lumsden WH: An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53. II. General description and epidemiology. Trans R Soc Trop Med Hyg 1955, 49: 33–57. 10.1016/0035-9203(55)90081-XPubMedCrossRef
11.
go back to reference Muyembe-Tamfum JJ, Peyrefitte CN, Yogolelo R, Mathina Basisya E, Koyange D, Pukuta E, Mashako M, Tolou H, Durand JP: Epidemic of Chikungunya virus in 1999 and 2000 in the Democratic Republic of the Congo. Med Trop (Mars) 2003, 63: 637–638. Muyembe-Tamfum JJ, Peyrefitte CN, Yogolelo R, Mathina Basisya E, Koyange D, Pukuta E, Mashako M, Tolou H, Durand JP: Epidemic of Chikungunya virus in 1999 and 2000 in the Democratic Republic of the Congo. Med Trop (Mars) 2003, 63: 637–638.
12.
go back to reference World Health Organization: Guidelines for prevention and control of chikungunya fever. World Health Organization, Regional Office for South-East Asia, New Delhi; 2009. World Health Organization: Guidelines for prevention and control of chikungunya fever. World Health Organization, Regional Office for South-East Asia, New Delhi; 2009.
14.
go back to reference Centers for Disease Control and Prevention: Chikungunya fever diagnosed among international travelers—United States, 2005–2006. MMWR Morb Mortal Wkly Rep 2006, 55: 1040–1042. Centers for Disease Control and Prevention: Chikungunya fever diagnosed among international travelers—United States, 2005–2006. MMWR Morb Mortal Wkly Rep 2006, 55: 1040–1042.
15.
go back to reference Pistone T, Ezzedine K, Schuffenecker I, Receveur MC, Malvy D: An imported case of Chikungunya fever from Madagascar: use of the sentinel traveller for detecting emerging arboviral infections in tropical and European countries. Travel Med Infect Dis 2009, 7: 52–54. 10.1016/j.tmaid.2008.10.001PubMedCrossRef Pistone T, Ezzedine K, Schuffenecker I, Receveur MC, Malvy D: An imported case of Chikungunya fever from Madagascar: use of the sentinel traveller for detecting emerging arboviral infections in tropical and European countries. Travel Med Infect Dis 2009, 7: 52–54. 10.1016/j.tmaid.2008.10.001PubMedCrossRef
16.
go back to reference Yergolkar PN, Tandale BV, Arankalle VA, Sathe PS, Sudeep AB, Gandhe SS, Gokhle MD, Jacob GP, Hundekar SL, Mishra AC: Chikungunya outbreaks caused by African genotype, India. Emerg Infect Dis 2006, 12: 1580–1583. 10.3201/eid1210.060529PubMedCentralPubMedCrossRef Yergolkar PN, Tandale BV, Arankalle VA, Sathe PS, Sudeep AB, Gandhe SS, Gokhle MD, Jacob GP, Hundekar SL, Mishra AC: Chikungunya outbreaks caused by African genotype, India. Emerg Infect Dis 2006, 12: 1580–1583. 10.3201/eid1210.060529PubMedCentralPubMedCrossRef
17.
go back to reference Sam IC, Abu Bakar S: Chikungunya virus infection. Med J Malaysia 2006, 61: 264–269.PubMed Sam IC, Abu Bakar S: Chikungunya virus infection. Med J Malaysia 2006, 61: 264–269.PubMed
18.
go back to reference Robillard PY, Boumahni B, Gérardin P, Michault A, Fourmaintraux A, Schuffenecker I, Carbonnier M, Djémili S, Choker G, Roge-Wolter M, Barau G: Vertical maternal fetal transmission of the Chikungunya virus. Ten cases 84 among pregnant women. Presse Med 2006, 35: 785–788. 10.1016/S0755-4982(06)74690-5PubMedCrossRef Robillard PY, Boumahni B, Gérardin P, Michault A, Fourmaintraux A, Schuffenecker I, Carbonnier M, Djémili S, Choker G, Roge-Wolter M, Barau G: Vertical maternal fetal transmission of the Chikungunya virus. Ten cases 84 among pregnant women. Presse Med 2006, 35: 785–788. 10.1016/S0755-4982(06)74690-5PubMedCrossRef
19.
go back to reference Couderc T, Gangneux N, Chrétien F, Caro V, Le Luong T, Ducloux B, Tolou H, Lecuit M, Grandadam M: Chikungunya virus infection of corneal grafts. J Infect Dis 2012,206(6):851–9. 15 10.1093/infdis/jis296PubMedCrossRef Couderc T, Gangneux N, Chrétien F, Caro V, Le Luong T, Ducloux B, Tolou H, Lecuit M, Grandadam M: Chikungunya virus infection of corneal grafts. J Infect Dis 2012,206(6):851–9. 15 10.1093/infdis/jis296PubMedCrossRef
20.
go back to reference Paramasivan R, Philip Samuel P, Thenmozhi V, Rajendran R, Victor Jerald Leo S, Dhananjeyan KJ, Krishnamoorthi R, Arunachalam N, Tyagi BK: Chikungunya virus isolated in Lakshadweep islands in the Indian Ocean: evidence of the Central/East African genotype. Jpn J Infect Dis 2009, 62: 67–69.PubMed Paramasivan R, Philip Samuel P, Thenmozhi V, Rajendran R, Victor Jerald Leo S, Dhananjeyan KJ, Krishnamoorthi R, Arunachalam N, Tyagi BK: Chikungunya virus isolated in Lakshadweep islands in the Indian Ocean: evidence of the Central/East African genotype. Jpn J Infect Dis 2009, 62: 67–69.PubMed
21.
go back to reference Shah KV, Gibbs CJ Jr, Banerjee G: Virological investigation of the epidemic of haemorrhagic fever in Calcutta: isolation of three strains of Chikungunya virus. Indian J Med Res 1964, 52: 676–683.PubMed Shah KV, Gibbs CJ Jr, Banerjee G: Virological investigation of the epidemic of haemorrhagic fever in Calcutta: isolation of three strains of Chikungunya virus. Indian J Med Res 1964, 52: 676–683.PubMed
22.
go back to reference Schuffenecker I, Iteman I, Michault A, Murri S, Frangeul L, Vaney MC, Lavenir R, Pardigon N, Reynes JM, Pettinelli F, Biscornet L, Diancourt L, Michel S, Duquerroy S, Guigon G, Frenkiel MP, Bréhin AC, Cubito N, Desprès P, Kunst F, Rey FA, Zeller H, Brisse S: Genome microevolution of Chikungunya viruses causing the Indian Ocean outbreak. PLoS Med 2006, 3: e263. 10.1371/journal.pmed.0030263PubMedCentralPubMedCrossRef Schuffenecker I, Iteman I, Michault A, Murri S, Frangeul L, Vaney MC, Lavenir R, Pardigon N, Reynes JM, Pettinelli F, Biscornet L, Diancourt L, Michel S, Duquerroy S, Guigon G, Frenkiel MP, Bréhin AC, Cubito N, Desprès P, Kunst F, Rey FA, Zeller H, Brisse S: Genome microevolution of Chikungunya viruses causing the Indian Ocean outbreak. PLoS Med 2006, 3: e263. 10.1371/journal.pmed.0030263PubMedCentralPubMedCrossRef
23.
go back to reference Tsetsarkin KA, Vanlandingham DL, McGee CE, Higgs S: A single mutation in Chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog 2007, 3: e201. 10.1371/journal.ppat.0030201PubMedCentralPubMedCrossRef Tsetsarkin KA, Vanlandingham DL, McGee CE, Higgs S: A single mutation in Chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog 2007, 3: e201. 10.1371/journal.ppat.0030201PubMedCentralPubMedCrossRef
24.
go back to reference Samuel PP, Krishnamoorthi R, Hamzakoya KK, Aggarwal CS: Entomo-epidemiological investigations on chikungunya outbreak in the Lakshadweep islands, Indian Ocean. Indian J Med Res 2009, 129: 442–445.PubMed Samuel PP, Krishnamoorthi R, Hamzakoya KK, Aggarwal CS: Entomo-epidemiological investigations on chikungunya outbreak in the Lakshadweep islands, Indian Ocean. Indian J Med Res 2009, 129: 442–445.PubMed
25.
go back to reference Tang BL: The cell biology of Chikungunya virus infection. Cell Microbiol Sep 2012,14(9):1354–1363. 10.1111/j.1462-5822.2012.01825.xCrossRef Tang BL: The cell biology of Chikungunya virus infection. Cell Microbiol Sep 2012,14(9):1354–1363. 10.1111/j.1462-5822.2012.01825.xCrossRef
26.
go back to reference Wauquier N, Becquart P, Nkoghe D, Padilla C, Ndjoyi-Mbiguino A, Leroy EM: The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation. J Infect Dis 2011,204(1):115–123. 10.1093/infdis/jiq006PubMedCentralPubMedCrossRef Wauquier N, Becquart P, Nkoghe D, Padilla C, Ndjoyi-Mbiguino A, Leroy EM: The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation. J Infect Dis 2011,204(1):115–123. 10.1093/infdis/jiq006PubMedCentralPubMedCrossRef
27.
go back to reference Rulli NE, Suhrbier A, Hueston L, Heise MT, Tupanceska D, Zaid A, Wilmes A, Gilmore K, Lidbury BA, Mahalingam S: Ross River virus: molecular and cellular aspects of disease pathogenesis. Pharmacol Ther 2005, 107: 329–342. 10.1016/j.pharmthera.2005.03.006PubMedCrossRef Rulli NE, Suhrbier A, Hueston L, Heise MT, Tupanceska D, Zaid A, Wilmes A, Gilmore K, Lidbury BA, Mahalingam S: Ross River virus: molecular and cellular aspects of disease pathogenesis. Pharmacol Ther 2005, 107: 329–342. 10.1016/j.pharmthera.2005.03.006PubMedCrossRef
28.
go back to reference Jaffar-Bandjee MC, Gasque P: Physiopathology of chronic arthritis following chikungunya infection in man. Med Trop (Mars) 2012,72(Spec No):86–87. Jaffar-Bandjee MC, Gasque P: Physiopathology of chronic arthritis following chikungunya infection in man. Med Trop (Mars) 2012,72(Spec No):86–87.
29.
go back to reference Powers AM, Logue CH: Changing patterns of Chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol 2007, 88: 2363–2377. 10.1099/vir.0.82858-0PubMedCrossRef Powers AM, Logue CH: Changing patterns of Chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol 2007, 88: 2363–2377. 10.1099/vir.0.82858-0PubMedCrossRef
30.
go back to reference Mahendradas P: Chikungunya in uveitis: text & imaging. 1st edition. Jaypee Brothers, New Delhi; 2009:706–712. Mahendradas P: Chikungunya in uveitis: text & imaging. 1st edition. Jaypee Brothers, New Delhi; 2009:706–712.
31.
go back to reference Borgherini G, Poubeau P, Staikowsky F, Lory M, Le Moullec N, Becquart JP, Wengling C, Michault A, Paganin F: Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis 2007, 44: 1401–1407. 10.1086/517537PubMedCrossRef Borgherini G, Poubeau P, Staikowsky F, Lory M, Le Moullec N, Becquart JP, Wengling C, Michault A, Paganin F: Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis 2007, 44: 1401–1407. 10.1086/517537PubMedCrossRef
32.
go back to reference Ribéra A, Degasne I, Jaffar Bandjee MC, Gasque P: Chronic rheumatic manifestations following Chikungunya virus infection: clinical description and therapeutic considerations. Med Trop (Mars) 2012,72(Spec No):83–85. Ribéra A, Degasne I, Jaffar Bandjee MC, Gasque P: Chronic rheumatic manifestations following Chikungunya virus infection: clinical description and therapeutic considerations. Med Trop (Mars) 2012,72(Spec No):83–85.
33.
go back to reference Bandyopadhyay D, Ghosh SK: Mucocutaneous features of chikungunya fever: a study from an outbreak in West Bengal, India. Int J Dermatol 2008, 47: 1148–1152. 10.1111/j.1365-4632.2008.03817.xPubMedCrossRef Bandyopadhyay D, Ghosh SK: Mucocutaneous features of chikungunya fever: a study from an outbreak in West Bengal, India. Int J Dermatol 2008, 47: 1148–1152. 10.1111/j.1365-4632.2008.03817.xPubMedCrossRef
34.
go back to reference Inamadar AC, Palit A, Sampagavi VV, Raghunath S, Deshmukh NS: Cutaneous manifestations of chikungunya fever: observations made during a recent outbreak in south India. Int J Dermatol 2008, 47: 154–159. 10.1111/j.1365-4632.2008.03478.xPubMedCrossRef Inamadar AC, Palit A, Sampagavi VV, Raghunath S, Deshmukh NS: Cutaneous manifestations of chikungunya fever: observations made during a recent outbreak in south India. Int J Dermatol 2008, 47: 154–159. 10.1111/j.1365-4632.2008.03478.xPubMedCrossRef
35.
go back to reference Wadia RS: A neurotropic virus (Chikungunya) and a neuropathic aminoacid (homocysteine). Ann Indian Acad Neurol 2007, 10: 198–213. Wadia RS: A neurotropic virus (Chikungunya) and a neuropathic aminoacid (homocysteine). Ann Indian Acad Neurol 2007, 10: 198–213.
36.
go back to reference Rampal SM, Meena H: Neurological complications in chikungunya fever. J Assoc Physicians India 2007, 55: 765–769.PubMed Rampal SM, Meena H: Neurological complications in chikungunya fever. J Assoc Physicians India 2007, 55: 765–769.PubMed
37.
go back to reference Chandak NH, Kashyap RS, Kabra D, Karandikar P, Saha SS, Morey SH, Purohit HJ, Taori GM, Daginawala HF: Neurological complications of Chikungunya virus infection. Neurol India 2009, 57: 177–180. 10.4103/0028-3886.51289PubMedCrossRef Chandak NH, Kashyap RS, Kabra D, Karandikar P, Saha SS, Morey SH, Purohit HJ, Taori GM, Daginawala HF: Neurological complications of Chikungunya virus infection. Neurol India 2009, 57: 177–180. 10.4103/0028-3886.51289PubMedCrossRef
38.
go back to reference Singh SS, Manimunda SP, Sugunan AP, Sahina VP: Four cases of acute flaccid paralysis associated with Chikungunya virus infection. Epidemiol Infect 2008, 136: 1277–1280.PubMedCentralPubMed Singh SS, Manimunda SP, Sugunan AP, Sahina VP: Four cases of acute flaccid paralysis associated with Chikungunya virus infection. Epidemiol Infect 2008, 136: 1277–1280.PubMedCentralPubMed
39.
go back to reference Lee VJ, Chow A, Zheng X, Carrasco LR, Cook AR, Lye DC, Ng LC, Leo YS: Simple clinical and laboratory predictors of chikungunya versus dengue infections in adults. PLoS Negl Trop Dis 2012,6(9):e1786. 10.1371/journal.pntd.0001786PubMedCentralPubMedCrossRef Lee VJ, Chow A, Zheng X, Carrasco LR, Cook AR, Lye DC, Ng LC, Leo YS: Simple clinical and laboratory predictors of chikungunya versus dengue infections in adults. PLoS Negl Trop Dis 2012,6(9):e1786. 10.1371/journal.pntd.0001786PubMedCentralPubMedCrossRef
40.
go back to reference Oliver M, Grandadam M, Marimoutou C, Rogier C, Botelho-Nevers E, Tolou H, Moalic J-L, Kraemer P, Morillon M, Morand J-J, Jeandel P, Parola P, Simon F: Persisting mixed cryoglobulinemia in chikungunya infection. PLoS Negl Trop Dis 2009, 3: e374. 10.1371/journal.pntd.0000374PubMedCentralPubMedCrossRef Oliver M, Grandadam M, Marimoutou C, Rogier C, Botelho-Nevers E, Tolou H, Moalic J-L, Kraemer P, Morillon M, Morand J-J, Jeandel P, Parola P, Simon F: Persisting mixed cryoglobulinemia in chikungunya infection. PLoS Negl Trop Dis 2009, 3: e374. 10.1371/journal.pntd.0000374PubMedCentralPubMedCrossRef
41.
go back to reference Tandale BV, Sathe PS, Arankalle VA, Wadia RS, Kulkarni R, Shah SV, Shah SK, Sheth JK, Sudeep AB, Tripathy AS, Mishra AC: Systemic involvements and fatalities during chikungunya epidemic in India, 2006. J Clin Virol 2009, 46: 145–149. 10.1016/j.jcv.2009.06.027PubMedCrossRef Tandale BV, Sathe PS, Arankalle VA, Wadia RS, Kulkarni R, Shah SV, Shah SK, Sheth JK, Sudeep AB, Tripathy AS, Mishra AC: Systemic involvements and fatalities during chikungunya epidemic in India, 2006. J Clin Virol 2009, 46: 145–149. 10.1016/j.jcv.2009.06.027PubMedCrossRef
42.
go back to reference Bhavana K, Tyagi I, Kapila RK: Chikungunya virus induced sudden sensorineural hearing loss. Int J Pediatr Otorhinolaryngol 2008, 72: 257–259. 10.1016/j.ijporl.2007.09.022PubMedCrossRef Bhavana K, Tyagi I, Kapila RK: Chikungunya virus induced sudden sensorineural hearing loss. Int J Pediatr Otorhinolaryngol 2008, 72: 257–259. 10.1016/j.ijporl.2007.09.022PubMedCrossRef
43.
go back to reference Rampal SM, Meena H: Hypokalemic paralysis following chikungunya fever. J Assoc Physicians India 2007, 55: 598.PubMed Rampal SM, Meena H: Hypokalemic paralysis following chikungunya fever. J Assoc Physicians India 2007, 55: 598.PubMed
45.
go back to reference Mahendradas P, Ranganna SK, Shetty R, Balu R, Narayana KM, Babu RB, Shetty BK: Ocular manifestations associated with chikungunya. Ophthalmology 2008,115(2):287–291. 10.1016/j.ophtha.2007.03.085PubMedCrossRef Mahendradas P, Ranganna SK, Shetty R, Balu R, Narayana KM, Babu RB, Shetty BK: Ocular manifestations associated with chikungunya. Ophthalmology 2008,115(2):287–291. 10.1016/j.ophtha.2007.03.085PubMedCrossRef
46.
go back to reference Pellot AS, Alessandri JL, Robin S, Sampériz S, Attali T, Brayer C, Pasquet M, Jaffar-Bandjee MC, Benhamou LS, Tiran-Rajaofera I, Ramful D: Severe forms of Chikungunya virus infection in a pediatric intensive care unit on Reunion Island. Med Trop (Mars) 2012,72(Spec No):88–93. French Pellot AS, Alessandri JL, Robin S, Sampériz S, Attali T, Brayer C, Pasquet M, Jaffar-Bandjee MC, Benhamou LS, Tiran-Rajaofera I, Ramful D: Severe forms of Chikungunya virus infection in a pediatric intensive care unit on Reunion Island. Med Trop (Mars) 2012,72(Spec No):88–93. French
47.
go back to reference Markoff L, Togaviridae MGL, Bennet JE, Dolin R: Principles and practice of infectious disease. 5th edition. Churchill Livingstone, Philadelphia; 2000:1703–708. Markoff L, Togaviridae MGL, Bennet JE, Dolin R: Principles and practice of infectious disease. 5th edition. Churchill Livingstone, Philadelphia; 2000:1703–708.
48.
go back to reference Parola P, de Lamballerie X, Jourdan J, Rovery C, Vaillant V, Minodier P, Brouqui P, Flahault A, Raoult D, Charrel R: Novel Chikungunya virus variant in travelers returning from Indian Ocean islands. Emerg Infect Dis 2006, 12: 1493–1499. 10.3201/eid1210.060610PubMedCentralPubMedCrossRef Parola P, de Lamballerie X, Jourdan J, Rovery C, Vaillant V, Minodier P, Brouqui P, Flahault A, Raoult D, Charrel R: Novel Chikungunya virus variant in travelers returning from Indian Ocean islands. Emerg Infect Dis 2006, 12: 1493–1499. 10.3201/eid1210.060610PubMedCentralPubMedCrossRef
49.
go back to reference Lalitha P, Rathinam S, Banushree K, Maheshkumar S, Vijayakumar R, Sathe P: Ocular involvement associated with an epidemic outbreak of Chikungunya virus infection. Am J Ophthalmol 2008,144(4):552–556.CrossRef Lalitha P, Rathinam S, Banushree K, Maheshkumar S, Vijayakumar R, Sathe P: Ocular involvement associated with an epidemic outbreak of Chikungunya virus infection. Am J Ophthalmol 2008,144(4):552–556.CrossRef
50.
go back to reference Chanana B, Azad RV, Nair S: Bilateral macular choroiditis following Chikungunya virus infection. Eye (Lond) 2007,21(7):1020–1021. 10.1038/sj.eye.6702863CrossRef Chanana B, Azad RV, Nair S: Bilateral macular choroiditis following Chikungunya virus infection. Eye (Lond) 2007,21(7):1020–1021. 10.1038/sj.eye.6702863CrossRef
51.
go back to reference Mahesh G, Giridhar A, Shedbele A, Kumar R, Saikumar SJ: A case of bilateral presumed chikungunya neuroretinitis. Indian J Ophthalmol 2009,57(2):148–150. 10.4103/0301-4738.45508PubMedCrossRef Mahesh G, Giridhar A, Shedbele A, Kumar R, Saikumar SJ: A case of bilateral presumed chikungunya neuroretinitis. Indian J Ophthalmol 2009,57(2):148–150. 10.4103/0301-4738.45508PubMedCrossRef
52.
53.
go back to reference Mittal A, Mittal S, Bharati MJ, Ramakrishnan R, Saravanan S, Sathe PS: Optic neuritis associated with Chikungunya virus infection in South India. Arch Ophthalmol 2007,125(10):1381–1386. 10.1001/archopht.125.10.1381PubMedCrossRef Mittal A, Mittal S, Bharati MJ, Ramakrishnan R, Saravanan S, Sathe PS: Optic neuritis associated with Chikungunya virus infection in South India. Arch Ophthalmol 2007,125(10):1381–1386. 10.1001/archopht.125.10.1381PubMedCrossRef
54.
go back to reference Rose N, Anoop TM, John AP, Jabbar PK, George KC: Acute optic neuritis following infection with Chikungunya virus in southern rural India. Int J Infect Dis 2011,15(2):e147-e150. 10.1016/j.ijid.2010.10.004PubMedCrossRef Rose N, Anoop TM, John AP, Jabbar PK, George KC: Acute optic neuritis following infection with Chikungunya virus in southern rural India. Int J Infect Dis 2011,15(2):e147-e150. 10.1016/j.ijid.2010.10.004PubMedCrossRef
55.
go back to reference Chan CK, Limstrom SA, Tarasewicz DG, Lin SG: Ocular features of West Nile virus infection in North America: a study of 14 eyes. Ophthalmology 2006,113(9):1539–1546. 10.1016/j.ophtha.2006.04.021PubMedCrossRef Chan CK, Limstrom SA, Tarasewicz DG, Lin SG: Ocular features of West Nile virus infection in North America: a study of 14 eyes. Ophthalmology 2006,113(9):1539–1546. 10.1016/j.ophtha.2006.04.021PubMedCrossRef
56.
go back to reference Shukla J, Saxena D, Rathinam S, Lalitha P, Joseph CR, Sharma S, Soni M, Rao PV, Parida M: Molecular detection and characterization of West Nile virus associated with multifocal retinitis in patients from southern India. Int J Infect Dis 2012,16(1):e53-e59. 10.1016/j.ijid.2011.09.020PubMedCrossRef Shukla J, Saxena D, Rathinam S, Lalitha P, Joseph CR, Sharma S, Soni M, Rao PV, Parida M: Molecular detection and characterization of West Nile virus associated with multifocal retinitis in patients from southern India. Int J Infect Dis 2012,16(1):e53-e59. 10.1016/j.ijid.2011.09.020PubMedCrossRef
57.
go back to reference Mahalingam S, Meanger J, Foster PS, Lidbury BA: The viral manipulation of the host cellular and immune environments to enhance propagation and survival: a focus on RNA viruses. J Leukoc Biol 2002, 72: 429–439.PubMed Mahalingam S, Meanger J, Foster PS, Lidbury BA: The viral manipulation of the host cellular and immune environments to enhance propagation and survival: a focus on RNA viruses. J Leukoc Biol 2002, 72: 429–439.PubMed
58.
go back to reference Pfeffer M, Linssen B, Parke MD, Kinney RM: Specific detection of Chikungunya virus using a RT-PCR/nested PCR combination. J Vet Med B Infect Dis Vet Public Health 2002, 49: 49–54. 10.1046/j.1439-0450.2002.00535.xPubMedCrossRef Pfeffer M, Linssen B, Parke MD, Kinney RM: Specific detection of Chikungunya virus using a RT-PCR/nested PCR combination. J Vet Med B Infect Dis Vet Public Health 2002, 49: 49–54. 10.1046/j.1439-0450.2002.00535.xPubMedCrossRef
59.
go back to reference Hasebe F, Parquet MC, Pandey BD, Mathenge EG, Morita K, Balasubramaniam V, Saat Z, Yusop A, Sinniah M, Natkunam S, Igarashi A: Combined detection and genotyping of Chikungunya virus by a specific reverse transcription polymerase chain reaction. J Med Virol 2002, 67: 370–374. 10.1002/jmv.10085PubMedCrossRef Hasebe F, Parquet MC, Pandey BD, Mathenge EG, Morita K, Balasubramaniam V, Saat Z, Yusop A, Sinniah M, Natkunam S, Igarashi A: Combined detection and genotyping of Chikungunya virus by a specific reverse transcription polymerase chain reaction. J Med Virol 2002, 67: 370–374. 10.1002/jmv.10085PubMedCrossRef
60.
go back to reference Pastorino B, Bessaud M, Grandadam M, Murri S, Tolou HJ, Peyrefitte CN: Development of a TaqMan RT-PCR assay without RNA extraction step for the detection and quantification of African Chikungunya viruses. J Virol Methods 2005, 124: 65–71. 10.1016/j.jviromet.2004.11.002PubMedCrossRef Pastorino B, Bessaud M, Grandadam M, Murri S, Tolou HJ, Peyrefitte CN: Development of a TaqMan RT-PCR assay without RNA extraction step for the detection and quantification of African Chikungunya viruses. J Virol Methods 2005, 124: 65–71. 10.1016/j.jviromet.2004.11.002PubMedCrossRef
61.
go back to reference Lakshmi V, Neeraja M, Subbalaxmi MV, Parida MM, Dash PK, Santhosh SR, Rao PV: Clinical features and molecular diagnosis of chikungunya fever from South India. Clin Infect Dis 2005, 46: 1436–1442.CrossRef Lakshmi V, Neeraja M, Subbalaxmi MV, Parida MM, Dash PK, Santhosh SR, Rao PV: Clinical features and molecular diagnosis of chikungunya fever from South India. Clin Infect Dis 2005, 46: 1436–1442.CrossRef
62.
go back to reference Grivard P, Le Roux K, Laurent P, Fianu A, Perrau J, Gigan J, Hoarau G, Grondin N, Staikowsky F, Favier F, Michault A: Molecular and serological diagnosis of Chikungunya virus infection. Pathol Biol (Paris) 2007, 55: 490–494. 10.1016/j.patbio.2007.07.002CrossRef Grivard P, Le Roux K, Laurent P, Fianu A, Perrau J, Gigan J, Hoarau G, Grondin N, Staikowsky F, Favier F, Michault A: Molecular and serological diagnosis of Chikungunya virus infection. Pathol Biol (Paris) 2007, 55: 490–494. 10.1016/j.patbio.2007.07.002CrossRef
63.
go back to reference Blacksell SD, Tanganuchitcharnchai A, Jarman RG, Gibbons RV, Paris DH, Bailey MS, Day NP, Premaratna R, Lalloo DG, de Silva HJ: Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute chikungunya infection. Clin Vaccine Immunol 2011,18(10):1773–1775. 10.1128/CVI.05288-11PubMedCentralPubMedCrossRef Blacksell SD, Tanganuchitcharnchai A, Jarman RG, Gibbons RV, Paris DH, Bailey MS, Day NP, Premaratna R, Lalloo DG, de Silva HJ: Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute chikungunya infection. Clin Vaccine Immunol 2011,18(10):1773–1775. 10.1128/CVI.05288-11PubMedCentralPubMedCrossRef
64.
go back to reference Mahendradas P, Shetty R, Malathi J, Madhavan HN: Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. Indian J Ophthalmol 2010,58(6):545–547. 10.4103/0301-4738.71707PubMedCentralPubMedCrossRef Mahendradas P, Shetty R, Malathi J, Madhavan HN: Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. Indian J Ophthalmol 2010,58(6):545–547. 10.4103/0301-4738.71707PubMedCentralPubMedCrossRef
65.
go back to reference Babu K, Murthy GJ: Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. Indian J Ophthalmol 2012,60(1):73–74. 10.4103/0301-4738.90495PubMedCentralPubMedCrossRef Babu K, Murthy GJ: Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. Indian J Ophthalmol 2012,60(1):73–74. 10.4103/0301-4738.90495PubMedCentralPubMedCrossRef
66.
go back to reference Parida MM: Rapid and real-time detection technologies for emerging viruses of biomedical importance. J Biosci 2008, 33: 617–628. 10.1007/s12038-008-0079-7PubMedCrossRef Parida MM: Rapid and real-time detection technologies for emerging viruses of biomedical importance. J Biosci 2008, 33: 617–628. 10.1007/s12038-008-0079-7PubMedCrossRef
67.
go back to reference Parida MM, Santhosh SR, Dash PK, Tripathi NK, Lakshmi V, Mamidi N, Shrivastva A, Gupta N, Saxena P, Babu JP, Rao PV, Morita K: Rapid and real-time detection of Chikungunya virus by reverse transcription loop-mediated isothermal amplification assay. J Clin Microbiol 2007, 45: 351–357. 10.1128/JCM.01734-06PubMedCentralPubMedCrossRef Parida MM, Santhosh SR, Dash PK, Tripathi NK, Lakshmi V, Mamidi N, Shrivastva A, Gupta N, Saxena P, Babu JP, Rao PV, Morita K: Rapid and real-time detection of Chikungunya virus by reverse transcription loop-mediated isothermal amplification assay. J Clin Microbiol 2007, 45: 351–357. 10.1128/JCM.01734-06PubMedCentralPubMedCrossRef
68.
go back to reference Smith DR, Lee JS, Jahrling J, Kulesh DA, Turell MJ, Groebner JL, O'Guinn ML: Development of field-based real-time reverse transcription-polymerase chain reaction assays for detection of Chikungunya and O'nyong-nyong viruses in mosquitoes. Am J Trop Med Hyg 2009, 81: 679–684. 10.4269/ajtmh.2009.09-0138PubMedCrossRef Smith DR, Lee JS, Jahrling J, Kulesh DA, Turell MJ, Groebner JL, O'Guinn ML: Development of field-based real-time reverse transcription-polymerase chain reaction assays for detection of Chikungunya and O'nyong-nyong viruses in mosquitoes. Am J Trop Med Hyg 2009, 81: 679–684. 10.4269/ajtmh.2009.09-0138PubMedCrossRef
69.
go back to reference Shukla J, Khan M, Tiwari M, Sannarangaiah S, Sharma S, Rao PV, Parida M: Development and evaluation of antigen capture ELISA for early clinical diagnosis of chikungunya. Diagn Microbiol Infect Dis 2009, 65: 142–149. 10.1016/j.diagmicrobio.2009.06.017PubMedCrossRef Shukla J, Khan M, Tiwari M, Sannarangaiah S, Sharma S, Rao PV, Parida M: Development and evaluation of antigen capture ELISA for early clinical diagnosis of chikungunya. Diagn Microbiol Infect Dis 2009, 65: 142–149. 10.1016/j.diagmicrobio.2009.06.017PubMedCrossRef
70.
go back to reference Lamballerie X, Boisson V, Reynier JC, Enault S, Charrel RN, Flahault A, Roques P, Le Grand R: On chikungunya acute infection and chloroquine treatment. Vector Borne Zoonotic Dis 2008, 8: 837–839. 10.1089/vbz.2008.0049PubMedCrossRef Lamballerie X, Boisson V, Reynier JC, Enault S, Charrel RN, Flahault A, Roques P, Le Grand R: On chikungunya acute infection and chloroquine treatment. Vector Borne Zoonotic Dis 2008, 8: 837–839. 10.1089/vbz.2008.0049PubMedCrossRef
71.
go back to reference Brighton SW: Chloroquine phosphate treatment of chronic chikungunya arthritis. An open pilot study. S Afr Med J 1984, 66: 217–218.PubMed Brighton SW: Chloroquine phosphate treatment of chronic chikungunya arthritis. An open pilot study. S Afr Med J 1984, 66: 217–218.PubMed
72.
go back to reference Bouquillard E, Combe B: A report of 21 cases of rheumatoid arthritis following chikungunya fever. A mean follow-up of 2 years. Joint Bone Spine 2009, 76: 654–657. 10.1016/j.jbspin.2009.08.005PubMedCrossRef Bouquillard E, Combe B: A report of 21 cases of rheumatoid arthritis following chikungunya fever. A mean follow-up of 2 years. Joint Bone Spine 2009, 76: 654–657. 10.1016/j.jbspin.2009.08.005PubMedCrossRef
73.
go back to reference Murthy KR, Venkataraman N, Satish V, Babu K: Bilateral retinitis following chikungunya fever. Indian J Ophthalmol 2008,56(4):329–331. 10.4103/0301-4738.41419PubMedCentralPubMedCrossRef Murthy KR, Venkataraman N, Satish V, Babu K: Bilateral retinitis following chikungunya fever. Indian J Ophthalmol 2008,56(4):329–331. 10.4103/0301-4738.41419PubMedCentralPubMedCrossRef
74.
go back to reference Chhabra M, Mittal V, Bhattacharya D, Rana U, Lal S: Chikungunya fever: a re-emerging viral infection. Indian J Med Microbiol 2008,26(1):5–12. 10.4103/0255-0857.38850PubMedCrossRef Chhabra M, Mittal V, Bhattacharya D, Rana U, Lal S: Chikungunya fever: a re-emerging viral infection. Indian J Med Microbiol 2008,26(1):5–12. 10.4103/0255-0857.38850PubMedCrossRef
75.
go back to reference Couderc T, Khandoudi N, Grandadam M, Visse C, Gangneux N, Bagot S, Prost JF, Lecuit M: Prophylaxis and therapy for Chikungunya virus infection. J Infect Dis 2008, 200: 516–523.CrossRef Couderc T, Khandoudi N, Grandadam M, Visse C, Gangneux N, Bagot S, Prost JF, Lecuit M: Prophylaxis and therapy for Chikungunya virus infection. J Infect Dis 2008, 200: 516–523.CrossRef
76.
go back to reference Simon F, Javelle E, Oliver M, Leparc-Goffart I, Marimoutou C: Chikungunya virus infection. Curr Infect Dis Rep 2011,13(3):218–228. 10.1007/s11908-011-0180-1PubMedCentralPubMedCrossRef Simon F, Javelle E, Oliver M, Leparc-Goffart I, Marimoutou C: Chikungunya virus infection. Curr Infect Dis Rep 2011,13(3):218–228. 10.1007/s11908-011-0180-1PubMedCentralPubMedCrossRef
77.
go back to reference Muthumani K, Lankaraman KM, Laddy DJ, Sundaram SG, Chung CW, Sako E, Wu L, Khan A, Sardesai N, Kim JJ, Vijayachari P, Weiner DB: Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus. Vaccine 2008, 26: 5128–5134. 10.1016/j.vaccine.2008.03.060PubMedCentralPubMedCrossRef Muthumani K, Lankaraman KM, Laddy DJ, Sundaram SG, Chung CW, Sako E, Wu L, Khan A, Sardesai N, Kim JJ, Vijayachari P, Weiner DB: Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus. Vaccine 2008, 26: 5128–5134. 10.1016/j.vaccine.2008.03.060PubMedCentralPubMedCrossRef
Metadata
Title
Chikungunya and the eye: a review
Authors
Padmamalini Mahendradas
Kavitha Avadhani
Rohit Shetty
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
Journal of Ophthalmic Inflammation and Infection / Issue 1/2013
Electronic ISSN: 1869-5760
DOI
https://doi.org/10.1186/1869-5760-3-35

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