Top

Published in:

01-06-2015 | Chest

Chest HRCT findings in acute transformation of adult T-cell lymphoma/leukemia

Authors: Fumito Okada, Haruka Sato, Ahmad Khalid Omeri, Asami Ono, Kouhei Tokuyama, Yumiko Ando, Akira Matsumoto, Masao Ogata, Kazuhiro Kohno, Kuniko Takano, Hiromu Mori

Published in: European Radiology | Issue 6/2015

Abstract

Objectives

To assess chest high-resolution computed tomography (HRCT) findings in patients with acute transformation of adult T cell leukaemia/lymphoma (ATLL).

Methods

We retrospectively identified 72 consecutive patients at our institution with ATLL between October 2000 and March 2014. The cases included acute type (n = 20), lymphoma type (n = 21), smouldering type (n = 24) and chronic type (n = 7). Sixteen (7 men, 9 women; aged 36–85 years, mean 63.3 years) of 31 patients (24 with smouldering and seven with chronic type; 51.6 %) developed acute transformation of ATLL, and had undergone chest HRCT examinations. Parenchymal abnormalities, enlarged lymph nodes, pericardial effusion, pleural effusion and skin lesions were evaluated on HRCT.

Results

Chest HRCT of 15 of the 16 patients showed abnormal findings, including ground-glass opacity (GGO) (n = 8), consolidation (n = 5), interlobular septal thickening (n = 5) and nodules (n = 5). Pleural effusion was found in five patients, lymph node enlargement in 10 patients and multiple skin thickening in two patients.

Conclusions

Almost all patients with acute transformation of ATLL had abnormal findings on chest HRCT, which consisted mainly of lymph node enlargement, GGO, interlobular septal thickening, nodules and bilateral pleural effusions.

Key points

• The recognition of CT findings of acute transformation is important

• Almost all patients with acute transformation have abnormal findings on HRCT

• Characteristic CT features are present in acute transformation of indolent ATLL

Gibbs WN, Lofters WS, Campbell M et al (1987) Non-Hodgkin lymphoma in Jamaica and its relation to adult T-cell leukemia-lymphoma. Ann Intern Med 106:361–368CrossRefPubMed

Takasaki Y, Iwanaga M, Imaizumi Y et al (2010) Long-term study of indolent adult T-cell leukemia-lymphoma. Blood 115:4337–4343CrossRefPubMed

Okada F, Ando Y, Kondo Y, Matsumoto S, Maeda T, Mori H (2004) Thoracic CT findings of adult T-cell leukemia or lymphoma. Am J Roentgenol 182:761–767CrossRef

Hanaka M, Yatera K, Itoh C et al (2013) Case of adult T-cell leukemia/lymphoma with rapid progression of pulmonary areas of ground-glass attenuation and multiple nodules. Respir Investig 51:41–45

Hansell DM, Bankier AA, MacMahon H, McLoud TC, Muller NL, Remy J (2008) Fleischner Society: glossary of terms for thoracic imaging. Radiology 246:697–722CrossRefPubMed

Uchiyama T, Todoi J, Sagawa K, Takatsuki K, Uchio H (1977) Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 50:481–492PubMed

Weber J (1990) HTLV-1 infection in Britain. Br Med J 301:71–72CrossRef

Dixon AC, Dixon PS, Nakamura JM (1989) Infection with the human T-lymphotropic virus type 1: a review for clinicians. Wes J Med 151:632–637

[No authors listed] (1988) HTLV-1 comes of age. Lancet 1(8579):217–219

10.

Shimoyama M (1991) Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma: a report from the Lymphoma Study Group (1984-87). Br J Haematol 79:428–437CrossRefPubMed

11.

Ishitsuka K, Ikeda S, Utsunomiya A et al (2008) Smouldering adult T-cell leukaemia/lymphoma: a follow-up study in Kyushu. Br J Haematol 143:442–444CrossRefPubMed

12.

Tsukasaki K, Tanosaki S, DeVos S et al (2004) Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide micoroarrays. Int J Cancer 109:875–881CrossRefPubMed

13.

Nakada K, Kohakura M, Komoda H, Hinuma Y (1984) High incidence of HTLV-1 antibody in carriers of Strongyloides stercoralis. Lancet 17:633CrossRef

14.

Sato Y, Shiroma Y (1989) Concurrent infections with Strongyloides and T-cell leukemia virus and their possible effect on immune responses of host. Clin Immunol Immnopathol 52:214–224CrossRef

15.

Sato Y, Toma H, Takara M, Kiyuna S, Shiroyama Y (1990) Seroepidemiological studies in the concomitance of strongyloidiasis with T-cell leukemia viral infection in Okinawa, Japan. Jpn J Parasitol 39:376–383

16.

Stewart DM, Ramanathan R, Mahanty S, Fedorko DP, Janik JE, Morris JC (2011) Dissseminated Strongyloides stercoralis infection in HTV-1-associated adult T-cell leukemia/lymphoma. Acta Haematol 126:63–67CrossRefPubMedCentralPubMed

17.

Nakada K, Yamaguchi K, Furugen S et al (1987) Monoclonal integration of HTLV-1 proviral DNA in patients with strongyloidiasis. Int J Cancer 40:145–148CrossRefPubMed

18.

D’Incan M, Combemale P, Verrier B et al (1994) Transient adult T-cell leukemina/lymphoma picture during varicella infection in an HTLV-1 carrier. Leukemia 8:682–687PubMed

19.

Okada F, Ando Y, Wakisaka M, Matsumoto S, Mori H (2005) Chlamydia pneumoniae pneumonia and Mycoplasma pneumoniae pneumonia: comparison of clinical findings and CT findings. J Comput Assist Tomogr 29:626–632CrossRefPubMed

20.

Okada F, Ando Y, Tanoue S et al (2012) Radiological findings in acute Haemophilus influenzae pulmonary infection. Br J Radiol 85:121–126CrossRefPubMedCentralPubMed

21.

Okada F, Ando Y, Nakayama T et al (2011) Pulmonary thin-section CT findings in acute Moraxella catarrhalis pulmonary infection. Br J Radiol 84:1109–1114CrossRefPubMedCentralPubMed

22.

Morikawa K, Okada F, Ando Y et al (2012) Methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus pneumonia: comparison of clinical and thin-section CT findings. Br J Radiol 85:e168–e175CrossRefPubMedCentralPubMed

23.

Okada F, Ando Y, Matsushita S et al (2012) Thin-section computed tomography findings of patients with acute Streptococcus pneumoniae pneumonia with and without concurrent infection. Br J Radiol 85:e357–e364CrossRefPubMedCentralPubMed

24.

Okada F, Ando Y, Honda K et al (2009) Clinical and pulmonary thin-section CT findings in acute Klebsiella pneumoniae pneumonia. Eur Radiol 19:809–815CrossRefPubMed

25.

Okada F, Ando Y, Honda K et al (2010) Acute Klebsiella pneumoniae pneumonia alone and with concurrent infection: comparison of clinical and thin-section CT findings. Br J Radiol 83:854–860CrossRefPubMedCentralPubMed

26.

Okada F, Ono A, Ando Y et al (2013) High-resolution CT findings in Streptococcus milleri pulmonary infection. Clin Radiol 68:e331–e337CrossRefPubMed

27.

Ono A, Okada F, Takata S et al (2014) A comparative study of thin-section CT findings between seasonal influenza virus pneumonia and Streptococcus pneumoniae pneumonia. Br J Radiol. doi:10.1259/bjr.20140051 PubMed

28.

Franquet T (2011) Imaging of pulmonary viral pneumonia. Radiology 260:18–39CrossRefPubMed

29.

Gasparetto EL, Ono SE, Escuissato D, Marchiori E, Roldan L, Marques HL (2004) Cytomegalovirus pneumonia after bone marrow transplantation: high resolution CT findings. Br J Radiol 77:724–727CrossRefPubMed

30.

Kuhlman JE, Kavuru M, Fishman EK, Siegelman SS (1990) Pneumocystis carinii pneumonia: spectrum of parenchymal CT findings. Radiology 175:711–714CrossRefPubMed

Title: Chest HRCT findings in acute transformation of adult T-cell lymphoma/leukemia
Authors: Fumito Okada
Haruka Sato
Ahmad Khalid Omeri
Asami Ono
Kouhei Tokuyama
Yumiko Ando
Akira Matsumoto
Masao Ogata
Kazuhiro Kohno
Kuniko Takano
Hiromu Mori
Publication date: 01-06-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 6/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3565-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Chest HRCT findings in acute transformation of adult T-cell lymphoma/leukemia

Abstract

Objectives

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

Please log in to get access to this content

Other articles of this Issue 6/2015

Value of CT findings to predict surgical ischemia in small bowel obstruction: A systematic review and meta-analysis

Intravoxel incoherent motion diffusion-weighted imaging in the liver: comparison of mono-, bi- and tri-exponential modelling at 3.0-T

Arterial and portal venous liver perfusion using selective spin labelling MRI

Diagnostic performance of direct traction MR arthrography of the hip: detection of chondral and labral lesions with arthroscopic comparison

Image quality of low mA CT pulmonary angiography reconstructed with model based iterative reconstruction versus standard CT pulmonary angiography reconstructed with filtered back projection: an equivalency trial

Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value?