Published in:
Open Access
01-08-2015 | Pictorial Review
Chemotherapy-related complications in the kidneys and collecting system: an imaging perspective
Authors:
Jemianne Bautista Jia, Chandana Lall, Temel Tirkes, Rajesh Gulati, Ramit Lamba, Scott C. Goodwin
Published in:
Insights into Imaging
|
Issue 4/2015
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Abstract
Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin. Certain chemotherapeutic agents have adverse effects on the kidneys and urothelium that can be visualized radiographically, including cystic change, interstitial nephritis, papillary necrosis, urothelial changes, haemorrhagic cystitis, acute tubular necrosis, and infarction. This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians.
Teaching Points
• Nephrotoxicity is a common adverse effect of many chemotherapeutic agents.
• Chemotherapies have adverse renal and urothelial effects that can be visualized radiographically.
• Crizotinib use can result in the development of complex renal cysts.